Comparing Surfactant Penetration into Human Skin and Resulting Skin Dryness Using In Vivo and Ex Vivo Methods (original) (raw)

Journal of cosmetic science, 2019

Abstract

Numerous tests have been developed to estimate a surfactant's mildness in rinse-off formulations. In this study, mixed surfactant systems were examined for their impact on surfactant penetration into the skin and skin hydration using in vivo and ex vivo methods. A forearm controlled application test (FCAT) was conducted, and skin hydration was evaluated using corneometry and visual dryness grading. Tape strip and cup scrub extractions were completed within the FCAT to examine the penetration of five individual surfactants into the skin in vivo. The ratio of surfactant mass extracted by five pooled tape strips to surfactant mass extracted by cup scrubs was found to be in the range of 40-59%. Furthermore, cup scrub collection and analysis was less time-consuming and less expensive to conduct than tape stripping. Thus, we recommend cup scrub extraction as a suitable substitute for tape stripping in future surfactant skin penetration analyses. In vivo results were compared with ex v...

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