Salivary gland tumors: a 15-year experience of a universıty hospital in Turkey (original) (raw)
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Primary Salivary Gland Tumors- A two years study at Nobel Medical College
Nepalese medical journal, 2019
Salivary gland tumors are a heterogenous group of neoplasms that are relatively rare but represent a wide variety of both benign and malignant histopathologic subtypes. The global incidence is 1 in 100,000 individuals and comprises less than 3% of all head and neck neoplasms. 1 The frequency of benign tumors of salivary glands is higher in females whereas malignant tumors occur more frequently in males. 2,3 The most common benign tumor is pleomorphic adenoma followed by warthin's tumor, whereas most common malignant tumor is mucoepidermoid carcinoma followed by adenoid cystic carcinoma. 2-5 Benign tumors of salivary glands are most commonly seen in 30-70 years with a mean age of 45 years and peak incidence of malignant tumor in seen in 6th and 7 th decades. 6,7 Conclusions: Benign salivary tumors are more common than malignant tumors with the most common occurrence in parotid glands. Pleomorphic adenoma is the most common benign tumor whereas; mucoepidermoid carcinoma is the most common malignant tumor in patients visiting Nobel medical college.
Retrospective study of 124 cases of salivary gland tumors and literature review
Journal of Clinical and Experimental Dentistry
Background: Salivary gland tumors are a rare and morphologically diverse group of lesions and their frequency is still unknown in several parts of the world. The knowledge of its population characteristics contributes to a better understanding of its etiopathogenesis. Objectives: This study investigated the frequency of salivary gland tumors in a region of southern Brazil and compared these data in a literature review. Material and Methods: A retrospective study was conducted of salivary gland tumors diagnosed at two pathology centers from 1995 to 2016. Patient age and gender, tumor site and frequency, histopathological diagnosis, and symptomatology were evaluated. Chi-squared tests were used to assess the associations between variables. To compare our data, we also conducted a literature review of publications in the PubMed and LILACS databases of retrospective studies of salivary gland tumors. Results: A total of 124 salivary gland tumor cases was identified, 81 (65.3%) of which were classified as benign and 43 (34.6%) as malignant. Most tumors occurred in the parotid gland (57.2%). Pleomorphic adenoma was the most common tumor (59.6%), followed by adenocarcinoma not otherwise specified (8.8%). The tumors occurred more often in women (54.8%) than in men (45.2%). Malignant tumors were associated with pain in 31.4% of cases (p <0.05). The literature review included 35 articles from different countries. Women were most affected, with a mean age of 41.7 years. The most common benign tumor was pleomorphic adenoma (48.2%) and the most common malignant tumor was mucoepidermoid carcinoma (8.7%). Conclusions: The results of the present study showed that salivary gland tumors are rare. The parotid gland is the most common location and pleomorphic adenoma are the most frequent lesions. The malignant tumors presented as several histological types and the incidence was variable globally.
International Journal of Otorhinolaryngology and Head and Neck Surgery, 2020
Background: Salivary gland tumours constitute 3-4% of all head and neck cancers (mostly benign). These tumours are epithelial (95%) or mesenchymal in origin. Pleomorphic adenoma is the most common benign salivary gland tumour and mucoepidermoid carcinoma (45%) is the most common malignant salivary gland tumour followed by adenoid cystic carcinoma (30%). The parotid, submandibular and the minor salivary glands of palate are commonly involved and the sublingual gland is rarely affected.Methods: Hospital based cross sectional study was done in a tertiary care centre during a period of 1 year, which included 21 patients (10 men and 11 women). Patients were analysed according to age, gender, food habits, histopathological type and site of the tumour and treatment strategy.Results: All the cases were from upper Assam province sharing a particular demographic pattern between 19-65 years. Peak incidence in males was fourth decade and females was third decade. Male female ratio was 0.9:1. Ou...
HISTOPATHOLOGICAL SPECTRUM OF SALIVARY GLAND TUMOURS: A HOSPITAL BASED STUDY
Background: Salivary gland tumors are common neoplasms of head and neck region. These tumors are complex andsome of them exhibit great deal of morphologic overlap .The majority of these neoplasms are benign. These tumours can occur in both major and minor salivary glands. 80% of major salivary gland tumoursoccur in the parotid glands, while most minor salivary tumours are located in the palate. As a general rule in clinical practice, the smaller the salivary gland is, the more likely the tumouris malignant. Objective: This study was carried out to study the histopathological spectrum of salivary gland tumors and to know their pattern of distribution. Material and Methods:-This is a two year retrospective study which was conducted in the Post graduate department of pathology Government Medical College Srinagar from January 2015 to December 2016 . Post surgical specimens were studied in detail to know the histological patterns. In each patient, age, sex, site and histopathological diagnosis was seen from record section of the department. The histological diagnosis of each individual tumor was based on the 2005 WHO classification of salivary gland tumors. Results:- During two year ( from January 2015 to December 2016), 100 cases of salivary gland tumors were diagnosed with peak incidence in third to fourth decade (48%).Among these, 63(63%) cases were benign and 31(31%) cases were malignant. The commonest site was parotid gland (68%) followed by submandibular glands(19%) and minor salivary gland tumors were 13%. Among benign tumours of salivary glands pleomorphic adenoma (42%) was most common followed by Warthintumour (12%),basal cell adenoma (7%) andMyoepithelioma (2%) and among malignant tumours,Mucoepidermoid carcinoma (46%) was most common followed by Adenoid cystic carcinoma (32.5%), Carcinoma ex pleomorphic adenoma (10.8%), Acinic cell carcinoma and Polymorphous low grade adenocarcinoma each comprising of (5.4%). Conclusion: Histopathological study of salivary gland lesions is the most important method in establishing the final diagnosis and accordingly guides in the specific management.
Salivary Gland Tumors in an Iranian Population: A Retrospective Study of 130 Cases
Journal of Oral and Maxillofacial Surgery, 2007
Tumors of the salivary glands are uncommon, comprising 3% to 10% of head and neck neoplasia. In the absence of epidemiologic studies of these neoplasms in an Iranian population, we conducted a preliminary survey of 130 cases over the last 20 years in Hamedan, Iran. Patients and Methods: The medical records and case notes of all patients with histologically confirmed salivary gland tumors were reviewed retrospectively from February 1984 to March 2003. This review found 89 patients with benign tumors and 41 patients with malignant tumors. The collection of data included gender, age, location, and histopathology of the tumor. Other recorded data included diagnostic procedures, operative reports, complications, additional treatment, and follow-up. Results: We studied 78 females and 52 males with a mean age of 44.9 years. Patients with benign and malignant tumors presented with a mean age of 41.3 and 47 years, respectively. The frequency of benign tumors was 68.4% (n ϭ 89) and 31.6% for malignant tumors (n ϭ 41). Tumors were localized in the parotid gland (63%; n ϭ 82), the submandibular gland (23%; n ϭ 30), and in the minor salivary glands (14%; n ϭ 18). The most common benign tumor was pleomorphic adenoma (65.4%; n ϭ 85). Among malignant tumors, mucoepidermoid carcinoma was the most frequent (11.5%; n ϭ 15), followed by adenocarcinoma (10%; n ϭ 13). Greater than 63% of malignant tumors were treated surgically, and the remaining with combined therapy. Seven patients died over the follow-up period (6 with persistent disease), 5 were lost to follow-up, and 23 remained cancer-free. Conclusion: Between benign and malignant salivary gland tumors, frequency of pleomorphic adenoma and mucoepidermoid carcinoma was in keeping with studies reported previously. In other salivary gland tumors, however, diversity was obvious and showed significant difference, requiring further studies.
Clinicopathological Analysis of Salivary Gland Tumours: An Observational Study
2019
Background: Salivary gland tumour is a comparatively sporadic and morphologically varied collection of pathologic entities. Hence; we histopathologically analyzed the salivary gland tumour in the present study.Materials & methods: The present analysis included histopathologic assessment of salivary gland neoplasms. All the biopsies received in the department were recorded. H and E stained slides were made and were assessed by experienced and certified oral pathologists. Histopathologic diagnosis were recorded in Microsoft excel sheet and were analyzed by SPSS software. Results: Biopsies of a total of 70 salivary gland neoplasms were studies in the present study. Among these, 40 were benign while the remaining 30 were malignant in nature. Total frequency of occurrence of Pleomorphic adenoma, Basal cell adenoma and Warthin’s tumour was 25.6%, 10% and 14.2% respectively. Frequency of occurrence of Adenoid cystic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma, polymorphous low...
Tropical Journal of Pathology and Microbiology, 2018
Background: Salivary gland tumors (SGTs) are rare neoplasm of head and neck region. The salivary gland tumours vary widely in histopathological appearance. Also, epidemiological data of these tumors in various parts of the world are different. And so the study of SGTs for their biology and clinical characteristics can be helpful for a better understanding. Objectives: The objective of this study was to study types and new entities, common site of distribution and histomorphological spectrum of salivary gland tumors (SGTs). Materials and Methods: It was a retrospective followed by prospective study. Pertinent clinical history like age, duration of the lesion, site of the lesion, significant family and personal history, history of associated diseases was recorded. Specimens consisted of incisional biopsies were examined microscopically by the expert pathologist. Details of specimens noted in Performa include dimensions, appearance of external and cut surface and presence of lymph nodes, their size and number. Observations: Total 70 cases of SGTs could be included in the study. Among them 56 (80%) were benign and 14 (20%) were malignant. Parotid is commonest salivary gland involved with 75.71% of all tumors, followed by submandibular with 21.42% and minor salivary glands with 1(1.4%) of salivary gland tumors. among benign tumors Pleomorphic adenoma is most common with 70% of all benign SGTs followed by Warthin tumors (7%). Among malignant tumors commonest is Mucoepidermoid carcinoma with 14.28% of all SGTs. Female preponderance was clearly found in malignan at SGTs. Conclusion: Parotid is most common site for the SGT. And pleomorphic adenoma and the Warthin tumors are the common benign tumors involve parotid gland the most. Among malignant tumors mucoepidermoid carcinoma are the commonest with female preponderance. While other carcinoma like adenoid cystic carcinoma and SCC are also common.
Salivary gland neoplasms: an analysis of 74 cases
Journal of Maxillofacial and Oral Surgery, 2009
cases of salivary gland neoplasms were analyzed retrospectively, of which 44 (60%) were benign and 30 (40%) malignant. 61 % percent of neoplasms were in the parotid gland, 22% in the minor salivary glands including sublingual salivary glands, and 17% in the submandibular glands. The most common benign neoplasm was pleomorphic adenoma (64%), and the most common malignant neoplasm were adenoid cystic carcinoma (17%) and mucoepidermoid carcinoma (23%).We analyze the incidence and distribution of all types of salivary gland neoplasms in our series, and provide data for comparison with other epidemiological studies from different geographical sites and races. Demographic data from these studies help us to a better understanding of the biological and clinical characteristics of the disease. Further epidemiological surveys should be encouraged for better understanding of the disease and to provide early and better treatment of salivary gland neoplasms
Indian Journal of Otolaryngology and Head & Neck Surgery, 2012
The aim of this study was to evaluate the demographic and clinicopathologic data of salivary gland tumors managed at a tertiary referral medical center in Turkey. The data of 510 patients with salivary gland tumors managed during the period of January 1984 to May 2012, were reviewed. Only primary neoplasms derived from salivary glands were included. Out of 510 neoplasms, 352 (69.0 %) were classified as benign and 158 (31.0 %) were classified as malignant. There was a male predominance and male:female ratio was 1.23 (281/229). The most common location was parotid gland (372/510, 72.9 %) followed by minor salivary glands (97/510, 19.0 %) and submandibular gland (40/510, 7.9 %). The malignancy rates were 21.5, 40.0, and 56.7 % in parotid, submandibular, and minor salivary glands locations, respectively. The most common location for minor salivary gland neoplasms was oral cavity (61/97, 62.9 %). Pleomorphic adenoma (PA) was the most common histopathological type (45.3 %) in the whole study group and also among pediatric patients. The most common malignant neoplasms were adenoid cystic carcinoma (39/510, 7.6 %) and mucoepidermoid carcinoma (5.7 %). Salivary gland tumors are more common in men. The malignancy rate is almost three times higher in neoplasms derived from minor glands when compared to parotid gland. PA is the most common histopathological tumor type in all locations and in all age groups.
Incidence & Pattern of Salivary Gland Tumors -A Clinicopathological Study
IOSR Journals , 2019
Background: The salivary glands are one of the few tissues in the body that are subjected to diverse and heterogeneous range of tumors and tumor like conditions. The relative infrequency of these tumors makes their diagnosis and management quite complicated. Fine needle aspiration cytology (FNAC) is a useful diagnostic procedure which has a recognized role in the evaluation of salivary gland lesions. A pre-operative diagnosis about nature of lesion, whether benign or malignant, will help in making decision about proper management of patient. Objective: Aim of this study was to know the incidence of various salivary gland tumors in our region using fine needle aspiration cytology and taking histopathology as the gold standard. Method: It was prospective observational study conducted in department of oral ans maxillofacial surgery in our institute. Total 80 cases were studied with particular reference to age, sex, site, cytologic details & histological types as per WHO classification. FNAC & histopathological examination was done in all cases from the department of Pathology Govt. Medical College Srinagar. Diagnostic accuracy of FNAC was evaluated by comparing cytological & histopathological diagnoses. Results: Maximum number of patients was in age range of 41-50 years & male to female ratio was 2:3. Most common benign & malignant tumors were pleomorphic adenoma (69.89% cases) & mucoepidermoid carcinoma (8.60% cases) respectively. On cytology, 73 cases while on histopathology 76 cases were diagnosed as neoplastic. Conclusion: parotid gland was the most commonly affected site followed by submandibular gland and minor salivary glands. FNAC in salivary gland masses is fairly reliable for correct preoperative diagnosis.