Individual differences in the activity of the hypothalamus-pituitary-adrenocortical system after stressors: Use of psychogenetically selected rat lines as a … (original) (raw)

This chapter explores individual differences in stress responses, focusing on the hypothalamus-pituitary-adrenocortical (HPA) axis activity in psychogenetically selected rat strains, particularly Wistar-derived Roman High-Avoidance (RHA) and Low-Avoidance (RLA) rats. By examining physiological and behavioral mechanisms during stress exposure, the chapter highlights the complex neuroendocrine processes involved, showing how different rat lines exhibit variations in their metabolic and behavioral responses to stress. Early phenotypic differences during the neonatal period are also addressed, emphasizing the relevance of these findings to understanding stress adaptation and its implications for broader neuroendocrine research.