Genetics of complex diseases: knowing gene polymorphisms do matter (original) (raw)
2013, Cadernos De Saude Publica
AI-generated Abstract
The complexities of genetic contributions to diseases demand a deeper understanding of gene-environment interactions. Advances since the completion of the human genome project have enabled genome-wide association studies (GWAS) that inform about genetic polymorphisms linked to complex diseases. Effective case-control designs and clearly defined phenotypes are critical for uncovering the specific genotype-phenotype associations, though challenges persist in defining phenotypes and validating findings.
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