Inherited thrombophilia: Part 1 (original) (raw)

Inherited thrombophilia refers to a genetic predisposition to venous thromboembolic events, stemming from specific deficiencies in anticoagulants such as antithrombin, protein C, and protein S. Although the concept began gaining traction in the late 20th century, significant advancements in understanding the genetic basis and the role of coagulation pathways have been made. This review highlights major hereditary factors contributing to thrombophilia and underscores the importance of recognizing familial patterns in diagnosing and managing thrombotic risks.