Rosmarinus officinalis L. ameliorates titanium dioxide nanoparticles and induced some toxic effects in rats' blood (original) (raw)

Environmental science and pollution research international, 2017

Abstract

Titanium dioxide nanoparticles (TiO NPs) have been widely used as a white pigment in food and drugs. The most important route of human exposure to TiO is through food and drug products containing TiO additives. This study investigates the efficacy of an oral traditional use of rosemary extract in ameliorating some toxic effects induced on blood of TiO NP-intoxicated rats. Rats were given rosemary extract via intragastric administration 1 h before the intragastric administration of 100 mg/kg/day TiO NPs (10 nm) for 60 days. TiO NPs significantly increased serum cholesterol, glucose, and triglyceride levels of rats. They also induced significant oxidative stress and inflammatory and caused DNA damage in peripheral blood leukocytes. The rosemary extract appears to have a significant protective effect by lowering glucose level properties, restoring the lipid profile and showing an antioxidative, anti-inflammatory, and antigenotoxic properties against TiO NPs toxicity. In conclusion, thi...

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