Vitamin D Level in Children with Type 1 Diabetes Mellitus in Duhok City / Kurdistan, Iraq (original) (raw)
Related papers
Serum Vitamin D Level in Children with Type 1 diabetes mellitus in Duhok city, Iraq
Science Journal of University of Zakho, 2019
Type 1 Diabetes Mellitus is an autoimmune disorder that occurs in the Β-cells of pancreatic islets. Vitamin D is essential in maintaining the bone health. It has proven that Vitamin D has an autoimmune disorder including T1DM. Hence, the aim is to detect the prevalence of vitamin D deficiency among children with T1DM. A case control study conducted in Duhok, North of Iraq between 15 th of February and 15 th of August 2016. 100 enrolled participants aged from 5 to 15 years of both genders were divided in to two groups. Fifty of them had T1DM and 50 children who were healthy and non-diabetic. All participants were studied in terms of age, gender, duration of diabetes, glycemic control (HbA1c) and Body Mass index. Samples of blood were taken to measure serum Vitamin D and HbA1c levels. Mean serum Vitamin D level in diabetic group was 6.068 ±2.45 ng/mL while in the control group it was 21.101 ±9.23 ng/mL. Vitamin D were lower in the diabetic patients than controls (P= 0.01). Vitamin D level was indirectly correlated with duration of diabetes (P=0.01). Level of Vitamin D was decreased with increasing HbA1C (P=0.01). Level of Vitamin D was not significantly related to body mass index. Vitamin D level is not significantly related to body mass index.
High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children
Acta Diabetologica, 2009
Epidemiological studies suggest a link between vitamin D deficiency in early life and the later onset of type 1 diabetes. The aim of this matched case-control study was to find the association between vitamin D and T1DM then to study the difference in the level of vitamin D in T1DM and healthy subjects, and to determine the associated environmental risk factors in young Qatari population. The study was carried out among T1DM children and healthy subjects below 16 years at the pediatric endocrinology outpatient clinics of the Hamad General Hospital and the Primary Health care Clinics (PHCs). The survey was conducted over a period from 6 August to 25 December 2007. The subjects were Qatari nationals male and female aged below 16 years. The study is based on matching by age, gender and ethnicity of 170 cases with those of 170 controls. Faceto-face interviews were based on a questionnaire that included variables such as socio-demographic information, assessment of non-dietary covariates, assessment of dietary intake, vitamin D intake, type of feeding, clinical manifestations and laboratory investigations. Their health status was assessed by medical conditions, family history, BMI, past or present clinical manifestations, 25 (OH)D, Calcium, alkaline phosphatase, phosphorus, HbA1C, PTH, Mg and creatinine analysis. The study revealed that vitamin D deficiency was considerably higher in T1DM children (90.6%) compared to non-diabetic children (85.3%). There was a significant difference found in the mean value of vitamin D between T1DM and non-diabetic children (P = 0.009). There were statistically significant differences between type 1 diabetic and healthy subjects with respect to the occupation of parents (P \ 0.001) and consanguinity rate (P \ 0.047). Family history of vitamin D deficiency was considerably higher among T1DM children (35.3%) with a significant difference between diabetic and nondiabetic children (22.9) (P \ 0.012). Vitamin D supplement with breast milk was very poor in diabetic children (37.4%) compared to non-diabetic children (47.7%). Majority of the studied subjects were breast-fed children (95.1% of diabetic children and 97.2% of healthy children). Multivariate logistic regression analysis revealed that fathers and mothers occupation, family history of DM, physical activity, low duration of time under sun light, breast feeding less than 6 months and low vitamin D level were considered as the main factors associated with the T1DM. In conclusion, the present study revealed that vitamin D deficiency was higher in T1DM children compared to non-diabetic. Moreover, vitamin D deficiency was common in Qatari young population. Vitamin D intake was very poor in children and it shows that supplementing infants with vitamin D might be a safe and effective strategy for reducing the risk of T1DM.
Association between Vitamin D Status and Type 1 Diabetes Mellitus in Saudi Adolescents
Background: Nowadays, the deficiency of vitamin D (VD) is a health problem worldwide, that affects many people including adolescents who have type 1 diabetes mellitus (T1DM). However, the role of VD in autoimmune diseases such as T1DM has been a recent interest. Aim: This study was designed to assess the VD deficiency prevalence in Saudi adolescents with or without T1DM. Methods: In this case-control study, 49 T1DM and 49 control (non-DM) (N=98), age and gender-matched were enrolled. The study was carried out from May to September 2017 at King Abdulaziz University Hospital (KAUH). After obtaining the consent form, the blood samples were withdrawn to determine fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) in blood and VD (25OHD) in serum. Statistical analysis was made by SPSS version 22. Results: Data showed that 25OHD levels were significantly lower in adolescents with T1DM compared to the controls (49.5 ± 26.9 nmol/L vs 67.96 ± 30.03 nmol/L). In the T1DM adolescents, VD was deficient in 44.9%, insufficient in 36.7%, and
Serum Vitamin D Level in Children with and without Type 1 Diabetes Mellitus
Journal of Diabetes & Metabolism, 2016
For years, vitamin D has been associated to many immune disorders. Several studies have shown association between low serum 25 OH vitamin D and type 1 diabetes mellitus (T1DM). Objective: To compare 25 hydroxy vitamin D (25 OHD) level in T1DM patients to non-diabetic children hospitalized or seen in emergency for other diseases at the same period. Methods: It was a case-control study including 29 patients with T1DM and 28 non-diabetic control children. They were comparable in age, gender, weight, length, BMI and season of blood sampling. Epidemiological and clinical data were collected and 25OHD serum level was measured with a radioimmunoassay kit. Results: 25OHD level was significantly lower in diabetic patients (mean: 19.62 ng/ml, range 15-26 ng/ml) than in control patients (24.64 ng/ml, 20-28 ng/ml), p=0.00. All participants (T1DM patients and controls) had inadequate levels of vitamin D. Conclusion: Children with T1DM have lower vitamin D levels than control group.
Background: Vitamin D inadequacy constitutes an increasingly recognized comorbidity among Saudi populations. There were limited data about its prevalence in Saudi children with type 1 diabetes mellitus (T1DM). Aim: To evaluate the prevalence of vitamin D deficiency among Saudi children and adolescents with T1DM in Albaha region, southwestern of Saudi Arabia. Methods: A cross-sectional study was conducted on 117 Saudi children and adolescents with T1DM. These patients were recruited from Albaha diabetic center, Saudi Arabia. The range of age of the participants was 1 –18 years.. All participants were subjected to history taking including, age, gender, duration of diabetes, clinical presentation at the onset of diabetes. Measurement of serum 25 hydroxy vitamin D was done in all participants. Results: There were 117 Saudi children and adolescent with T1DM, 52 (44.4%) were boys, and 65 (55.6%) were girls with a mean age 8.8 ± 3.4 and 9.2 ± 3.9 for boys and girls respectively (p=0.52). The mean serum 25-hydroxy vitamin D levels among them was 17.1± 10.1 ng/ml and the prevalence of vitamin D inadequacy was 88.9% (59.9% of subjects had vitamin D deficiency and 29 % had vi tamin D insufficiency) and 11.1% had sufficient levels of 25-hydroxy vitamin D. There was a significant difference in vitamin D level among different groups of vitamin D level (p˂ 0.001). The prevalence of Vitamin D deficiency was greater in the girls with 34.2%, as compared to 25.6% among boys. Vitamin D deficiency was more common among children in the range of age 1-10 years (52.1% vs 36.8%). In vitamin D deficient group, the mean levels of vitamin D were significantly lower in patients presented with DKA as compared to those presented with hyperglycemic symptoms (p= 0.016). Conclusion: Vitamin D deficiency is common in Saudi children and adolescent with T1DM in Albaha region. This is more common in girls and in the younger age groups. Therefore, screening for vitamin D deficiency, creating awareness to increase sunlight exposure, increase the fortification of food products with vitamin D and vitamin D supplementation for these patients should be warranted to prevent future morbidity.
Pediatrics Sciences Journal, 2022
Background: The Type 1 Diabetes Melitus (T1DM) is a disease which is occurred because of autoimmune destruction in pancreas islet (insulin-producing ß cells). A Failure mechanism of immunoregulator causes inflammatory process in the islets and continue to damage the pancreatic β cell. Vitamin D deficiency may increase the risk of autoimmune diseases including type 1 diabetes mellitus. The aim of this study was to know the level of vitamin D in type 1 diabetes mellitus. Methods: An observational analytic cross-sectional design was conducted among 40 T1DM subjects and 40 healthy controls aged between 10-18-year-old. They were not having local or systemic infection, nor liver and kidney disorders. Vitamin D levels were measured by the ELISA method (ng/ ml). Subjects' data were collected and processed by 2007 Microsoft Excel software, then analyzed with SPSS version 16.0 for Windows. Results: Most of respondents in T1DM group were female (57.5%) and 15.94±1.00 years old for average age but not statistically significant compared with control group (p>0.05). There was a significant different of the mean level of vitamin D3 in the T1DM group (10.41 + 2,20 ng/ml) compared with control group (18.41 + 1.41 ng/ml) (p<0,05). Conclusion: The level of vitamin D (25 (OH) D3) in the T1 DM group were significantly lower compared to the control group
Assessment of Vitamin D status in Type 1 Diabetes Mellitus in pediatric age group
Background: Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia. Type-1-Diabetes Mellitus (TIDM) results from autoimmune destruction of beta cells leading to insulin deficiency. Vitamin D deficiency (VDD) may have a role in the pathogenesis and development of T1DM by regulating immune mechanism. Materials and Methods: The aim of this study is to assess and evaluate the connection between fasting blood sugar (FBS), post prandial blood sugar (PPBS), glycated hemoglobin (HbAlc) and Vitamin D levels in children with TlDM. This study included 50 healthy controls and 50 previously diagnosed TlDM cases of both sex in the age group of 6-l5 years. 25 hydroxy Vitamin D3 (25-OH Vit D3) level was estimated by Enzyme Linked Fluorescent Assay (ELFA), FBS, PPBS by GOD-POD method, HbAlc levels by Ion Exchange Resin method. Results: Results showed a decreased 25-OH Vit D3 and an increased FBS, PPBS and HbAlc levels which are highly significant (p<0.00l) in TlDM cases than healthy controls. A highly significant negative correlation was observed between FBS, PPBS, HbAlc and 25-OH Vit D3 (P<0.00l) in TlDM cases. Conclusion: VDD has consistently been shown to be prevalent in children with TIDM, which plays an important role in its pathogenesis. Vitamin D, an immunomodulator is an important factor in glycemic control with subsequent prevention of T1DM and its further complications.
Influence of Supplementary Vitamin D on the Prognostic Pathway of Type1 Diabetes Among Children
Biomedical and Pharmacology Journal, 2021
Diabetes is one of the commonest chronic diseases worldwide. Vitamin D deficiency showed to be increasing, and have a potential role in autoimmune diseases among which in type 1 diabetes. The aim The aim of the study was to assess the impact of oral vitamin D supplementation on blood glucose (HbA1C) in T1DM patients and to find out the role of vitamin D as a biomarker for follow of T1DM patients compared to HbA1C. Subjects and methods: A randomized interventional clinical study was designed. The study enrolled 60 children patients with T1DM. Only 45 children continued to the end of study. Initial (pre-intake) assessment included history taking, clinical examination, and measurement of serum 25-OH vitamin D3 and serum HbA1C. These children received oral vitamin D supplements for 3 months then post-intake assessment were done again. Results: The study showed that serum vitamin D was deficient among Egyptian children and adolescents with T1DM (mean 11.4±3.4 ng/ml). , 53.33% of the pati...
Vitamin D status in diabetic Egyptian children and adolescents: a case–control study
Italian Journal of Pediatrics, 2013
Background: Recently, studies suggesting that vitamin D deficiency correlates with the severity and frequency of Type 1 (insulin-dependent) diabetes mellitus (T1DM) and that vitamin D supplementation reduces the risk of developing T1DM have been reported. Objective: In this study, we aimed to assess vitamin D status in Egyptian children and adolescents with T1DM.
Low levels of vitamin D in North Indian children with newly diagnosed type 1 diabetes
Pediatric Diabetes, 2009
To find out whether vitamin D levels are lower in children with newly diagnosed type 1 diabetes (T1D) as compared to non-diabetic subjects. Plasma levels of vitamin D (25-OHD) were measured by high performance liquid chromatography (HPLC) in 50 children aged between 6 and 12 yr within a week of diagnosis of T1D, and in 50 healthy children. The mean levels of vitamin D were significantly lower in patients as compared to their controls [20.02 +/- 10.63 ng/mL (50.05 +/- 26.57 mmol/L) vs. 26.16 +/- 12.28 ng/mL (65.4 +/- 30.7 mmol/L), p-value 0.009]. Twenty-nine (58%) children in the study group were vitamin D deficient (25-OHD level &amp;amp;amp;lt; 20 ng/mL or &amp;amp;amp;lt; 50 mmol/L) as compared to only 16 (32%) in the control group. Overall, 43 (86%) diabetic and 38 (76%) healthy children were either vitamin D deficient or insufficient. These results suggest that vitamin D levels are low at the onset of T1D, and they strongly support the need for further clinical studies to prospectively evaluate the effect of vitamin D supplementation on T1D rates in this patient population.