Cell-mediated and humoral immune responses in diabetic patients with periodontitis (original) (raw)
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Cell-mediated and humoral immune response in diabetic patients with periodontitis.
Anil, S., P. Remani, et al. (1990). "Cell-mediated and humoral immune response in diabetic patients with periodontitis." Oral surgery, oral medicine, and oral pathology 70(1): 44-48. Cell-mediated and humoral immune responses were assessed in 50 patients with type II or non-insulin-dependent diabetes mellitus and 50 nondiabetic patients with periodontitis. The values were compared with those of 50 age and sex-matched control subjects. The cell-mediated immunity assessed by enumerating the total and high-affinity rosette-forming cells of the patient did not show any significant variation from that of the normal control subjects. The humoral immune response was assessed by estimating serum immunoglobulins G, A, M, D, and E by single radial immunodiffusion. Except IgD, all other immunoglobulins were found to be elevated significantly in both diabetic and nondiabetic subjects. The alteration in humoral immune response may be the cause or the effect of periodontitis. The defective host response reported in diabetic patients may be responsible for the increased incidence of periodontitis in diabetic patients as compared to nondiabetic patients.
Journal of Natural Sciences Research, 2015
Background: Periodontitis is a bacterial infection of tooth-supporting tissues. The host reacts to this bacterial challenge by activating its defense mechanisms; the immune responses can be mediated either by humoral factors or by lymphocytes. Recently studies found that periodontitis might be related to several systemic diseases especially diabetes mellitus. Objectives: The current study was established to evaluate the alteration in humoral immune response in chronic periodontitis with type 2 diabetes mellitus as compared controls. Subjects and Methods: A total of 30 patients and 20 controls were included in the study. Blood samples were collected from each subject to determine serum concentrations of (IgA, IgG, IgM, C3 and C4) by single radial immune diffusion method. In this study, clinical examination included plaque index, gingival index, probing pocket depth, clinical attachment level and bleeding on probing. Results: serum concentrations of IgG and IgA are significantly higher (p< 0.05) in patients than healthy control, and serum concentration of C3 is significantly less than corresponding value of control (p< 0.05), while there are no significant (p> 0.05) differences in serum concentrations of each IgM and C4 between the patients and controls. Furthermore there are no significant (p> 0.05) correlation between serum immunological parameters and periodontal parameters. Conclusion: These findings corroborate the thought that the humoral immune response plays a crucial role in the pathogenesis of periodontitis with type 2 DM. In addition, elevated antibody levels may explain why diabetes aggravates periodontitis.
An Immunological Evaluation of Type II Diabetic Patients with Periodontal Disease
Journal of Diabetes and its Complications, 1999
Peridontal disease is a frequent complication of study of NADPH neutrophil superoxide production, neutrophil chemotaxis, lymphocyte diabetes, and diabetic subjects often exhibit decreased immune response with increased subpopulations, immunoglobulins and complement. Diabetic patients showed significant susceptibility to infection. We evaluated the possible relationship between immune response differences compared with controls regarding ABL (30.6 Ϯ 14.7% versus 17.6 Ϯ 4.3%; p Ͻ 0.0001) and periodontal disease in 40 type II diabetic patients, mean Ϯ SD) age 59 Ϯ 8 years and mean and the T-helper/T-suppressor ratio (2.3 Ϯ 1.0% versus 1.8 Ϯ 0.8%; p Ͻ 0.05). Other parameters of disease duration 17 Ϯ 4 years, with good metabolic control (mean fasting plasma glucose, 10.5 Ϯ 3.8 cell-mediated immunity and humoral immune response did not show any significant variations. mM/L, mean HbA 1c 8.1 Ϯ 1.66%), and in 40 age and gender-matched controls. Interproximal alveolar No correlation between immunological and radiographic analysis parameters were found. bone loss (ABL), as the percentage of bone loss from the cement enamel junction (CEJ) to the apex, Further studies are needed to verify the exact role played by immunological factors in type II diabetic was measured with a modified Schei ruler at the deepest point on the mesial/distal surface of the patients with periodontal disease. (Journal of Diabetes and Its Complications 13; 1: 23-30, teeth, except third molars, on a panoramic radiograph. Immunological evaluation involved 1999.)
Immunoglobulins in the saliva of diabetic patients with periodontitis.
Anil, S., P. Remani, et al. (1995). "Immunoglobulins in the saliva of diabetic patients with periodontitis." Annals of dentistry 54(1-2): 30-33. The study was conducted to estimate the concentration of immunoglobulins in the saliva of diabetic and nondiabetic patients with periodontitis. The salivary immunoglobulins G, A and M (IgG, IgA, IgM) were determined in 50 patients with type II or noninsulin dependent diabetes mellitus (NIDDM) and 50 non diabetic patients with periodontitis. The values were compared with that of 50 age and sex matched controls. IgG, IgA were found to be significantly increased in diabetic patients with periodontitis, compared to nondiabetic patients and controls. Though an increase in IgM was found in diabetic patients it was not significant. The altered immune response observed may be due to the response to a greater antigenic challenge which in turn may be responsible for the increased incidence of periodontitis in diabetic patients. Further studies in this field may help to establish this association.
Circulating immune complexes in diabetic patients with periodontitis.
Anil, S., P. Remani, et al. (1990). "Circulating immune complexes in diabetic patients with periodontitis." Annals of dentistry 49(2): 3-5, 45. Circulating immune complexes were estimated in the sera of 50 patients with Type II or non-insulin-dependent diabetes mellitus (NIDDM) and 50 nondiabetic patients with periodontitis. The values were compared with that of 50 age- and sex-matched controls. There was a significant rise in circulating immune complexes (CIC) in both the groups of patients compared to controls. The levels of CIC were significantly higher in diabetic patients with periodontitis compared to nondiabetics. The study shows that the circulating immune complexes may have a role in the pathogenesis of periodontal disease in diabetic patients.
Serum immunoglobulin levels in type 2 diabetes patients with chronic periodontitis
The journal of contemporary dental practice, 2010
The association between diabetes and periodontal disease has been well documented. Periodontitis is associated with alterations in immune responses in both diabetic and nondiabetic subjects. While diabetes is considered to be a risk factor for periodontal disease progression, few studies have demonstrated an association between the level of glycemic control and periodontal disease. Although poor glycemic control is significantly associated with poor periodontal health, few studies have been performed in Saudi Arabia to evaluate the immune responses in poor and better glycemic control and its effect on periodontal tissue. The aim of this study is to assess serum immunoglobulin levels (IgA, IgG, IgM) in type 2 diabetic (poor control and better control) and nondiabetic subjects with chronic periodontitis. A total of 105 female patients were included in the study and they were divided into three groups, with 35 patients in each group. Group 1 was comprised of cases of diabetes exhibitin...
Immunoglobulin concentration in gingival tissue of type 2 diabetic patients with periodontitis
Indian Journal of Dental Research, 2006
Anil, S. (2006). "Immunoglobulin concentration in gingival tissue of type 2 diabetic patients with periodontitis." Indian journal of dental research : official publication of Indian Society for Dental Research 17(4): 151-154. BACKGROUND: Diabetes mellitus is considered as a risk factor for the initiation and progression of periodontal disease. The diabetic patients often exhibit decreased immune response and increased susceptibility to infection. In the present study, a quantitative estimation of the gingival tissue immunoglobulin concentrations in diabetic and non diabetic subjects with periodontitis was assessed and compared with that of clinically healthy gingiva. METHOD: 40 gingival tissue samples obtained from 20 diabetic (Type 2) and 20 non-diabetic subjects were subjected to quantitative estimation of immunoglobulins G, A, and M. The data thus obtained were compared to the level of immunoglobulin found in clinically healthy gingiva. RESULTS: The IgG and IgA level in the tissues of both diabetic and non-diabetic subjects with periodontitis were found to be significantly higher than that of healthy subjects. The diabetic group also showed a significantly higher IgG and IgA levels compared to the non-diabetic group with periodontitis. CONCLUSION: These findings support the concept that the humoral immune response plays an important role in the pathogenesis of periodontal disease in diabetics. The significantly higher levels of immunoglobulin in the gingival tissues might be a protective mechanism against the increased bacterial challenge in diabetic subjects.
Co-relating HbA1c and serum IgA in diabetic and non-diabetic patients with and without periodontitis
Asian Journal of Medical Sciences, 2014
Objective: Diabetics are more susceptible to the infections than the non-diabetics (healthy) one, suggesting that the immunologic capability may be unbalanced in diabetics. Periodontitis is associated with alterations in immune responses in both diabetic and non-diabetic subjects. Till date various attempts has been taken to monitor host immunological response of diabetic individuals. Therefore the need to study the local immune response in inflamed gingival showing Periodontitis is apparent. Since till date there are no well documented and significant baseline studies are available on the functional capacities of the lymphoid cells present in gingiva of the periodontitis patients, a study to check the level of immunoglobulin was investigated. Methodology: A study was carried out where HbA1c, Random Blood Sugar and Serum IgA level were assessed in 60 patients from the OPD of RCDSR. 15 patients each belonging to the four groups diabetic with periodontitis, diabetic without periodon...
The Journal of Contemporary Dental Practice, 2013
Aim To evaluate and compare the serum IgM level in diabetic and nondiabetic patients with chronic periodontitis. Materials and methods A total of 60 patients were selected for the study and divided into four groups, diabetic with periodontitis, diabetic without periodontitis, nondiabetic with periodontitis and nondiabetic without periodontitis (control) were analyzed for the quantitative estimation of serum immunoglobulins M by turbidimetric immunoassay. The serum of the diabetic and nondiabetic patients was evaluated and turbidimetric method was used for immunological assay by using Quantia IgM turbidimetric immunoassay for estimation of immunoglobulin IgM in human serum. The data for the level of immunoglobulin thus obtained were compared with clinically healthy patient taken as control. Sugar level was estimated the by checking the random blood sugar level by glucose test kit based on end point and kinetic assay and compared with the HbA1c percentage of the patients, by using Nyc...