Early hearing threshold changes and peculiarities of audiometric assessments among patients in a drug-resistant tuberculosis treatment center (original) (raw)
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Jornal Brasileiro de Pneumologia
Objective: To use baseline audiogram parameters in order to ascertain whether drug-resistant tuberculosis (DR-TB) has effects on hearing, as well as to describe the configurations of the audiograms and to determine whether there are parameters that can be associated with those configurations. Methods: This was a prospective study involving patients diagnosed with DR-TB at a tuberculosis treatment center in the state of Ogun, in Nigeria. The patients included in the study were submitted to pure tone audiometry at baseline (within two weeks after treatment initiation). For comparative analyses, data regarding demographic and clinical characteristics were collected from the medical records of the patients. Results: The final sample comprised 132 patients. The mean age of the patients was 34.5 ± 12.6 years (range, 8-82 years), and the male:female ratio was 2:1. Of the 132 patients, 103 (78.0%) resided in neighboring states, 125 (94.7%) had previously experienced antituberculosis treatme...
F1000Research
Background: The objective of this study was to test the validity of automated audiometry as a method of hearing examination in patients with multidrug-resistant tuberculosis. Methods: This was a cross-sectional comparative study with a retrospective approach, using patient medical records. Patients with multidrug-resistant tuberculosis (MDR-TB) were recruited based-on medical records that met the inclusion and exclusion criteria at the Pulmonology outpatient unit, then referred to the Otorhinolaryngology outpatient unit of the Dr. Soetomo Academic Medical Center. The subjects’ hearing function was measured with two different devices (automated audiometer and conventional audiometer) before being given anti-tuberculosis drug therapy (aminoglycoside injection) as ototoxicity monitoring from July to December 2019 period. Sensitivity and specificity analysis was used to assess the validity of the test. Results: A total of 36 patients (72 ears) were included. The comparison test results ...
The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis
Revista da Sociedade Brasileira de Medicina Tropical
A total of 771 cases of multidrug-resistant tuberculosis (MDR-TB) were reported in Brazil in 2014. Treatment of MDR-TB with aminoglycosides can produce serious side effects such as permanent and irreversible hearing loss, which occurs in 5-64% of cases, and severely compromise patient quality of life. The goal of this research was to evaluate auditory and vestibular side effects in patients treated for MDR-TB and to identify associations between these complaints and the type of aminoglycoside used. We performed a retrospective review of 599 medical records from patients with MDR-TB who were treated at the Hélio Fraga/Fiocruz Reference Center between 2006 and 2010. Cases without auditory or vestibular complaints and patients who were not treated with aminoglycoside drugs were excluded from the study. Of 164 eligible cases, 55 (33.5%) reported an auditory or vestibular complaint and medication was subsequently suspended, although hearing damage was not confirmed in all cases. Audiomet...
Ototoxic hearing loss in the multi-drug resistant tuberculosis era
Journal of Islamabad Medical & Dental College, 2022
Objective: To determine the prevalence of hearing loss in tuberculosis patients using Ototoxic medicines and association with demographic and clinical variables. Methods: This cross sectional study recruited a sample of n= 65 diagnosed cases of tuberculosis on ototoxic chemotherapy, of both genders, aged 12 to 70 years, using non-probability convenience sampling. Study was conducted at Audiology Department of Civil Hospital Bahawalpur, over a period of 6 months from 1st May, 2019 to 31st October 2019. Screening was performed using medical history sheet, otoscopy and hearing assessment. Data collected was analyzed using SPSS- Version 21.0. Results: Results revealed a gender proportion of 43 (66.2%) males and 22(33.8%) females with mean age of 35.87+9.35 years. The prevalence of hearing loss was 23.1% (n=15) with mild hearing loss in 73.33% cases and moderate hearing loss 26.67%. Hearing loss was associated with drug, its duration and associated symptoms of tinnitus and vertigo with p...
The South African journal of communication disorders = Die Suid-Afrikaanse tydskrif vir Kommunikasieafwykings, 2016
The increased incidence of multi-drug-resistant tuberculosis (MDR-TB) and the consequent use of aminoglycosides with their ototoxic potential necessitate a better understanding of the audiological pattern of infected patients. To describe the occurrence and nature of hearing loss in patients with MDR-TB receiving aminoglycosides over a period of 6 months. Baseline and five consecutive monthly audiological assessments were conducted on 52 adults at a hospital in KwaZulu-Natal. A longitudinal descriptive study was implemented. A conventional audiological test battery, extended high frequency audiometry and otoacoustic emission testing were conducted. Data were analysed using SPSS version 19 statistical software package. Decreased hearing was the most common audiological symptom experienced. Bilateral sensorineural hearing loss was predominant. Ototoxic hearing loss was noted in 27 participants (52%) in 1 month post-treatment. Hearing loss progressed from mild to moderate at post-treat...
A case of profound hearing loss developing in a patient with previously normal hearing following drug treatment for drug-resistant tuberculosis is reported. At present there are no specific audio-vestibular monitoring recommendations in most drug-resistant tuberculosis programs, and patients are at a high risk of developing irreversible ototoxicity before it is discovered. The report emphasizes the need for frequent and regular monitoring of the audio-vestibular system during treatment for drug-resistant and multi-drug resistant tuberculosis, the need for policy support for such monitoring and the need to develop innovative solutions to the financial and logistical challenges that such policies and monitoring would create.