Clinicopathologic and survival characteristics of childhood and adolescent non Hodgkin's lymphoma in Yazd, Iran (original) (raw)
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Journal of Cancer Therapy, 2015
Background: Non-Hodgkin's lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin's lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin's lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin's lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8; 1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt's lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specif-* Corresponding author. N. A. Mobark et al. 300 ically for the t (8; 14) (q24; q32) a characteristic genetic feature of Burkitt's Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and high risk ALL CCG 1961 Protocol for lymphoblastic lymphoma and international Anaplastic Large Cell Lymphoma 99 Study Protocol for ALCL. The median follow-up in patients not experiencing an adverse event was 53.1 months. The estimated 3-year EFE and OS rates in the entire cohort of patients with newly diagnosed NHL treated in the KFMC were 85.2% and 89.2% respectively; Overall survival (OS) rate of patients with mature B-cell-NHL was 88.9%. Conclusion: The outcomes and survival in our small series appeared to be excellent compared with those reported in other international trials even though most of our patients presented in advanced stage of the disease. We feel that the importance of the current study is to document the relative distribution of various types of pediatric non-Hodgkin's lymphomas and age-specific distribution in different Histological subtypes.
2016
BackgroundNonHodgkin lymphoma (NHL) is one of the most frequent malignancies in children and adolescents. It represents lymphoid malignancies with diverse clinicopathological and biological features. There are very few studies on the frequency and distribution of NHL in this age group classified according to the WHO classification of 2008. A total of 246 cases with lymphoma were diagnosed in pediatric and adolescent patients over a period of five years, of which NHL accounted for 125 cases. The age, gender, anatomical site and distribution of the different subtypes of NHL were analyzed and compared with similar studies. ResultThe results of our study were comparable to similar studies from India. T-lymphoblastic lymphoma (TLBL) was the most common NHL. Other common subtypes included Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL) and Anaplastic large cell lymphoma (ALCL). ConclusionThe distribution of different subtypes of NHL is similar to other studies from India and ...
Outcome and survival in children with Non-Hodgkin’s lymphoma
Hematology & Transfusion International Journal, 2019
Background Non-Hodgkin lymphoma is the third most common malignant tumor in children. It includes four major subtypes: Burkitt Lymphoma (BL), Lymphoblastic Lymphoma (LL), Diffuse Large B-cell Lymphoma (DLBL) and Anaplastic Large Cell Lymphoma (ALCL). The use of multidrug chemotherapy, radiation therapy, biologic agents, and improved diagnostic and supportive care resulted in better cure rates. Objective This study is to report prognosis and outcome of Non-Hodgkin lymphoma (NHL) patients at tertiary health care facility in King Faisal Specialist Hospital and Research Center, Jeddah (KFSHRC-J). Materials and Method A retrospective cross-sectional study of all eligible patients with Non-Hodgkin lymphoma (NHL), admitted, diagnosed and managed at King Faisal Specialist Hospital and Research Center, Jeddah from Jan 2005 to December 2016, previously untreated, with biopsy proven NHL and Age ≤ 15 years at diagnosis. Clinical data Research Form used to collect patient’s data from medical rec...
Childhood non-Hodgkin malignant lymphomas: A clinicopathologic retrospective study
Medical and Pediatric Oncology, 1979
Between 1968 and 1975,44 evaluable children under 16 years of age with the histologic diagnosis of non-Hodgkin malignant lymphoma (ML) were treated at the lstituto Nazionale Tumori of Milan. Histologic diagnoses were reclassified as follows: 13 lymphoblastic (others) ML, 15 convoluted cell type lymphoblastic ML, 9 Burkitt type ML, and 7 immunoblastic ML. Only 36% of the patients had stage I and I1 disease. At diagnosis 25% showed malignant cells in the bone marrow smears. Bone marrow infiltration was particularly frequent in the convoluted cell type lymphoblastic M L and in the lymphoblastic (others) M L subgroups. Burkitt type M L frequently was associated with abdominal lesions and subsequently a high incidence of central nervous system involvement. Patients with stage I and I1 M L were encountered mostly in the immunoblastic M L subgroup. After 1973 more intensive chemotherapy plus radiotherapy seems to have slightly improved the survival of the patients, except in the Burkitt type M L subgroup.
Disease patterns of pediatric non‑Hodgkin lymphoma: A study from a developing area in Egypt
Molecular and Clinical Oncology, 2014
Non-Hodgkin lymphoma (NHL) accounts for 8-10% of all childhood cancers. NHL collectively represents various lymphoid malignancies with diverse clinicopathological and biological characteristics. In this study, we aimed to describe the epidemiological and clinicopathological characteristics and treatment outcomes of pediatric NHL patients treated at the Pediatric Oncology Unit of Zagazig University Hospital and the Benha Specialized Pediatric Hospital. We conducted a cross-sectional retrospective study by reviewing the medical records of 142 patients admitted with a diagnosis of NHL over a period of 8 years (February, 2004 to February, 2012) in these two Oncology Units. The age at presentation ranged between 2 and 15 years, with a mean ± standard deviation (SD) of 6.1±2.8 years and a male:female ratio of 1.7:1. Abdominal involvement was the most common presentation (73.2%). Burkitt's lymphoma (BL) was the most common NHL subtype (69%), followed by lymphoblastic lymphoma, diffuse large B-cell lymphoma and anaplastic large-cell lymphoma, accounting for 18.3, 10.6 and 2.1% of the cases, respectively. The majority of the patients (88.7%) had been diagnosed with advanced disease (Murphy stage III/IV). Complete remission was achieved in 120 cases (84.5%). A total of 16 patients (11.3%) succumbed to the disease during the first few months and 6 patients (4.2%) remained alive following relapse. The mean follow-up duration ± SD was 34.6±25.1 months (range, 3-84 months). The 5-year overall survival (OS) and event-free survival (EFS) rates were 88.7 and 85.1%, respectively. None of the clinical, epidemiological or pathological variables exhibited a statistically significant association with the OS or EFS. In conclusion, NHL occurs at a younger age, with a higher incidence of BL and advanced-stage disease. The outcome of NHL in our two centers was satisfactory, approaching the international rates.
Presentation of lymphoma in childhood
IAR Consortium, 2023
Background: Lymphomas are the third most common group of malignant tumor in children; they are rapidly growing neoplasm, with a propensity fewer spread dissemination, and should be investigation and treated as expeditiously possible Aim of the study: To study epidemiological, clinical & pathological features of lymphoma in Iraqi children Method: Over a period of 7 years (from January 2003 to December 2009) all the cases diagnosed & treated as lymphoma in the oncology unit of the Child Central Teaching Hospital (Baghdad) were reviewed retrospectively. Result:-the total number of cases studied was 118 cases.40% of cases diagnosed during (2003,2004) while only 5% diagnose in 2007,NHL represent the most common type (80.5%) and HL account for (19.4%). regarding HL : the age range was between (2years-15 years), median age was 7 years , peak age was between (5-9 years) , male /female ratio was 5:1, cervical LAP represents the most common mode of presentation (95.6%). Mixed cellularity was the most histopathological subtype (60.8%), & most of patients with advanced disease stage (III, IV) (65.1%). Regarding NHL: the age range was between (9m-16 years), median age was 8 years, peak age was between (5-9 years) and male /female ratio was 2.1:1. Abdominal mass (distention) was the most common mode of presentation (61%). BL&BLL was the most common subtype (56.8%), &most of patient presented with advanced disease (stage III&IV) 86.2%. Conclusion:-the study show male predominant in both type of lymphoma,NHL was the most common subtype of lymphoma, MC the most common subtype of HL while BL&BLL was the most common subtype of NHL and high percentage of patients (HL&NHL) presented with advanced disease.
Jornal de Pediatria, 2007
Objective: To describe the clinical and demographic characteristics of non-Hodgkin's lymphoma patients diagnosed at the Pediatric Oncology Unit at the Instituto Materno-Infantil Professor Fernando Figueira (IMIP) over a 9-year period, and also to describe their survival rates and possible associations between the survival rates and the clinical and demographic characteristics analyzed in the study. Methods: This was a cross-sectional study. Data were collected by a retrospective review of the charts of all 110 patients admitted to our unit during the period of May 1994 through May 2003. Probability of survival was calculated in accordance with the techniques of Kaplan-Meier, using log rank to evaluate differences between the groups. Results: The average age was 6.1 years. The male/female ratio was 2.4:1. The most frequent histological subtype was Burkitt's lymphoma. The majority of patients had been diagnosed with advanced disease (stage III or IV of Murphy's Classification) and was from rural areas. Family income per capita was lower than 1/2 minimum wage in 36.4% of cases; maternal illiteracy was observed in 12.7% of cases. The 5-year overall survival and disease-free survival rates were 70±4% and 68.4±4%, respectively. None of the clinical-demographic characteristics had a significant association with the probability of survival (p > 0.05). Conclusion: Children admitted to the IMIP seemed to be affected by non-Hodgkin lymphoma at a younger age, with a higher incidence of Burkitt's lymphoma and with survival rates similar to those described in the literature of developed countries. No clinical demographic characteristics had a statistically significant association with prognosis.
Lymphoblastic lymphomas in children: A single-center experience from Serbia
Srpski arhiv za celokupno lekarstvo, 2016
Introduction. Intensive treatment protocols used for non-Hodgkin lymphoma in children lead to eventfree survival rates ranging from 80% to 90%. However, the results are less successful in developing countries. Lymphoblastic lymphoma (LBL) is the second most frequent type of lymphoma in children, contributing with about one third to all non-Hodgkin lymphoma in childhood. Objective. The aim of the study was to evaluate the results of LBL treatment in University Children?s Hospital (UCH), Belgrade. Methods. A retrospective analysis of patient records at UCH from 1997 to 2015 was carried out in patients aged 0-18 years, in whom the diagnosis of LBL had been established. Twenty-two children were included in the analysis. Results. Mean age at diagnosis was 10 years, with preponderance of male patients. All patients were treated according to Berlin-Frankfurt-M?nster-based chemotherapy protocols. With median follow-up of 91.5 months, five-year probability of event-free survival was 79.5% fo...
Indian Journal of Medical and Paediatric Oncology, 2011
Background: The uniqueness of adolescent and young adult (AYA) non-Hodgkin lymphomas (NHL) with respect to biology and treatment have largely remained unanswered due to marked heterogeneity in treatment, paucity of prospective, or retrospective studies and poor representation of AYA in clinical trials. This audit attempts to put forward the clinicopathological attributes and treatment outcomes of AYA NHL treated with both pediatric and adult protocols from a single centre in a developing country. Patients and Methods: Hospital records of all consecutive NHL patients registered in lymphoma clinic from January 2007 to May 2010 were reviewed for information on demography, clinical features, histology subtype, staging, treatment regimen, response rates, toxicities, and follow up. Two-year progression-free (PFS) and overall survival (OS) were calculated with Kaplan-Meier method. Results: AYA NHL constituted 4% of all lymphomas. Diffuse large B-cell (DLBL) was the most frequent subtype. F...