Adenoid Cystic Carcinoma of Distal Trachea: a Case Report (original) (raw)
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Adjuvant Radiotherapy in Primary Adenoid Cystic Carcinoma of Trachea- A Case Series
Asian Pacific Journal of Cancer Biology
Objective: Only 1% of all malignancies of the respiratory system are adenoid cystic carcinoma (ACC) of the trachea. ACC’s clinical course is frequently lengthy. Most patients first experience dyspnea, which looks like asthma or chronic bronchitis. The primary treatment choice is surgical resection followed by radiotherapy due to the small surgical margins of the tumor. When surgery is not an option, most cancers respond to radiotherapy, which frequently produces prolonged periods of remission. Method: We present three cases of primary ACC of the trachea. One case involved a 49-year-old man who had tracheal ACC treated surgically and then with radiation. Another 65-year-old female patient underwent surgical resection and adjuvant radiotherapy to treat her recurrent metastatic posterior thoracic wall tumor. At one month follow-up, our patient showed no evidence of disease, and a 38-year-old male presented with complaints of dry cough, breathlessness, and hemoptysis. Bronchoscopy showe...
Adenoid Cystic Carcinoma of Trachea Treated with Radical Radiotherapy: A Case Report
2015
Adenoid cystic carcinoma of trachea is rare and is associated with prolonged survival and better prognosis. It is often misdiagnosed as chronic bronchitis or asthma. The ideal treatment option is surgical resection with tracheal reconstruction followed by adjuvant radiotherapy. Post operative radiotherapy may decrease the risk of local recurrence, but has no effect on the survival. In this report, we present a case of a patient with adenoid cystic carcinoma of trachea treated only by radical radiotherapy by intensity modulated radiotherapy technique. Initial coring followed by radical radiotherapy may be considered in unresectable cases or in those patients who refuse surgery. Radical radiotherapy may alone treat adenoid cystic carcinoma of trachea without any surgical morbidity, indicating that adenoid cystic carcinoma may be relatively and not absolutely resistant to radiation. There is no role of chemotherapy in adenoid cystic carcinoma.
A case of adenoid cystic carcinoma of trachea: treatment complications and radiotherapy role
Journal of Contemporary Brachytherapy
Purpose: Adenoid cystic carcinoma (ACC) of trachea is a relatively rare malignant neoplasm, for which there is a lack of prospective clinical trials investigating treatment effectiveness. Most of the authors prefer surgical resection followed by post-operative radiation therapy in case of incomplete excision. There are no available prospective data on post-relapse treatment. Case presentation: The current paper presents a case of tracheal ACC in a young woman, treated solely with surgical resection without radiotherapy due to postoperative neurological complications requiring additional diagnostics, management, and treatment. As a complication itself, spinal cord dysfunction after tracheal surgery is extremely rare, in which radical radiotherapy and brachytherapy were successfully administered after disease recurrence. Conclusions: Lack of post-operative radiotherapy resulting from neurological complications could be a reason for ACC recurrence in our patient. Administration of radiotherapy after incomplete resection of recurrent disease may lead to long-term locoregional control.
Definitive radiotherapy for inoperable adenoid cystic carcinoma of the trachea: A rare case report
Lung India, 2017
She was being treated for bronchial asthma without any relief in the last 9 months. Presently, her symptoms worsened with increasing shortness of breath for which she was investigated. Her computed tomography (CT) scan thorax [Figure 1] showed an exophytic mass from mid-trachea to 3.4 cm proximal to carina causing marked luminal obstruction. It is indenting on adjacent esophagus, brachiocephalic artery with loss of fat planes. There is no enlarged lymph node. On bronchoscopy, a pinkish polypoidal tracheal growth measuring 1 cm × 1.5 cm in the lower third of trachea was seen with near total luminal obstruction. Histopathology confirmed it as ACC [Figures 2a and b]. No distant metastasis was seen.
Adenoid Cystic Carcinoma of the Trachea
Journal of Bronchology, 1999
Objective: Primary tracheal tumors are rare, occurring in 0.2 per 100,000 persons per year. Adenoid cystic carcinoma (ACC) is the second most common histologic type of tracheal malignancy. Its clinical behavior is different from the other tracheal neoplasms and thus should be studied separately. Study De-signliUethods: Retrospective review of the medical records of six patients with tracheal ACC who were treated at University Hospitals of Cleveland between 1971 and 1996 and literature review. ResultslConclusion: Tracheal ACC is an indolent tumor that affects people at any age but has a peak incidence i n the fifth decade. There is a nearly equal male-to-female ratio. Almost half of tracheal ACCs occur in the proximal trachea, accounting for the most common presenting symptoms: dyspnea, cough, and hoarseness. Because of the hoarseness, patients are often referred to an otolaryngologist. Complete resection provides the best chance for increased survival. Neutron beam radiotherapy holds promise for adjuvant therapy.
Adenoid cystic carcinoma of the trachea: case report and literature review
2020
Tracheal cancer is a rare neoplasm that accounts for only about 0.1% of all respiratory tract tumors. Cysticadenoid carcinoma (or cylindroma) represents the second histological type of tracheal tumors in order of frequency. These lesions are characterized by slow local growth, perineural invasion, and potential local and distant recurrence. Complete surgical resection offers the patient a better opportunity of prolonged survival or complete remission. The addition of photon- or electron-beam radiation seems to influence local control but does not affect survival. In this paper, we report a clinical case describing the characteristics and management of adenoid cystic carcinoma of the trachea in 59 years-old men.
Journal of Medical Case Reports, 2019
Background: Adenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease. Case presentation: We report a case of an 82-year-old white man affected by primary adenoid cystic carcinoma of the trachea, treated with debulking surgery and radiotherapy on the residual disease. A three-dimensional conformal radiation therapy was conducted. The total dose amounted to 70 Gy, administered in 35 fractions of 2 Gy. The medium doses given to the esophagus and lungs were 23 Gy and 4.2 Gy respectively. The maximum dose delivered to the spinal cord was 31 Gy with satisfactory results in terms of local control of the disease. Conclusion: A combined approach of surgical resection followed by radiotherapy on the residual disease provided an excellent result in terms of disease control, quality of life, and overall survival in a patient with locally advanced tracheal adenoid cystic carcinoma.
Primary Adenoid Cystic Carcinoma of the Trachea: A Case Report of a Twelve Year Survivor
The Keio Journal of Medicine, 1995
Malignant tumors arising from trachea are not common. This paper presents an example of primary tracheal adenoid cystic carcinoma treated by surgical resection with good prognosis. A 46-year old woman presented with a short history of dyspnea. Five months before the onset of dyspnea, the patient had mild wheezing. She had no history of smoking. Physical examination suggested primary tracheal tumor. The patient underwent a V-shaped resection of 3.5cm of trachea followed by reconstruction with the trough method. Histological examination revealed adenoid cystic carcinoma. Adjuvant chemotherapy was indicated with 50mg of adriamycin postoperatively. The patient has done well for 12 years with no further treatment. The tumor was an adenoid cystic carcinoma that was slow-growing, infiltration of mucus membrane was few and growth fraction (mitotic index was less than 1%) was low. Those were considered the reason for good prognosis.
Emergency Tracheal Surgery for Adenoid Cystic Carcinoma: A Rare Entity
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2018
Primary tumours of the trachea are rare. Adenoid cystic carcinoma (ACC) constitutes less than 1% of these tumours. They occasionally masquerade as asthma. We are presenting a case of a young female, who had been treated for 3 years as asthma. She presented in emergency with severe respiratory difficulty, stridor and decreasing saturation of 85% on room air. Two weeks back, she had a CT scan in a local hospital, but they did not notify the tracheal mass. Her clinical picture and CT scan helped us diagnose the case. She was treated in emergency with primary resection of tracheal mass and anastomosis. The tumor was diagnosed as ACC. Postoperative recovery was uneventful. Continuity of the trachea was restored and adjuvant radiotherapy was given.
Future oncology, 2019
Aim: Adenoid cystic carcinoma is a rare tumor of head and neck region and its development in the thoracic region is even less frequent. This implies the absence of guidelines for therapeutic management and a consequent case-by-case approach. The role of radiotherapy is not yet clearly defined, but intensity-modulated radiotherapy allows for improved organ-at-risk sparing. Materials & methods: We have collected the cases of four patients treated at our institutions by the means of intensity-modulated radiotherapy, after endoscopic resection. Results & conclusion: Patients treated achieved long-term disease control of about 5 years, with a minimal acute toxicity. Longer follow-up is needed to drain conclusion on the impact of this treatment on overall survival.