Synthesis, Characterization and Biological Activities of Hydrazone Schiff Base and its Novel Metals Complexes (original) (raw)
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SPECTRAL CHARACTERIZATION AND BIOLOGICAL ACTIVITIES OF HYDRAZIDE SCHIFF BASE METAL COMPLEXES
CORROSION AND PROTECTION, 2023
Schiff bases or azomethines are recognized as privileged ligand in coordination chemistry as they readily form stable complexes with most transition metal complexes. In this paper, a novel schiff base ligand obtain from benzaldehyde and hydrazide moeities and its transition metal [ Mn(II), Co(II), Ni(II) complexes were synthesized. FT-IR, UV-Vis, NMR, Mass, TGA, XPS and ESR spectral techniques were used to confirm the structures of the ligand and metal chelates. The schiff base act as tridentate ligand with O and N donors and coordinates to metal ion along with phenolic oxygen and azomethine nitrogen. The compositions of the ligand and its metal complexes have been established by elemental analysis. Spectral studies suggested that the octahedral geometry arrangement for all metal (II) complexes, having 2:1 ratio (L:M) stoichiometric ratio of the type [M(HMB)2]H2O. The schiff base ligand metal complexes have been screened for antimicrobial activities towards some clinically important microorganism. Also antioxidant activity of schiff base metal complexes were studied by using DPPH and Phosphomolybdenum reagents. The result of the biological activities shown that complexes are more active than schiff base.
Iranian Journal of Science and Technology, Transactions A: Science, 2017
New isatinic hydrazone Schiff-base ligands, namely furan-2-carboxylic acid (2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (L 1), thiophene-2-carboxylic acid (2oxo-1,2-dihydro-indol-3-ylidene)-hydrazide (L 2) and 2-(pyridine-2-yl-hydrazono)-1,2-dihydro-indol-3-one) (L 3) are reported. The ligands were prepared by the condensation of furan-2-carboxylic acid hydrazide (L 1), thiophene-2-carboxylic acid hydrazide (L 2), and 2-hydrazino pyridine (L 3) with isatine. Monomeric complexes were prepared from the reaction of the corresponding metal chloride with the ligands. The ligands and their nine new complexes of the general formulae [M(L n) 2 ]Cl 2 [where M = Co(II), Zn(II) and Cd(II); n = L 1 , L 2 and L 3 ] were characterised by spectroscopic methods (FTIR, UV-Vis, 1 H, 13 C NMR), elemental analysis, metal content, magnetic measurement and molar conductance. These studies revealed the formation of six coordinate complexes, in which the geometry about metal atom is a distorted octahedral. Biological activity of the ligands and their metal complexes against Gram-positive bacterial strain Bacillus (G ?) and Gramnegative bacteria Ecoli (G-) are evaluated. The effects of prepared compounds depend on the type of tested bacteria. It is clear that the ligands and their metal complexes have a potential effect on the Gram-positive (G ?) and Gramnegative (G-) strains of the tested bacteria.
ChemSearch Journal, 2015
Transition metal complexes of Co(II) and Ni(II) with Schiff base ligand (HL) derived from condensation of 2hydroxy-1-naphthaldehyde and hydrazine monohydrate were successfully synthesized and separated. The Schiff base ligand and the metal (II) complexes prepared were characterized by melting point/decomposition temperature, solubility, conductivity, FT-IR spectra and elemental analysis results. IR spectra of the free ligand showed a band at 1655cm-1 which is assigned to the (-C=N-) stretching vibration of the azomethine. This band was observed at lower frequencies in the spectra of the metal (II) complexes which indicate complexation. Low (5.00-7.00Ohm-1 cm 2 mol-1) conductivity measurement obtained showed that the complexes are non electrolyte while elemental analysis result revealed 1:1 Metal-Schiff base ratio. The in vitro antimicrobial assay showed that the compounds are active against most of the bacterial isolates (E. coli, Kleb pneumonia, P. mirabilis, P. aeruginosa, and S. aureus) as well as fungal isolates (C. albicans, F. solani, A. and fumigates). Antioxidant activity of the phenolic Schiff base against 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals was ascertained by employing probit analytical method using SPSS 16.0 software. The IC 50 for the phenolic Schiff base revealed its promising use as an antioxidant.
Zenodo (CERN European Organization for Nuclear Research), 2017
The development of hydrazones Schiff base have been shown a wide variety of biological activities viz. antimicrobial, anticonvulsant, antidepressant, anti-inflammatory, analgesic, antiplatelet, antimalarial, anticancer, antifungal, antitubercular, antiviral, cardio protective etc., The hydrazones consist of azomethine (H-C=NH-) imines possess and deals with an important type of compounds for the new drug development. The researchers have been synthesized, and assay the microbial activities of hydrazones, hydrazone derivatives and its metal complexes. This review has targeted to explore the diversity of hydrazones in biological sciences.
2015
and EPR. The infrared spectral data suggested that the hydrazone Schiff base behaved as tetradentate ligand with ON NO donor sequence towards metal ions. The characteristic resonance signal in 1 H NMR spectrum indicated the presence of azomethine group as a result of condensation reaction. Magnetic moment data and reflectance spectra of Co(II), Ni(II), Cu(II) complexes revealed an octahedral geometry around metal ions with distortion in Cu(II) coordination complex. Low conductance value of Zn(II) complex in DMSO indicated its non electrolytic nature. Schiff base, L and its Zn(II) complex have been screened for their antibacterial (Escherichia coli, Methicillin resistant Staphylococcus aureus , Pseudomonas aeruginosa, Streptococcus pyogenes and Klebsiella pneumoniae) and antifungal activities (Candida albicans, Aspergillus fumigatus, Penicillium marneffei and Trichophyton mentagrophytes (recultured). Complex show more activity than free Schiff base.
Asian Journal of Chemistry, 2013
AJC-12425 N'-(4-Hydroxy-3-methoxyphenyl)methylidene]formic hydrazide (L-1), N'-[-(4-hydroxy-3-methoxyphenyl)methylidene]-3'hydroxynaphthalene-2'-carbohydrazide (L-2) N'-[-(5-methylfuran-2-yl)methylidene]-3'-hydroxynaphthalene-2'-carbohydrazide (L-3), N'-[-1''-(4-fluorophenyl)ethylidene]-3'-hydroxynaphthalene-2'-carbohydrazide (L-4) and N'-[(-1'-(4-chlorophenyl)ethylidene]formic hydrazide (L-5) were synthesized and tested for their antioxidant activity. All these newly synthesized Schiff's bases were treated with Cu(II), Co(II) and Zn(II) chlorides to form their respective complexes. Antioxidant activity of the synthesized ligands (L-1, L-2, L-3, L-4 and L-5), their corresponding metal(II) complexes, salts of the metal used in the complex formation and Trolox (as standard antioxidant) was measured in terms of their ability to scavenge the DPPH free radical. Ligand (L-4) was found to be the best antioxidant among all the ligands. As regards the activity of metal(II) complexes, Zn-L-4 exhibited the best antioxidant activity.
Jundishapur Journal of Natural Pharmaceutical Products, 2018
Novel Schiff base ligand (L1) was derived from 1,2diphenylethane-1,2-dione with O-phenylenediamine and benzophenone and their metal complexes with the transition metals Co (II), Cu (II) and Zn (II) have been prepared by using a molar ratio of ligand: metal as 1:1. These metal complexes were characterised by the various sophisticated techniques like FTIR, UV-Visible, NMR, and Mass spectrophotometry. These characterizations have concluded that the Schiff base ligand formed acts as a tetradentate ligand and coordinates with the transition metals involved through the four azomethine nitrogen atoms. The structure and bonding nature of all the compounds showed that all complexes possessed an octahedral geometry except the Cu (II) complexes which showed a distorted octahedral geometry. Mass spectrum explains the successive degradation of the molecular species in solution. All the synthesized compounds were studied for their in vitro antibacterial, and antifungal activities, against Staphylococcus aureus, Bacillus subtilis, Parveez Gull, Athar Adil Hashmi-Synthesis, characterization and antimicrobial activity of transition metal complexes with Schiff base derived from 1, 2diphenylethane-1, 2-dione with o-phenylenediamine and benzophenone
Zenodo (CERN European Organization for Nuclear Research), 2021
The divalent metal complexes of [Cu(II)(L)(H2O)2] was obtained by the reaction of new hydrazone Schiff base ligand of heterocyclic 2-hydroxybenzylidene)-4-oxopiperidine-1-carbohydrazide (H2L). The metal (II) complex was analyzed and characterized by elemental analysis, some routine spectral techniques viz., FT-Infrared, UV-visible spectroscopy, and powder XRD. The stoichiometric ratio of hydrazone ligand and its Cu(II)metal was observed as 1:1 (M:L) in the complex. The spectral, TG data suggested a tetrahedral structure of Cu(II) complex.
Current Journal of Applied Science and Technology
Benzoylpyridine and nitro benzoic acid hydrazides were used to examine novel Schiff base Co(II), Mn(II), Fe(II), and Cu(II) complexes. Elemental analysis, molar conductance, magnetic measurements and other methods that like FT-IR, UV–Vis and 1H NMR studies have been used to deduce the nature of bonding and structure of these complexes. These studies revealed that the Co(II), Mn(II), Fe(II) and Cu(II) coordinated by four donor atoms in all the complexes. Free radical scavenging activity was determined according to the elimination of radicals from 2,2-diphenyl-1-picrylhydrazyl (DPPH). These compounds were compared to known antibiotics ciprofloxacin and fluconazole in their ability to inhibit the growth of pathogenic bacteria Bacillus subtilis (as gramme positive bacteria), Pseudomonas sp. (as gramme negative bacteria), and fungus Rhizoctonia sp., Alternaria sp., and Fusarium oxysporum. As an antibacterial and antioxidant agent, the complexes are more effective than the ligand. The cop...
Asian Journal of Chemical Sciences, 2019
Two complexes of Cu(II) and Ni(II) with the ligand N- (4-methoxybenzylidene) isonicotinohydrazide, having the formula [M(La)2]2+ (M = Cu(II) and Ni(II)) were synthesized. The ligand was synthesized by the condensation of isonicotinic acid hydrazide (isoniazid) with 4- methoxybenzaldehyde (p- anisaldehyde). The complexes were characterized by FTIR, UV-Vis spectroscopy, molar conductivity, magnetic susceptibility and evaluated for their in vitro antibacterial activity against human pathogens like gram negative Escherichia coli (E. coli) and gram positive Bacillus cereus (B. cereus)strains. The results indicate that all complexes consist of N and O coordination with metals has better antimicrobial activity.