Safety, anti-inflammatory and analgesic assessments of methanolic extract of Musa paradisiaca peel in Sprague Dawley rats (original) (raw)
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The methanol extract of Musa paradisiaca (MEMP) at the dose of 200 and 400 mg/kg orally was tested for anti-inflammatory activity in some acute models viz. xylene induced ear lap oedema, carrageenan induced paw oedema and dextran induced paw oedema model. Ibuprofen at the dose of 50 mg/kg was used as standard. MEMP showed dose dependent activity against all the three models and the results were significant (p<0.05) compared with the control group.
African journal of pharmacy and pharmacology
This study investigated the antiulcer activity of aqueous extract of unripe Musa paradisiacal (plantain) peels in rats using ethanol, aspirin, indomethacin and pyloric ligation-induced ulcer models. Fresh peels of M. paradisiaca were extracted in hot water and the yield lyophilised. Distilled water, standard drugs and extract were injected intraperitoneally before inducing ulcer. Lethality test and quantitative phytochemical analyses were also carried out using standard techniques. Results showed that the extract at 50, 100 and 200 mg/kg wt offered 73.87, 80.18 and 81.98% protection, respectively against ethanol-induced ulcer, whereas cimetidine (50 mg/kg) produced 72.07% ulcer protection. There was no significant difference (p > 0.05) between the various groups. The extract also inhibited aspirin-induced ulcer whereas omeprazole (20 mg/kg) significantly enhanced aspirin-induced ulcer. Similar to cimetidine, the extract did not inhibit indomethacin-induced ulceration. Extract (50, 100, and 200 mg/kg) and cimetidine (50 mg/kg) inhibited pyloric ligation-induced ulcer by 100 and 75%, respectively. Findings suggest antiulcerogenic potentials of the extract, thereby supporting its ethnomedicinal use as antiulcer agent. Up to 5000 mg/kg of extract did not cause mortality of the animals, indicating safety of the extract. The extract was rich in flavonoids (1.40 ± 0.02 mg/100 g).
Anti-Inflammatory and Analgesic Activity of Musa balbisiana Peels In Vivo
Borneo Journal of Pharmacy
Musa balbisiana Peels (MBP) contains high levels of flavonoids, alkaloids, tannins, saponins, and triterpenoids. Flavonoids function to slow down the inflammatory process by inhibiting the arachidonic acid, forming prostaglandins, and releasing histamine. This study aimed to examine the anti-inflammatory and analgesic effects of MBP decoction. This study used the Winter method for anti-inflammatory assay by induction of carrageenan on the soles of rat's feet and Sigmund's method for analgesic assay with intraperitoneal induction of acetic acid in mice. Group I as a negative control, group II as a positive control with diclofenac sodium, group III as a low dose (200 mg/kg BW of MBP), group IV as a medium dose (400 mg/kg BW of MBP), and group V as a high dose (800 mg/kg BW of MBP decoction). The percentage of inhibition in the anti-inflammatory test in rats for groups II, III, IV, and V was 34.43%, 17.68%, 25.53%, and 25.4%, and the percentage of effectiveness for the anti-inf...
STUDY OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF MUSA SP Peels (Cavendish)
The various parts of banana, Musa acuminate, such petiol and peel is known to have medical benefits. Banana peels make up 40% of the fresh fruits and is a major agriculture waste. This research investigated the anti-inflammatory and analgesic activities of banana peels specifically the potential of Cavendish variety which is popularly consumed. In this study, two different doses, 200 mg/kg and 400 mg/kg of ethanolic peel extracts were given to the rats via oral administration. The analgesic activity was then evaluated by using Eddy's hot plate method to measure the latency time of the rats on the hot plate. As for anti-inflammatory study, the test were evaluated by measuring the inflammation induced subcutaneously by using 1% of 0.05 ml of formalin into the sub plantar region of on the left hind paw of the rats. The group and the results were expressed in " Mean ± SEM " as statistical identifiable value and p<0.05 were considered statistically significant. Hot plate test showed vast analgesic reaction in the extract of 400 mg/kg treated rats at the 60 th minutes which is comparable to positive control of diclofenac sodium. The anti-inflammatory test showed vast inflammatory action at the 6 th hour which is comparable to the positive control. Largest inhibition of inflammation was seen at the 6 th hour which was 63% in rats received 400mg/kg extract. These findings indicated that the Cavendish peel's exhibit analgesic and anti-inflammatory activities.
Anti-Ulcer Activities of Methanolic Extract of Musa Paradisiaca
2021
Musa paradisiaca (plantain peel) is useful in prevention and control of numerous health problems in Ayurveda, an ancient system of medicine. The anti-ulcer activity and effects of varied dosages of its methanolic extract on gastrointestinal motility were investigated in this study. Fifteen (15) Wistar rats of 150 and 200 g were deprived of food for 24 hours; then divided into five groups (Groups I through V) of three rats each; while group I (control) received 5ml/kg of distilled water, groups II, III and IV received 100 mg/kg of indomethacin (ulceric), 5mg/kg of omeprazole (after inducing ulcer), and 200 mg/kg of M. paradisiaca respectively. After inducing ulcers with indomethacin, Group V animals were fed (orally) with 400mg/kg of extract. Oral administration of ethanol injured the mucosal lining, resulting in gastrointestinal bleeding with ulcer indexes of 13.30, 10.57, 10.62, and 9.01 in groups II to V respectively, after some time of administration of test substances. In additi...
Analgesic and anti-inflammatory properties of leaf extract
Journal of Ethnopharmacology, 2005
The aqueous and methanol extracts from the dry bulbils of Dioscorea bulbifera L. var sativa (Dioscoreaceae)-evaluated orally at the doses of 300 and 600 mg/kg against pain induced by acetic acid, formalin, pressure and against inflammation induced by carrageenan, histamine, serotonin and formalin in mice and rats, showed a dose dependant inhibition of pain and inflammation with a maximum effect of 56.38%, 73.06% and 42.79% produced by the aqueous extract, respectively on pain induced by acetic acid, formalin and pressure while the methanol extract at the same dose respectively inhibited these models of pain by 62.70%, 84.54% and 47.70%. The oral administration of aqueous and methanol extracts caused significant anti-inflammatory activity on paw oedema induced by histamine, serotonin and formalin. The present results show that the bulbils of Dioscorea bulbifera var sativa possess potent analgesic and anti-inflammatory activities. These activities may results from the inhibition of inflammatory mediators such as histamine, serotonin and prostaglandins. Thus, the analgesic activity of the bulbils of Dioscorea bulbifera may be at least partially linked to its anti-inflammatory activity.
Objectives: Abelmoschus esculentus is an important medicinal plant for its traditional and folkloric uses against different types of diseases such as headaches, arthritis, abdominal pain, inflammation etc. It also has been reported that root of the Abelmoschus esculentus possesses good CNS depressant activity along with high analgesic activity in Swiss albino mice. So present study investigated the anti-inflammatory, analgesic and anti-nociceptive activities of methanolic and water extracts of the peel of the Abelmoschus esculentus fruits. Methods and Materials: Anti-inflammatory study was done by carrageenan induced inflammation test for anti-inflammation activities while acetic acid induced writhing test and formalin induced pain test was done for analgesic activities and anti-nociceptive activities respectively in Swiss albino mice. Results: The experimental activities of the methanolic and water extracts of the peels of Abelmoschus esculentus fruits showed statistically significant anti-inflammatory activity (50.87% and 40.87%) in carrageenan induced inflammation test, analgesic activity (77.59% and 68.04%) in acetic acid induced writhing test and anti-nociceptive activity (70.06% and 63.40%) in formalin induced pain test in Swiss albino mice for 200mg. Conclusion: Based on the results of the present study, we conclude that the methanolic and water extracts of peels possess strong anti-inflammatory, analgesic and anti-nociceptive activities. However, further studies are necessary to scrutinize underlying mechanisms of anti-inflammatory, analgesic and anti-nociceptive effects and to isolate the active compounds responsible for these pharmacological activities.
Musa paradisiaca Linn. belonging to the family Musaceae is a common medicinal plants use in herbal medicine for the treatment of diseases like diabetics, hypertension and ulcer. This study evaluated the antiulcerogenic potentials of aqueous extract of fermented unripe M. paradisiaca fruits using acetic acid, aspirin, ethanol, indomethacin and pyloric ligation-induced ulcer models at the doses of 400 and 800 mg/kg body weight. Omeprazole at 5 mg/kg was used as a standard reference drug. The result of the acute toxicity test showed that up to 5,000 mg/kg body weight of the extract did not cause any mortality of the wistar rats. The different doses of the extract and the reference drug significantly (p<0.05) decreased all the ulcer parameters (ulcer score and ulcer index) in a dose dependent manner in all the ulcer models. The degree of ulcer index is in the order: Pyloric-ligation (11.33±0.12) < Indomethacin (12.03±0.14) < Acetic acid (12.17±0.23) < Aspirin (13.20±0.10) < Ethanol (15.60±0.40). Similarly, the percentage gastro-protective activity increased from 0% in the negative control up to 23.56% at the dose of 800mg/kg body weight of the extract. The degree of percentage gastro-protection is in the order: Pyloric-ligation (7.93%) < Indomethacin (10.51%) < Acetic acid (13.51%) < Ethanol (22.19%) < Aspirin (23.56%). The enhanced cessation of gastric erosions could be attributed to the synergistic role of probiotics and phytochemicals in the plant extract. In conclusion, fermented unripe M. paradisiaca fruit extract is a good candidate for screening of new antiulcer drugs.
This study investigated the ulcer healing potential of unripe Musa paradisiaca fruit on aspirin induced gastric ulcer. Twenty five (25) adult wistar rats were divided into five groups (A, B, C, D and E) of five rats each. Group A was administered with 2ml/kg distilled water orally (normal control), Group B was administered with 300mg/kg b.w aspirin orally (negative control) Groups C-E were administered with 300mg/kg aspirin orally prior to treatment with 100, 500 and 1000mg/kg b.w orally respectively. The animals were sacrificed by cervical dislocation and ulcer index was determined on harvested stomach tissue. Oral administration of aspirin caused a significantly high ulcer index (1.53±0.46). However, treatment with extract of Musa paradisiaca fruit significantly reduced the ulcer index in a dose dependent manner in which 0.44±0.02 was recorded on 1000mg/kg of the extract. The observation was in concordance with that of the percentage ulcer inhibitory result which was also found to be dose dependent with 71.24% inhibition recorded on administration of 1000mg/kg of the extract. From the findings, it can be deduced that unripe Musa paradisiaca fruit have ulcer healing potential and should be recommended as an ideal diet for individuals on high risk category for gastric ulcer resulting from NSAID treatment.
Wound healing and antioxidant capacity of Musa paradisiaca Linn. peel extracts
Journal of Pharmacy & Pharmacognosy Research, 2016
Resumen Context: Musa paradisiaca has several biological activities within them wound healing, hypoglycemic, hepatoprotective, antimicrobial, antioxidant, among others. However, these properties in peel have been poorly explored. Aims: Evaluate the wound healing activity induced by an incision wound model using methanolic, hexanoic and chloroformic extracts from M. paradisiaca peel. Methods: Dehydrated M. paradisíaca peel was mixed with methanol, hexane, and chloroform. The presence of bioactive substances of the M. paradisiaca peel extracts was carried out by the Trease and Evans methods. Antioxidant capacity was evaluated by the 2,2-diphenyl-2-picrylhydrazyl (DPPH) method. Acute toxicity was realized according to up and down OECD procedure in BALB/c mice. Wound healing activity was evaluated in male Wistar rats. Histological analyses of tissues were made by microscopy using staining methods of hematoxylin and eosin and Masson-trichrome. Results: Treated groups with methanolic and hexanoic extracts of M. paradisiaca peel showed better wound healing activity in comparison with the group treated with chloroformic extract, with an inhibition of DPPH radical bleaching of 89-90%. It may be due to the presence of alkaloids, tannins, saponins and phenols as principal constituents by conferring antioxidant capacity. The extract did not induce any toxicity. Conclusions: The findings showed the wound healing and antioxidant capacity of M. paradisiaca peel extract. It was observed that depending on the extraction solvent; there is a variation in the antioxidant capacity that also affects the effectiveness of the restoration of tissue, suggesting that the antioxidant capacity could play a major role in the process of wound healing.