Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials (original) (raw)
Related papers
Recent Patents on Inflammation & Allergy Drug Discovery, 2018
Background: Punica granatum L. (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substantial attention among researchers due to their promising biological activities including anti-inflammatory, antibacterial, antidiarrheal, immune modulatory, antitumor, wound healing and antifungal that have been attributed to various constituents of seeds, bark, juice, pericarp, and leaf of this tree across the globe. The phenolic compounds of pomegranate have been documented to possess numbers of prophylactic and therapeutic utilities against various pathological infections as well as non-infectious disorders. Objective: The current review expedites the pharmacological role of Punica granatum L. in curing elements related to infectious and non-infectious disorders. Method: The current review is based on literature and patents already available on various scientific databases highlighting the role of Punica granatum along with its therapeutic potentials against infectious and non-infectious disorders. The databases included under study were PubMed, Med line, PubMed Central, Science Direct and few other scientific databases. The information obtained through these diverse databases is compiled, critically interpreted and presented in the current study. Results: Multi-dimensional beneficial application of pomegranate plant is recorded. The pomegranate seed oil has phytoestrogenic compounds and the fruit is rich in phenolic compounds with strong antioxidant activity. The fruit and bark of pomegranate are used against intestinal parasites, dysentery, and diarrhea in different animals and human models. Since the ancient time the juice and seeds had considered the best therapy for throat and heart disorders. Ellagic acid is one of the main components of pomegranate with potent antioxidant activity. Results from different studies reported that Punica granatum L or its byproducts can be used as natural food additives in human and animal nutrition in order to boost immunity, microbial safety and provide the housing environment without affecting body weight gain. In addition, Punica granatum L. byproducts can modulate immune function and gut microbiota of broiler chickens as well as reduce the odorous gas emissions from ex-creta. Naturally occurring polyphenols in a pomegranate can be a potential alternative medicine for the prevention of avian Colibacillosis diseases and can also be used as an intestine astringent to relieve diarrhea and enteri-tis in chickens. Conclusion: The present review gives the insight towards major components of pomegranate as well as their pharmacological activities against pathological disorders. In spite of many beneficial properties of Punica granatum L., more research evidence on a molecular basis is needed to find out the molecular mechanism of action in various animals and human models to validate the usefulness of Punica granatum L. as a potent therapeutic agent.
PUNICA GRANATUM: A REVIEW ON PHARMACOLOGICAL AND THERAPEUTIC PROPERTIES
International Journal
A wide range of medicinal plant parts is used as raw drugs and they possess varied medicinal properties. The different parts used as raw drugs include root, stem, flower, fruit, twigs exudates and modified plant organs. The Punica granatum is a native shrub of occidental Asia and Mediterranean Europe that has a rich history of traditional use in medicine. For centuries, the barks, leaves, flowers, fruits, and seeds of this plant have been used to treat various diseases. The aim of this present review is to throw light on the therapeutic utility of various parts of pomegranate.
A review on phytochemistry and pharmacological profile of punica granatum
Journal of Current Pharma Research
Pomegranate (Punica granatum L), in addition to its ancient historical applications, has been used in several systems of medicine for a variety of diseases and disorders. Pomegranate juice is regarded as a polyphenol-rich juice with high antioxidant capacity. Pomegranate juice has been shown to exert significant antiatherogenic, antioxidant, anti-carcinogenic, and anti-inflammatory effects in several human and marine models. Pomegranate is potent antioxidant, anti-carcinogenic, and antiinflammatory properties other potential applications include male infertility, infant brain ischemia, Alzheimer's disease, obesity, arthritis. The aim of the present review is to discuss the cumulative evidence, which suggests that consumption of pomegranate possesses a diverse array of biological activities and may be helpful in the prevention of some inflammatory mediated diseases, including cancer.
Therapeutic applications of pomegranate (Punica granatum L.): a review
2008
The pomegranate, Punica granatum L., is an ancient, mystical, unique fruit borne on a small, long-living tree cultivated throughout the Mediterranean region, as far north as the Himalayas, in Southeast Asia, and in California and Arizona in the United States. In addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. The synergistic action of the pomegranate constituents appears to be superior to that of single constituents. In the past decade, numerous studies on the antioxidant, anticarcinogenic, and anti-inflammatory properties of pomegranate constituents have been published, focusing on treatment and prevention of cancer, cardiovascular disease, diabetes, dental conditions, erectile dysfunction, bacterial infections and antibiotic resistance, and ultraviolet radiation-induced skin damage. Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis, and obesity.
Medicinal Uses Of Punica Granatum and Its Health Benefits
Pomegranate has been used for thousands of years to cure a wide range of diseases across different cultures and civilizations. It has great nutritional values and numerous health benefits. Pomegranates as a Treatment for Cancer, Osteoarthritis and Other Diseases. The pomegranate has been used in natural and holistic medicine to treat sore throats, coughs, urinary infections, digestive disorders, skin disorders, arthritis, and to expel tapeworms. However, modern research suggests that pomegranates might be useful in treating such serious conditions as prostate cancer, skin cancer, osteoarthritis, and diabetes. Studies also show that pomegranate seeds might help rid the digestive system of fats. Clinical research shows that pomegranates, when part of a healthy diet, might help prevent heart disease, heart attacks and strokes. This is because pomegranates have the potential to thin the blood, increase blood flow to the heart, reduce blood pressure, reduce plaque in the arteries, and reduce bad cholesterol while increasing good cholesterol. A decotion of seed is used to treat syphilis. Juice used to treat jaundice and diarrhoea. Juice of flower is used to treat nose bleeds. The fruit pulp and the seed are stomachic. Dried, pulverized flower buds are employed as a remedy for bronchitis.
Herbal medicines as the major remedy in traditional system of medicine have been used in medical practices since antiquity. In addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. The objective of the present study was to investigate the presence of various phytochemicals from the ethanolic, aqueous and chloroform extracts of Punica granatum peel, whole fruit and seeds. The three different extracts from peel were found to contain Triterpenoids, Steroids, Glycosides, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from whole fruit were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from seeds were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Tannins, Carbohydrate & Vitamin C. The generated data from the three different extracts of Punica granatum peel, whole fruit & seeds provided the basis for its wide uses in the traditional & folk medicines.
Journal of Health and Allied Sciences NU
Herbal medicines as the major remedy in traditional system of medicine have been used in medical practices since antiquity. In addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. The objective of the present study was to investigate the presence of various phytochemicals from the ethanolic, aqueous and chloroform extracts of Punica granatum peel, whole fruit and seeds. The three different extracts from peel were found to contain Triterpenoids, Steroids, Glycosides, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from whole fruit were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Flavonoids, Tannins, Carbohydrate & Vitamin C. The three different extracts from seeds were found to contain Triterpenoids, Steroids, Glycosides, Saponins, Alkaloids, Tannins, Carbohydrate & Vitamin C.The generated data from the three different extracts of Punica granatum peel, whole fr...
Review Article: Pharmacognosy and Pharmacological Uses of Punica protopunica
2022
Punica granatum provides a number of health advantages. Various disease risk factors, such as hypertension, high cholesterol, oxidative, hyperglycemia, and inflammatory activity, can be prevented or treated using pomegranates. It has been established that some pomegranate constituents, such polyphenols, may have antioxidant, anti-inflammatory, and anticarcinogenic properties. Pomegranate juice has greater antioxidant potential than red wine and green tea, which are produced by hydrolysable tannins and hydrosable tannins. Pomegranate juice helps lessen lipid peroxidation, free radicals, and macrophage oxidative stress. Pomegranate fruit extract also inhibits cell division and triggers apoptosis, which may contribute to its anticarcinogenic benefits. Additionally, ellagitannins prevent the promoter suppression of several inflammatory indicators and their production.