Prevalence, Pattern and Association of Pruritus with Quality of Life in Chronic Kidney Disease Patients Attending Kidney Care Centre, Ondo City, Southwest Nigeria (original) (raw)
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Jurnal Aisyah : Jurnal Ilmu Kesehatan
Chronic Kidney Disease (CKD) is characterized by progressive loss of kidney function over time due to kidney damage or reduced glomerular filtration rate (GFR) <60 mL/min/173m 2 for >3 months. The increased levels of urea in patients with chronic kidney failure can cause pruritus known as uremic pruritus or chronic kidney disease associated pruritus (CKD-ap). The research method that will be used is PRISMA. These scoping reviews will use a systematic approach and selection process. Library sources were traced from the Proquest, PubMed, Scopus and Google Scholar databases. This scoping review examines the associated factors with pruritus in patients undergoing dialysis. Factors related to uremic pruritus, namely based on analysis through scoping reviews that have been carried out on 8 articles, it was found that the most widely used study design was cross-sectional, the most widely used type of dealisis is hemodialysis with the number of articles is 3 articles and the number of patients that is male 505 samples (60.4%) and women 331 samples (39.6%) with the Total is 836 samples. Factors associated with uremic pruritus are gender, age, dialysis dose, duration of dialysis, urea/urea, C-Reactive Protein (CRP), and parathyroid hormone (PTH).The conclusion is that the factor that most dominant factor affecting pruritus is the factor of laboratory results, which is a factor that can be modified Keyword: Chronic Kidney Disease Dialysis Itching Uremic Patients Causes Pruritus This open access article is under the CC-BY-SA license.
Pruritus and long-term hemodialysis among patients with chronic renal failure
International Journal of Public Health Science (IJPHS)
Patients with hypertension and diabetes are at risk of developing chronic kidney failure. A common occurrence in patients with chronic kidney disease is pruritus. Pruritus can affect all parts of the body, which can have an emotional impact on the patient, affect the quality of sleep and mood of the patient, and cause discomfort. The study's goal was to determine whether there was a long-term link between hemodialysis and the onset of pruritus among patients with chronic renal failure who were receiving hemodialysis. Quantitative research with the cross-sectional method A total of 45 patients are in the RSI Sultan Agung Semarang Hemodialisa Unit, Central Java, Indonesia. The instrument in this study was the 5D pruritus scale. Data analysis was done using SPSS version 24. The Spearman rank test was conducted to test the relationship between two variables of the study, namely the duration of hemodialysis and the occurrence of pruritus. The study was conducted in April–June 2022, a...
Therapeutic Apheresis and Dialysis, 2019
CKD-associated pruritus is one of the common symptoms in patients undergoing dialysis, thus contributing to the diminished and compromised quality of life. This study aimed to explore the association between the CKD-associated pruritus on quality of life of patients undergoing hemodialysis in Malaysia. A cross-sectional multicenter study, carried out from February to September 2017 at tertiary care settings in Kuala Lumpur, Malaysia. Patients aged 18 years and above, undergoing hemodialysis, understanding Malay language and willing to participate were included. The CKD-associated pruritus was assessed by using Malay 5D-itch scale and Malay FANLTC questionaiare. To determine the factors associated with pruritus and quality of life, multivariate logistic regression analysis was used having P value < 0.05 as statistically significant. Among n = 334 recruited patients with a response rate of 100%, 59.6% were males and total of 61.3% were having CKD-associated pruritus.
Medicine, 2019
Chronic kidney disease (CKD)-associated pruritus is one of the most common symptoms found in patients who undergo dialysis for CKD, leading to a compromised quality of life. This study aimed to investigate the association between CKD-associated pruritus and the quality of life in patients undergoing hemodialysis in Pakistan. A cross-sectional multicenter study was carried out from July 2016 to April 2017 in 2 tertiary care hospitals in Pakistan. Patients aged 18 years and above of both genders, undergoing hemodialysis, understood the Urdu language, and were willing to participate; were included. Of 354 recruited patients with a response rate of 100%, majority (66.1%) of the patients were males. The median (intra-quartile range [IQR]) age of patients was 42.0 [34.0-50.0] years. The prevalence of pruritus was 74%. The median [IQR] score for pruritus was 10.0 (out of possible 25) [8.0-12.0]. Multivariate linear regression revealed a statistically significant association between CKDassociated pruritus with age of patients (b = 0.031; 95% confidence interval [CI] = 0.002-0.061; P = .038), duration of CKD (b = À 0.013; 95% CI = À0.023-À0.003; P = .014) and quality of life (b= À0.949; 95% CI = À1.450; À0.449). The median [IQR] score for health-related quality of life was 52.00 [43.00-58.00]. Prevalence of CKD-associated pruritus was reported to be 74% and it negatively affected the patient's quality of life. Patients with moderate to severe CKD-associated pruritus have poor quality of life. With an increase in intensity of pruritus, the QOL score decreased among the patients undergoing hemodialysis. Abbreviations: CI = confidence interval, CKD = chronic kidney disease, FANLTC = functional assessment for non-life-threatening conditions, IQR = intra-quartile range, KMO = Kaiser-Meyer-Olkin.
Prevalence and severity of pruritus amongst patients with chronic kidney disease
IP Indian Journal of Clinical and Experimental Dermatology, 2020
Introduction: Skin problems are common and diverse in patients with chronic kidney disease (CKD). Pruritus is a highly prevalent condition in patients with chronic kidney disease. It is associated with poor sleep quality, anxiety and depression which may contribute to reduction in quality of life. Objective: To study the prevalence and severity of pruritus among patients with chronic kidney disease. Materials and Methods: An observational study was conducted in 77 consecutive chronic kidney disease patients receiving maintenance hemodialysis for more than 3 months at Manik hospital, Aurangabad, Maharashtra, India were studied during January 2015 to December 2015. Results: Out of 77 patients, 51 (66.23%) of males and 26 (23.67%) of females were examined. The mean age was 51.17 years. Xerosis was the commonest manifestation (87.01%), followed by pruritus (57.14%). Mild pruritus was reported in 59.09% patients whereas severe pruritus was noted in 22.27% patients. High urea, phosphate and ALP levels were noted in severe pruritus group, but difference not statistically significant. 32 patients with pruritus on maintenance HD were followed over next 6 months. Out of 32 patients followed, 37.5% had no change in pruritus. Pruritus improved in 28.12%, while it actually worsened in 34.37% patients. Conclusion: In this study, 57.14% of patients with chronic kidney disease experience pruritus. Gender, age, presence of DM, duration of dialysis was not statistically significant between pruritus and non-pruritus group. Also hematocrit was similar in pruritus and non-pruritus groups. There was no significant difference in calcium, phosphorus and alkaline phosphatase levels in pruritus and non-pruritus groups.
Pars of Jahrom University of Medical Sciences, 2013
Thi study aimed to determine the status of pruritus and its relation to dialysis adequacy and laboratory factors among hemodialysis patients in Shiraz dialysis centers so that appropriate interventions could be planned for promotion of the life quality. Materials and Methods: This is a cross-sectional study on the data collected from 141 patients selected by convenient sampling. We used a questionnaire, interview, and lab test for data collection. Data were analyzed using SPSS 11.5 software and appropriate tests. A p value=0.05 was considered as the significance level. Results: The mean age of our patients was 53±16 years, (82.3% were married), and 53.2% of them were male. Of these patients, 39.7% had pruritus and most of them (48.1%) reported they had pruritus in different times of the day. A significant correlation was found between dialysis adequacy and pruritus (p=0.029), and the correlation of pruritus and high sensitive-C-reactive protein (hs-CRP) was significantly positive (p=0.009). Conclusion: Pruritus is a common problem in haemodialysis patients and is significantly associated with dialysis adequacy and hs-CRP. The level of their quality of life could be enhanced by appropriate interventions.
International journal of health sciences
Background and Aim: Chronic kidney disease-associated pruritus (CKD-aP), commonly known as uremic pruritus is a frequent and inconvenient disease for patients undergoing hemodialysis. The purpose of the present investigation was to determine the association of CKD-associated pruritus with quality of life in patients undergoing hemodialysis presented to the nephrology division of Khyber Teaching Hospital Peshawar. Patients and Methods: This cross-sectional study was conducted on 227 CKD-associated pruritus patients investigated in the Nephrology Division of Khyber Teaching Hospital Peshawar from March 2022 to February 2023. Patients of either gender (>18 years) undergoing hemodialysis were enrolled. Demographic details, dialysis duration, duration of disease, and various comorbidities conditions were recorded based on a pre-designed questionnaire. Results: Out of 227 patients, there were 142 (62.6%) male and 85 (37.4%) female. The overall mean age was 40.82±6.82 years. The inciden...
Prevalence, patient burden and physicians’ perception of pruritus in hemodialysis patients
Nephrology Dialysis Transplantation, 2023
Background. Chronic kidney disease-associated pruritus (CKD-aP) is an underrated symptom in patients with impaired kidney function. The present study assessed the prevalence, impact on quality of life (QoL) and risk factors for CKD-aP in a contemporary national cohort of patients on hemodialysis. In addition, we evaluated attending physicians' awareness and approach to therapy. Methods. Validated patient's and physician's questionnaires on pruritus severity and QoL were used in combination with information obtained by the Austrian Dialysis and Transplant Registry. Results. The prevalence of mild, moderate and severe pruritus in 962 observed patients was 34.4, 11.4, and 4.3%. Physicians' estimated prevalence values were 54.0 (42.6-65.4), 14.4 (11.3-17.6) and 6.3% (4.9-8.3), respectively. The estimated national prevalence estimate extrapolated from the observed patients was 45.0 (95% CI 39.5-51.2) for any, 13.9 (10.6-17.2) for moderate and 4.2% (2.1-6.2) for severe CKD-aP. CKD-aP severity was significantly associated with impaired QoL. Risk factors for moderate to severe pruritus were higher Creactive protein (OR 1.61; 95% CI 1.07-2.43) and parathyroid hormone values (OR 1.50; 95% CI 1.00-2.27). Therapy of CKD-aP included changes in the dialysis regime, topical treatments, antihistamines, gabapentin and pregabalin, and phototherapy in a majority of centers. Conclusions. While the overall prevalence of CKD-aP in our study is similar to previously published literature, the prevalence of moderate to severe pruritus is lower. CKD-aP was associated with reduced QoL and raised markers of inflammation and parathyroid hormone. The high awareness of CKD-aP in Austrian nephrologists may explain the lower prevalence of more severe pruritus. KEY LEARNING POINTS What was known:-While the overall prevalence of CKD-aP in our study is similar to previously published literature, the prevalence of moderate to severe pruritus is lower This study adds:-Awareness of chronic kidney disease-associated pruritus (CKD-aP) is high in Austrian nephrologists compared to previously published literature Potential impact:-High awareness and a multimodal treatment approach might explain the lower prevalence of moderate to severe pruritus in this study
2009
Lichen Simplex Chronicus (LSC) is a skin disorder affecting patient's psychosocial and functional status. Pruritus is a diagnostic hallmark for LSC. It is the reason for sleep disturbances, anxiety and depression. Therefore, a clinical investigation of pruritus alongside with a study of their self-reported health status is a necessary precondition for successful therapeutic results. The aim of the study is to assess the impact of pruritus on quality of life (QoL) of LSC patients'. MATERIALS AND METHODS: The presented study includes 190 outpatients diagnosed with LSC. Demographic data and disease-related characteristics were collected. Measurement tools, for assessing pruritus severity and sleep disturbance were visual analogue scale (VAS), and verbal rating scale (VRS).For the evaluation of QoL Dermatological Life Quality Index (DLQI) questionnaire was applied. RESULTS AND DISCUSSION: Main complains of patients were pruritus and sleep disturbance. 40% reported having low intensity pruritus (mean VAS 1.90), 36.84% moderate pruritus (mean VAS 5.12), and 23.15% severe pruritus (mean VAS 8.57). Results from sleep disturbance were: 4.73% reported currently having no sleep disturbance (mean VAS 0.18), 43.15 % reported having mild sleep disturbance; 47.36% have moderate sleep disturbance (mean VAS 5.46), and 4.73% severe sleep disturbance (mean VAS 8.93). The total DLQI score reported by the LSC-patients is 8.58±3.348. Patients scores were significantly high for Q1 (symptoms), Q9 (sexual difficulties) and Q10 (treatment) (p<0=001). CONCLUSION: All the reported and analyzed results indicate that pruritus is a major symptom in LSC and has a negative impact on all the QoL-domains for every patient (p<0.001). Consequently, pruritus moderately affects the QoL of the patients. This is the first study in our country, which aims to measure the impact of pruritus on QoL of LSH patients'.