P4-281 (original) (raw)

The marine environment is a rich source of unique natural compounds with potential therapeutic applications, particularly in the field of neurodegenerative diseases like Alzheimer's disease (AD). Screening marine organisms revealed that isopropanolic extracts, particularly from species such as sea stars and blue crabs, demonstrated significant biological activities, especially in inhibiting the beta-site APP cleaving enzyme (BACE). Further isolation led to the identification of polyunsaturated fatty acids (PUFAs) as key components responsible for this activity. Investigation of lipid adducts in AD brains showed a strong correlation with disease pathology, suggesting that scavenging these lipid mediators might offer therapeutic benefit. Additionally, the study explored the multifaceted effects of indirubin, a compound with anti-leukemia properties, which was found to influence both amyloidogenic processing and tau phosphorylation, linking two major disease pathways. These findings suggest new avenues for therapeutic interventions targeting both amyloid and tau pathologies in AD.