Estrogen and different aspects of vascular disease in women and men (original) (raw)
2006, Circulation research
AI-generated Abstract
Considerable evidence indicates that sex hormones have a significant influence on cardiovascular physiology and pathology, particularly emphasizing the role of estrogen receptor-alpha (ESR1) in vascular disease. Recent findings highlight gender differences in smooth muscle cell (SMC) behavior, with men showing reduced ESR1 expression and increased differentiation markers compared to women, suggesting a potential mechanism for gender-related disparities in vascular disease severity. Furthermore, unique risk factors affecting women contribute to their poorer clinical outcomes in comparison to men. This analysis calls for deeper investigation into ESR1's role in SMC function and its implications for therapeutic approaches targeting vascular diseases.
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