Effects of artificial depletion of the bile acid pool in man (original) (raw)
In order to elucidate the relationship between bile acid pool size and cholesterol saturation index of fasting state gall bladder bile, we artifically depleted the bile acid pool in 12 healthy volunteers. Bile acid pool size decreased from 7-6±0*9 to 5 8±0 7 mmol (mean+SEM, p<0.01), and saturation index of fasting state gall bladder bile increased from 0 93±0*07 to 1-18±0-07 (p<0001). There was no alteration in saturation index of basal or stimulated hepatic bile. There was no change in gall bladder storage of basal hepatic bile, nor in the proportion of the bile acid pool stored in the gall bladder. The bile acid mass in the gall bladder fell from 4 9±0-5 to 3-4±0*4 mmol (p<0-05) and phospholipid mass from 1*6±0-3 to 1-2±0-2 mmol (p<O0O5), but there was no change in cholesterol mass. The gall bladder volume fell from 30±4 to 18±2 ml (p<0.01). These results suggest that artificial depletion of the bile acid pool increased saturation index of fasting state gall bladder bile without altering saturation index of basal or stimulated hepatic bile; it probably increased the ratio of basal: stimulated hepatic bile within the gall bladder by decreasing gall bladder storage of stimulated hepatic bile. concept is correct, it implies that the gall bladder
Loading Preview
Sorry, preview is currently unavailable. You can download the paper by clicking the button above.