Cryo-EM structures reveal a multistep mechanism of Hsp90 activation by co-chaperone Aha1
David Agard
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Differences in conformational dynamics within the Hsp90 chaperone family reveal mechanistic insights
Matthias P Mayer
Frontiers in Molecular Biosciences, 2014
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Interaction between the N-terminal and Middle Regions Is Essential for the in Vivo Function of HSP90 Molecular Chaperone
Takayuki Nemoto
Journal of Biological Chemistry, 2002
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Diverse Cellular Functions of the Hsp90 Molecular Chaperone Uncovered Using Systems Approaches
Amie McClellan
Cell, 2007
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Conformational dynamics of the molecular chaperone Hsp90
David Agard
Quarterly Reviews of Biophysics, 2011
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Cross-Monomer Substrate Contacts Reposition the Hsp90 N-Terminal Domain and Prime the Chaperone Activity
Matthias P Mayer, David Agard
Journal of Molecular Biology, 2012
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A hydrophobic segment within the C-terminal domain is essential for both client-binding and dimer formation of the HSP90-family molecular chaperone
Takayuki Nemoto
European Journal of Biochemistry, 2002
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Hop: An Hsp70/Hsp90 Co-Chaperone That Functions Within and Beyond Hsp70/Hsp90 Protein Folding Pathways
Graeme Bradley
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ATPase Activity and ATP-dependent Conformational Change in the Co-chaperone HSP70/HSP90-organizing Protein (HOP)
Ganesh Prasad Subedi
Journal of Biological Chemistry, 2014
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Hsp90's secrets unfold: new insights from structural and functional studies
Avrom Caplan
Trends in Cell Biology, 1999
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Structural and Functional Analysis of the Middle Segment of Hsp90: Implications for ATP Hydrolysis and Client Protein and Cochaperone Interactions
Barry Panaretou
Molecular Cell, 2003
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Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1
Matthias P Mayer
Nature Communications, 2019
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Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)-domain co-chaperones
Barry Panaretou
The EMBO Journal, 1999
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The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
Horst Kessler, Michael Groll
The EMBO Journal, 2012
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Hsp90 Oligomers Interacting with the Aha1 Cochaperone: An Outlook for the Hsp90 Chaperone Machineries
Renan Goude, Cyrille Garnier
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N-terminal domain of human Hsp90 triggers binding to the cochaperone p23
Rolf Boelens
Proceedings of the National Academy of Sciences, 2011
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ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone invivo
Barry Panaretou
The EMBO Journal, 1998
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Regulation of Hsp90 ATPase Activity by the Co-chaperone Cdc37p/p50
Barry Panaretou
Journal of Biological Chemistry, 2002
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Dynamics of the regulation of Hsp90 by the co-chaperone Sti1
Matthias P Mayer
The EMBO Journal, 2012
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Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function
Len Neckers, Peter Sheffield
Molecular Cell, 2010
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Structural and Computational Biology of the Molecular Chaperone Hsp90: From Understanding Molecular Mechanisms to Computer-Based Inhibitor Design
Gennady Verkhivker
Current Topics in Medicinal Chemistry, 2009
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Understanding ligand-based modulation of the Hsp90 molecular chaperone dynamics at atomic resolution
Gennady Verkhivker
Proceedings of the National Academy of Sciences, 2008
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Probing molecular mechanisms of the Hsp90 chaperone: biophysical modeling identifies key regulators of functional dynamics
Gennady Verkhivker
PloS one, 2012
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Hsp90: Breaking the Symmetry
Matthias P Mayer
Molecular cell, 2015
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Structural basis for recruitment of the ATPase activator Aha1 to the Hsp90 chaperone machinery
Chunyan Liao
Embo Journal - EMBO J, 2004
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Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94
Feixia Chu
Protein Science, 2006
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Dimerization and N-terminal domain proximity underlie the function of the molecular chaperone heat shock protein 90
Ilham ilhams
Proceedings of The National Academy of Sciences, 2000
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GR chaperone cycle mechanism revealed by cryo-EM: inactivation of GR by GR:Hsp90:Hsp70:Hop client-loading complex
David Agard
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Conformations of the Nucleotide and Polypeptide Binding Domains of a Cytosolic Hsp70 Molecular Chaperone Are Coupled
William Chirico
Journal of Biological Chemistry, 1996
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Molecular chaperones: The busy life of Hsp90
Matthias P Mayer
Current Biology, 1999
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Ligand-induced Conformational Shift in the N-terminal Domain of GRP94, an Hsp90 Chaperone
Robert Immormino
Journal of Biological Chemistry, 2004
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Liberation of the intramolecular interaction as the mechanism of heat-induced activation of HSP90 molecular chaperone
Takayuki Nemoto
European Journal of Biochemistry, 2001
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Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions
Lewis Kay
eLife, 2018
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