Corona Virus Disease (Covid – 19): A World Threatening Pandemic (original) (raw)
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Review on Covid-19 (Corona Virus Disease - 19)
Virology & Mycology, 2021
The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARSCoV-2 is phylogenetically related to severe acute respiratory syndromelike (SARS-like) bat viruses, therefore, bats could be the possible primary reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broadspectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyse the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak.
2020
The spread of Coronavirus Disease 2019 (COVID-19) to almost every part of the globe making it a global pandemic as resulted to be a global crisis with urgent need of innovative research ideas, mechanisms and strategy to treat, curtail, contain and prevent the spread of the disease. Covid-19 caused by a novel virus SARS-CoV-2. Leaders around the world have being engaging researchers and scientists for possible vaccine for COVID-19. This pandemic has caused instability in social, economy and psychological balance around the world which has resulted to a new way of life (new normal) which might not return to former normal soon. COVID-19 was declared as a global health emergency that poses threat to humanity, hence, it becomes imperative to abridge and ameliorate its effect, as we await the flattening of the pandemic curve and vaccine development. This review summarizes and provides meaningful information for recent and future research related to the viral origin, epidemiology, transmission, pathogenicity, clinical manifestation and diagnosis, management, prevention and control of coronavirus. All countries in the world and all concerned stakeholders should increase the awareness and provide necessary strategies holistically at the community, state, region, national and international levels to combat this disease. Mini-review Article
Novel corona virus-2019 (SARS CoV-2)
International Journal of Research, 2020
Among disparate infectious diseases viral infection in particular challenges survival of mankind across the globe. By superseding those events, 2019 novel (CoVID-19) or SARS-CoV-2 has become a new human health crisis threatening the world. Corona viruses (CoV) are large family of viruses that affects birds and mammals. In humans, Corona virus can cause respiratory tract infection ranging from the common cold to more serious infection such as SARS (Severe acute respiratory syndrome), MERS (Middle East Respiratory Syndrome) and CoVID-19 (Corona Virus Disease 2019) which can also become lethal. The Novel corona virus (CoVID-19) originated in 2019, is a novel virus which has not been identified in humans since past. At present, the source of CoVID-19 is not known. Although the infection is presumed to be in origin, person to person transmission is evident. Many supportive and symptomatic therapies where being carried out by the Medical practitioners as per the instructions of World Heal...
A review on global threat corona virus disease: COVID-19
Journal of Applied Pharmaceutical Research, 2020
Corona virus disease is a kind of viral disease caused by Severe Acute Respiratory Syndrome-CoV 2, which is first witnessed in Wuhan city, China and it can be transmit from human to human. Coronavirus size ranges from (65-125 nm) in diameter and contain a single stranded RNA as nucleic acid material, size ranging from 26 to 32 kbps in length. The sub group of coronaviruses family is Alpha (α) Beta (β) Gama (γ) and delta (δ) coronavirus. Coronavirus disease is a kind of respiratory disease which mainly affects the lower respiratory tract of human body. Initially interferon α normalisation, broad spectrum antibiotic and antiviral drugs was used to reduce the viral load. There may be different kind of mode of transmission of this virus for example Respiratory transmission, Aerosol transmission, Contact transmission and Hospital acquired transmission. There is a well explained safety measures is provided to inhibit the COVID-19 spread which should be followed properly. There are some testing processes also developed to determine the presence of this virus. Till now not even a single vaccine is developed for the treatment of this COVID-19 but more than 12 countries across the globe are undergoing trial for more than 150 vaccine candidates.
A Review: Pandemic Novel Coronavirus (Covid-19)
The Journal of medical research, 2020
The uncontrolled expansion of the novel coronavirus has stirred panic and unwelcoming sentiment and economic loss towards the world. The full spectrum of COVID-19 ranges from mild to severe respiratory illness with severe progressive pneumonia, multiorgan failure, and death. COVID-19 highly transmitted from person to person, thus need to the isolation of patients and maintain the quarantine. Lots of sought gain insights for vaccine design against SARS-CoV-2 (Severe Acute Respiratory Syndrome-Coronavirus-2) by considering the genetic similarities to SARS-CoV. This review article discusses the official updates on coronavirus, symptoms, transmission, diagnosis, reviews on pathogenesis, structure, treatment policy and our opinions on the use of drugs for the treatment of COVID-19 infection.
Novel Corona Virus (COVID-19) -Overview of the Outbreak
https://www.ijrrjournal.com/IJRR\_Vol.7\_Issue.9\_Sep2020/Abstract\_IJRR0023.html, 2020
Novel strain of coronavirus has evolved at the end of 2019 and was labelled as Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), causing severe acute respiratory syndrome expanded globally from Wuhan, China. By the end of March 2020, the World Health Organization declared the COVID-19 virus a global pandemic. A brief review describing the existing literature available regarding Corona Virus epidemiology, clinical manifestations, management and future preparedness required is dealt in this article. Though only when the pandemic ends it will be possible to assess the full health, social and economic impact of this global disaster.
Coronavirus disease‑2019 (Review)
World Academy of Sciences Journal, 2021
From the end of 2019, an ongoing outbreak of a new type of unexplained pneumonia caused by a novel coronavirus, Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China. Since then, it has spread to most parts of China and worldwide, thus affecting the health of individuals worldwide. Until August 2020, >25 million cases of SARS-CoV-2 infection had been confirmed worldwide, causing >800,000 deaths. This disease was named by the World Health Organization as coronavirus disease 2019 (COVID-19). Similar to SARS and Middle East Respiratory Syndrome, which are also caused by coronavirus infections, COVID-19 mainly causes severe respiratory system damage; however, it also causes damage to multiple organs, including the gastrointestinal tract, the cardiovascular system and the nervous system. The main aim of the present review article was to summarize the current knowledge of COVID-19, such as the transmission process, diagnostic methods, pathological characteristics, potential pathogenic mechanisms and treatment measures. Contents
Review of the Corona Viruses Causing Acute Respiratory Syndrome and COVID-2019 (COVID-19) Pandemic
2020
A new virus, Severe Acute Respiratory Syndrome Corona Virus-2 (SARS CoV-2) emerged in December 2019 and still continuing to pose a great threat all over the Globe claiming to a fatality 980,031 persons. Among the human corona viruses it is the third one causing acute respiratory distress syndrome. The others two are SARS CoV and MERS CoV. The objective of this study is to review the human corona viruses causing severe respiratory distresses which are detected thru analysis of some recently published documents on the deadly SARS CoV-2 as well as information on SARS-CoV and MERS CoV from different world class trust worthy reliable and dependable sources. Genetic analysis reveals that the new human corona virus (SARS CoV-2) has similarities with the severe acute respiratory syndrome like (SARS like) bat virus which thought to be the primary reservoir. SARSCoV and MERS-CoV also have same bat reservoir but the intermediate host are different for three human corona viruses. Though the cli...
A REVIEW -CORONA VIRUS (COVID-19
IJRTI, 2020
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm.Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.
Novel Coronavirus (COVID-19)-A Critical Review
2020
No one has even imagined that infection in the respiratory system in the form of pneumonia because of novel coronavirus (SARS-CoV2) in small town of China, Wuhan during end of December in the year 2019 will come out as an extremely communicable infection. The World Health Organization (WHO) has acknowledged the current epidemic as a threat to whole population worldwide. At present, still we have not reached the advanced levels of research to treat and control this contagious disease. Due to lack of information about the pathogenesis and proliferation pathways of this novel corona virus, whole world is looking forward for its exact prophylaxis. On the basis of recent proofs provided by review and research articles from various gen-uine sources, we tried thoroughly to summarize the various factors regarding COVID-19 like its epidemiology, clinical characteristics, diagnosis, treatment and prevention. Through this review we have made an effort to present a com-mon conceptual literature...