Formulation and optimization of orodispersible tablets of flutamide (original) (raw)
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American Journal of Advanced Drug Delivery, 2014
The purpose of this research was to investigate the efficiency of superdisintegrants such crosscarmellose sodium, cross povidone and sodium starch glycolate in formulating orodispersible tablets of Fluoxetine Hydrochloride tablets. Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor drug which is used in psychiatric disorder like depression. The efficiency of three super disintegrants were investigated by wet granulation and sublimation method with different concentratioins of 1.5%, 3% and 4.5%. The preformulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters & the values were within prescribed limits and indicated good free flowing properties. The tablets prepared by wet granulation & sublimation method were evaluated for physical parameters, wetting time, disintegration time, content uniformity and in vitro dissolution. The physical parameters were found to be satisfactory & within the limits. Upon comparison sublimation method was showed good results for disintegration time, wetting time & in vitro drug release studies because sublimation of camphor increases the porosity of the tablets. The tablets prepared with crospovidone at 4.5% concentration (FS-6) by sublimation method was found to be best formulation as it exhibited satisfactory physical parameters, least disintegration time (13 sec.), wetting time (10 sec.) & highest % drug release (99.5%) at 15 mins. In order to determine the mode of release, the data was fitted into various kinetic models and the optimized formulation followed first order kinetics.
2014
In the present work, Flunarizine hydrochloride, an anti-migraine drug has been formulated into fast dissolving tablets by sublimation method using camp hor and menthol as sublimating agents and sodium st arch glycolate as superdisintegrant. Concentrations of t he sublimating agents were varied keeping the conce ntration of superdisintegrant fixed. The aim of the study wa s to prepare fast dissolving tablets with better dr ug releasing profile. The comparative evaluation of selected con centrations of sublimating agents on various physic ochemical properties of tablets was performed. Wetti ng ime, water absorption ratio, In-vitro disintegration time, and drug release was dependent on the concentration of sublimating agents. The fast dissolving tablets were prepared with 0%-26.5% concentration of sublimating agents with optimum concentration of 4% of SSG. Th e blend was evaluated for angle of repose, bulk densi ty, tapped density, compressibility index and hausn er’ ratio. The tablets...
The purpose of the present research was to the effect of camphor as a subliming agent on the mouth dissolving property of famotidine tablets. Method: Orodispersible tablets of famotidine were prepared using camphor as subliming agent and sodium starch glycollate together with crosscarmellose sodium as superdisintegrants. The formulations were evaluated for weight variation, hardness, friability, drug content, wetting time, in vitro and in-vivo dispersion, mouth feel and in vitro dissolution. Result: All the formulations showed low weight variation with dispersion time less than 30 seconds and rapid in vitro dissolution. The results revealed that the tablets containing subliming agent had a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII. The optimized formulation showed good release profile with maximum drug being released at all time intervals. Conclusion: This work helped in understanding the effect of formulation processing variables especially the subliming agent on the drug release profile. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.
FORMULATION, DEVELOPMENT AND EVALUATION OF FAMOTIDINE ORODISPERSIBLE TABLETS
The objective of the present study was to prepare Famotidine as Orodispersible tablets. Orodispersible tablets dissolve rapidly and show higher bioavailability than conventional tablets. Stomach acidity symptoms are treated by many effective drugs; however, they are slow to produce the desirable effect. Therefore, to decrease the patient time in suffering of these symptoms, Orodispersible drug-delivery system significantly increased patient acceptance by virtue of rapid disintegration, self-administration without water and finally improved patient compliance. Famotidine is selective H2 receptor blocker, used in treat duodenal ulcer condition and heartburn. The drug absorbed slowly and incompletely from GIT, bioavailability 40% and onset of action is less than 1hr (Initial; 1hr-4hr (peak), in order to improve onset of action and increase bioavailability Famotidine was developed as Orodispersible tablets. Tablets were prepared by wet granulation and direct compression methods using sodium starch glycolate and croscarmellose sodium and crospovidone as superdisintegrants. The tablets were evaluated for weight variation, thickness, diameter, hardness, friability, wetting time, in-vitro dispersion time, in-vitro disintegration time, assay and in-vitro dissolution study. Hardness and friability data indicated good mechanical strength of tablets. The results of in-vitro disintegration time of F4 and F6 indicated that the tablets dispersed rapidly in mouth within 23.97, 10 seconds and 106.48%, 92.82% of the drug release within 5 minutes respectively. It was concluded that F4 and F6 are the best formulations of Famotidine Orodispersible tablets in order to increase onset of action and bioavailability of drug.
Asian Journal of Biomedical and Pharmaceutical Sciences, 2016
The objective of present study was to formulate directly compressible orodispersible tablets of quetiapine fumarate by sublimation method with a view to enhance patient compliance. A full 32 factorial design was used to investigate the effect of two variables viz., concentration of Indion 414 and camphor. Indion 414 (3-5 % w/w) was used as superdisintegrant and camphor (5-15 % w/w) as subliming agent. The tablets were evaluated for thickness, weight variation, hardness, friability, content uniformity, wetting time, porosity, in vitro disintegration time and in vitro drug release. In vitro dissolution profile revealed faster and maximum drug from formulation F3. SEM study show formation of pores on tablet surface after sublimation of the sublimating agent, thus providing a sufficiently porous structure. This permitted the selection of a batch of tablets with desired disintegration time and improved dissolution rate after oral administration. The F3 batch containing the Indion 414 (5%...
Pakistan journal of pharmaceutical sciences, 2013
Famotidine is generally employed for the treatment of gastric ulcer. The present study was conducted to fabricate famotidine tablets using various diluents. The binder was incorporated to the formulations in different proportions. Both the dry granulation and direct compression techniques were employed to develop the tablets. Physical evaluation of tablets i.e. tablets hardness, friability, weight variation, thickness and diameter was determined. In vitro dissolution studies of the prepared tablets were carried out for 60 min using the USP apparatus II and 900 ml 0.1 M HCl stirred at 37 ± 0.5°C with a speed of 50 rpm. Physical analysis of tablets prepared via direct compression showed satisfactory results regarding the weight variation, hardness and friability, since their respective values were within the BP limits. All the prepared famotidine tablets exhibited diffusion based mode of drug release. 100% release of drug occurred in less than 60 min. The drug release from all the for...
International Journal of Pharmacy and Pharmaceutical Sciences, 2019
Objective: The main aim of the present research work was to formulate fast dissolving tablets of famotidine by direct compression method and to evaluate the effect of synthetic super disintegrating agent on drug release pattern. Methods: The fast dissolving tablets were prepared by using crospovidone, croscarmellose sodium, sodium starch glycolate as superdisintegrants (2, 4 and 6 %w/w), mannitol 20 % and microcrystalline cellulose (44, 46 and 48 % w/w) as a directly compressible vehicle. All the prepared tablets were evaluated for hardness, friability, drug content uniformity, weight variation, disintegrating time, wetting time and in vitro drug release studies. Results: All the prepared fast dissolving tablets formulations were within the Pharmacopoeial standards limits. Based on in vitro drug release studies (>90 % within 30 min), the optimised formulations were optimised tested for the short term stability (at 40 ˚C/75% RH for 3 mo) and drug excipient interaction (fourier transform infrared spectroscopy). Conclusion: Hence, formulation prepared with 6 % w/w of crosspovidine and 44 % w/w of microcrystalline cellulose as emerged as the overall best formulation (>90 % within 30 min) compared to marketed product (>70 % within 30 min). Short-term stability studies on the formulations indicated that there are no significant changes in drug content and in vitro drug release (p<0.05).
International Journal of Pharmacy and Pharmaceutical Sciences
Objective: The objective of this study was to formulate orodispersible tablets containing empagliflozin by direct compression method with sufficient hardness and rapid disintegration time and to study the effect of functionality differences of super-disintegrants on the tablet properties. Methods: A two factor three level factorial design (32) was used for the formulation optimization of orodispersible tablets of Empagliflozin and experimental trials were performed on all possible formulations, in which the amount of β-cyclodextrin, crospovidone and croscarmellose sodium were selected as independent variables (factor) varied at three different levels: low (-1), medium (0), and high (+1) levels. The drug release and disintegration time were used as dependent variables (response). All formulations were characterized for parameters such as diameter, hardness, weight, thickness, friability, disintegration time, drug release. Results: Formulation FD6 having 30 sec disintegration time, 98...
A Review on Formulation and Evaluation of Orodispersible Tablets
Zenodo (CERN European Organization for Nuclear Research), 2023
Oral route is presently the gold standard in the pharmaceutical industry where it is regarded as the safest, most economical and most convenient method of drug delivery resulting in highest patient compliance. Oral delivery of active ingredients includes a number of technologies, many of which may be classified as Orodispersible tablets (ODTs). Orodispersible dosage forms have lured the market for a certain section of the patient population which includes dysphagia, bed ridden, psychic, and geriatric patients. Moreover, Orodispersible tablets shows increased bioavailability as compared to conventional dosage forms. Advancements in the technology arena for manufacturing these systems includes the use of freeze drying, cotton candy, melt extrusion, sublimation, direct compression besides the classical wet granulation processes. This has encouraged both academia and industry to generate new orally disintegrating formulations and technological approaches in this field. This article attempts at discussing the ideal characteristics, advantages and disadvantages, formulation aspects, formulation technologies and future potential of ODTs.