Molecular docking analysis of α2-containing GABAA receptors with benzimidazoles derivatives (original) (raw)
Structural Analysis and Binding Modes of Benzodiazepines with Modeled GABAA Receptor Subunit Gamma-2
Rajasekhara Reddy
2014
View PDFchevron_right
Modeling of α k/γ2 ( k = 1, 2, 3 and 5) interface of GABA A receptor and docking studies with zolpidem: Implications for selectivity
Su Ci
Journal of Molecular Graphics & Modelling, 2007
View PDFchevron_right
Determinants of recognition of ligands binding to benzodiazepine receptor/GABAA receptors initiating sedation
James Cook
European Journal of Pharmacology, 2000
View PDFchevron_right
Computer-aided design of selective ligands of the benzodiazepine-binding site of the GABAA receptor
Vladimir Chupakhin
Doklady Chemistry, 2008
View PDFchevron_right
Synthesis, Structure−Activity Relationships at the GABA A Receptor in Rat Brain, and Differential Electrophysiological Profile at the Recombinant Human GABA A Receptor of a Series of Substituted 1,2-Diphenylimidazoles
Giovanni Biggio
Journal of Medicinal Chemistry, 2005
View PDFchevron_right
Structure and molecular modeling of GABAA receptor antagonists
Daniel Vercauteren
Journal of Medicinal Chemistry, 1992
View PDFchevron_right
Kucken AM*, Teissere JA*, Seffinga-Clark J, Wagner DA, Czajkowski C (2003) "Structural requirements for imidazobenzodiazepine binding to GABA(A) receptors" Molecular Pharmacology 63:289-96.
Jeremy Alden Teissere
View PDFchevron_right
Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABA A ) α 2 Benzodiazepine Receptor
Francesca Salvetti
Journal of Medicinal Chemistry, 2009
View PDFchevron_right
The use of a pharmacophore model for identification of novel ligands for the benzodiazepine binding site of the GABAA receptor
Michael Howard
Journal of Molecular Graphics and Modelling, 2004
View PDFchevron_right
Structural Requirements for Eszopiclone and Zolpidem Binding to the γ-Aminobutyric Acid Type-A (GABA A ) Receptor Are Different
Susan Hanson
Journal of Medicinal Chemistry, 2008
View PDFchevron_right
Conformational changes at benzodiazepine binding sites of GABAA receptors detected with a novel technique
Anne Gonthier
Journal of Neurochemistry, 2005
View PDFchevron_right
Orthosteric and benzodiazepine cavities of the α1β2γ2 GABAA receptor: insights from experimentally validated in silico methods
Alejandro Giorgetti
Journal of Biomolecular Structure and Dynamics
View PDFchevron_right
A Structure-based QSAR and Docking Study on Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4,]benzodiazepines as Selective GABAAα5 Inverse Agonists
Taghi Khayamian
Chemical Biology & Drug Design, 2011
View PDFchevron_right
Agonist-Specific Conformational Changes in the α1-γ2 Subunit Interface of the GABAA Receptor
Joe Steinbach
Molecular Pharmacology, 2012
View PDFchevron_right
3- and 5-Isoxazolol zwitterions: an ab initio molecular orbital study relating to GABA agonism and antagonism
Daniel Vercauteren
Journal of Theoretical Biology, 1987
View PDFchevron_right
Potential anxiolytic agents. 2. Improvement of oral efficacy for the pyrido[1,2-a]benzimidazole (PBI) class of GABA-A receptor modulators
Kris Lulofs
Bioorganic & Medicinal Chemistry Letters
View PDFchevron_right
Identification of amino acid residues responsible for the α5 subunit binding selectivity of L‐655,708, a benzodiazepine binding site ligand at the GABAA receptor
Karine Martin
Journal of …, 2001
View PDFchevron_right
Substituted 3-(2-benzoxazyl)-benzimidazol-2-(1H)-ones: A new class of GABAA brain receptor ligands
Charles Blum
Bioorganic & Medicinal Chemistry Letters, 2000
View PDFchevron_right
A novel GABAA receptor pharmacology: drugs interacting with the a+b- interface
Isabella Sarto-jackson, Werner Sieghart
View PDFchevron_right
A study of the structure–activity relationship of GABA A–benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis
Dongmei HAN
Bioorganic & Medicinal Chemistry, 2008
View PDFchevron_right
Characterization in Rats of the Anxiolytic Potential of ELB139 [1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a New Agonist at the Benzodiazepine Binding Site of the GABAA Receptor
Shahram Akbarzadeh
Journal of Pharmacology and Experimental Therapeutics, 2005
View PDFchevron_right
Molecular docking studies of 1, 3, 4 oxadiazoles Derivatives as anti-convulsive agents
sachin jangra
World Journal of Advanced Research and Reviews
View PDFchevron_right
GABAA Receptor Populations Bind Agonists and Antagonists Differentially and with Opposite Affinities
Gabor Maksay
Journal of Neurochemistry, 1988
View PDFchevron_right
Actions of two GABAA receptor benzodiazepine-site ligands that are mediated via non-γ2-dependent modulation
Holger Rabe, Hartmut Lüddens
European Journal of Pharmacology, 2011
View PDFchevron_right
Investigation of [3H]diazepam derivatives as allosteric modulators of GABAA receptor α1β2γ2 subtypes: combination of molecular docking/dynamic simulations, pharmacokinetics/drug-likeness prediction, and QSAR analysis
Nadjib Melkemi
Structural Chemistry
View PDFchevron_right
Two neighboring residues of loop A of the α1subunit point towards the benzodiazepine binding site of GABAAreceptors
Anne Gonthier
FEBS Letters, 2007
View PDFchevron_right
Structure-Guided Modeling and Binding Studies of GABAA Receptor Subunit Beta-3
sravani saragandla
2013
View PDFchevron_right
An Updated Unified Pharmacophore Model of the Benzodiazepine Binding Site on γ-Aminobutyric Acida Receptors: Correlation with Comparative Models
Craig Morton
Current Medicinal Chemistry, 2007
View PDFchevron_right