Nasopharyngeal carcinoma in Ibadan, Nigeria: a clinicopathologic study (original) (raw)
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Journal of Medicine and Biomedical Research, 2015
Studies have it that squamous cell carcinoma (SCC) of the head and neck has contributed hugely to the burden of cancer globally. In the United States of America head and neck SCC constituted vast majority (5-8%) of all cancer diagnosis. The objective of this study is to make a broad description of Head and neck cancer (HNC) frequency and Histological patterns in Benin-City, Nigeria and to compare these findings with other similar research works elsewhere. A review of histopathology diagnosis of all SCC of the HNC encountered at University of Benin Teaching Hospital (UBTH) between January 2008 and December 2012. All specimens were fixed in 10% formalin solution, processed with Histokinette automated tissue processor, paraffin embedded, and sectioned at 3-5 microns with microtome machine before staining with haematoxylin and eosin. The Histopathological diagnoses were analyzed with respect to age, sex, anatomical sites and histological patterns. A total of 216 cases constituting 83.4%...
International Journal of Otorhinolaryngology and Head and Neck Surgery
Background: Nasopharyngeal carcinoma (NPC) is an uncommon malignant tumor which has been reported invariably and cases have been encountered in Tanzania. Though rare they are associated with potential morbidity and mortality. The aim of this study was to characterize the clinico-pathological profile of such neoplasm in our set up.Methods: A retrospective review of 25 cases from hospital archives for 3 consecutive years was done where all patients with a histopathologically confirmed diagnosis of NPC were recruited. Data was analyzed using SPSS version 21.Results: Of the 25 eligible cases, 15 (60%) were males and 10 (40%) were females. Age range was 15-70 years. The peak age was 30-50 years in males and 50-59 years in females. Highest incidence was in the 5th decade. The commonest presenting features were cervical lymphadenopathy (92%) epistaxis (80%), hearing loss (80%) and nasal obstruction (76%) while the least common feature was seizures (4%). Histologically, undifferentiated car...
Nasopharyngeal Carcinoma Profile in dr. Cipto Mangunkusumo Hospital Year 2013
Radioterapi & Onkologi Indonesia
Background: Nasophar yngeal car cinoma (NPC) r emains as a health bur den in Indonesia. It is one of most common cancers in Indonesia, with an overall incidence estimated at 6.2/100,000 or 12,000 new cases per year. Unfortunately, many of these cases are unregistered due to several factors, such as lack of national cancer registry. In most developing countries, cancer registration often begins in hospitals. Hospital-Based Cancer Registry (HBCR) provides the initial and major source of information on patients that leads to the setup of a population-based registry. Materials and Methods: This was a descr iptive r etr ospective study of all r egistered NPC patient in HBCR, from January-December 2013. All registered NPC patients in HBCR in the year 2013 is included. Results: Ther e wer e 299 NPC patients, with a male-to-female ratio of 2.4:1. Median age was 47 years old, with majority of age between 40-49 years old (27.4%). Most common type of histology was undifferentiated NPC (85%). Most patients presented with locally advanced disease, with majority of stage IVA (33.9%). Chemoradiation remained as standard treatment for locally advanced NPC (84.1%). Conclusion: Demogr aphic data of patients, such as age and sex, ar e consistent with previous studies. Whereas racial distribution was not parallel with previous studies, maybe due to its lack of available data. Moreover, most common histopathology type and presentation was undifferentiated NPC and patients with Stage III to IV cancer.
International forum of allergy & rhinology, 2014
Nasopharyngeal squamous cell carcinoma (NPSCC) is uncommon in non-endemic regions. Two major histologic subtypes are recognized: keratinizing (K-NPSCC) and nonkeratinizing (NK-NPSCC). We hypothesize that significant differences exist between the 2 in terms of demographic, clinicopathologic, survival, and prognostic features. We aim to show that differentiating between the 2 subtypes is perhaps the most important first step at the time of diagnosis. Using a retrospective cohort design, the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was used to extract data on the 2 major subtypes of NPSCC. Frequency, incidence, and relative survival (RS) were analyzed comparatively. Regression analysis was conducted and hazard ratios (HRs) calculated. A total of 1624 cases were identified: 1234 (76.0%) cases of NK-NPSCC and 390 (24.0%) cases of K-NPSCC. Five-year RS was 60.6% for NK-NPSCC and 40.5% for K-NPSCC. Regression analysis revealed K-NPSCC...
Pattern of head and neck cancer in a tertiary institution in Lagos, Nigeria
Journal of Clinical Oncology, 2015
Cancer of the head and neck cancer in Nigeria with a population of over 167 million is a major health problem because of its high incidence and the limited infrastructure necessary for treatment. This study aims to examine the presentation and management of this disease in Nigeria. This is a retrospective study among head and neck cancer patients with histology of Lagos University Teaching Hospital in Nigeria. A total of 162 cases were analysed, which revealed about 23 cases annually, prevalence rate of 6.74% and a mean age of 49.50±19.73years. The peak age range was 4 th-5 th decade (40.2%). There were 102(63%) male and 60(37%) female with a M:F of 1.7:1. The commonest histological type was squamous cell carcinoma (75.2%). The commonest site was the nasopharynx 22(13.6%). Only 67 cases had stage of disease recorded, 54(80.6%) were stages III & IV. Survival outcome revealed that 23(14.2%) died, 16(9.9%) were still on followup and 123(75.9%) were lost to follow-up. Conclusion: Increased populace awareness programs emphasizing the preventable factors associated with this cancer and change in life style will decrease morbidity and mortality associated with late stage presentation.
Clinicopathological study of head and neck cancers in Ilorin, Nigeria
Tropical doctor, 2005
Eighty-nine cases of head and neck cancers were studied over a 5-year period (1997)(1998)(1999)(2000)(2001) at the University of IlorinTeaching Hospital, Nigeria.The most common cancer affecting the head and neck region was carcinoma which constituted 70.8% of all th<ecases studied. It was followed by the lymphomas and blastomas which accounted for 20.2% and 9%, respectively. The nose/paranasal sinuses were the most common site of primary cancer (18%)followed by thyroid (12.4%),nasopharynx (11.3%)and larynx (4.5%).Other sites include a hypopharynx (3.4%),eye (2.2%), palate (2.2%),tongue (2.2%), skin (1.1%), lip (1.1%), salivary gland (1.1%), oropharynx (1.1%). Cervical lymph node metastasis with unknown primarylesionwas seen in10.1%. Thepeak age incidence was in the fifth decade of life.The improvement in locoregional control of head and neck cancers over the last decades does not appear to modify the final survival of these patients. It iscrucial to understand as accurately as possible the risk factors for these malignancies in order to improve primary prevention.
Head & Face Medicine, 2011
Introduction This retrospective study analysed head and neck malignancies seen over a 19-year period at the University College Hospital, Ibadan. Methodology One thousand, one hundred and ninety two patients with head and neck malignancies were analysed according to age, gender, topography and histology. Results There was an annual hospital frequency of 62 cases per year. The overall mean age for these malignancies was 43.9 (SD ± 19.3) years. The lesions from the respiratory tract were the most frequent (43.2%) of all cases. The palate was the most frequent intra-oral site (13.8%). Epithelial malignancies constituted 73.4% of all cases with a male: female ratio of 2:1, a mean age of 48.1 (SD ± 17.5) years and were mostly located in the larynx (19.7%). Lymphomas constituted 17.5% of all head and neck cancers with a male: female ratio of 1.6:1, a mean age of 35.1 (SD ± 20.6) years and nodal involvement (39.7%) was most common. Sarcomas constituted 8.9% of all malignancies with a male: female ratio of 1.5:1, mean age of 27.1 (SD ± 16.7) years and the maxillofacial bones (42.5%) were most commonly involved. Neuroendocrine malignancies accounted for 0.2% of head and neck malignancies with a male: female ratio of 1:1, a mean age of 28.5 (SD ± 6.4) years and both cases involved the nose. Conclusion This study has further confirmed that carcinomas remain the most frequent cancers of the head and neck region in south-western Nigeria.
A Six-Year Review of Head and Neck Cancers at the Komfo Anokye Teaching Hospital, Kumasi, Ghana
International Journal of Otolaryngology and Head & Neck Surgery, 2014
Background: In Ghana, information on the prevalence and pattern of Head and Neck Cancers (HNCA) is scarce. There are few publications based on specific sub-sites of the head and neck, however, literature on the prevalence and pattern of HNCA in general is lacking. The present study aimed to describe the pattern of HNCA among patients seen at the multidisciplinary HNCA clinic of Komfo Anokye Teaching Hospital. Methods: This is a retrospective review of all consecutive patient records seen at the multidisciplinary clinic from 2004 to 2009. Results: There were 149 males and 103 females giving a male to female ratio of 1.45:1. The age range was 2 -95 years with a mean of 48.1 years. The commonest type of HNCA in this review is cancers of the oral cavity (29.4%), followed by accessory sinuses (13.9%) and larynx (13.5%). Nasopharyngeal cancer affected young people, with 34.5% of affected patients aged between 10 and 19 years. The commonest histopathological type was squamous cell carcinoma (49.6%). Majority (47.6%) of patients presented at stage IV. Conclusion: The commonest HNCA is oral cancer. Majority of patients with HNCA are presenting late calling for public health education to raise awareness and promote early detection.