Surgical Management of Thoracolumbar Kyphosis in Patients with Mucopolysaccharidosis: A Systematic Review (original) (raw)

Spine, 2017

Abstract

Systematic Review OBJECTIVE.: To determine the indications and outcomes for surgical treatment of thoracolumbar kyphosis in patients with mucopolysaccharidoses (MPS) in order to define future studies. Improvements in the medical treatment of MPS have increased lifespan and improved quality of life for many patients, but with no effect on thoracolumbar kyphosis. A greater number of these challenging patients may now be considered spinal surgical candidates. In accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a PubMed database search was conducted using relevant keywords to identify articles describing MPS patients with thoracolumbar kyphosis treated surgically. Information was collected regarding demographics, indications for surgery, surgical details and outcomes. 16 articles describing 58 patients were included for review. The median age at surgery was 7 years (range 2.4 - 65 years) and median follow-up was 3.7 years (range...

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