Changes in portal blood flow and liver functions in cirrhotics during Ramadan fasting in the summer; a pilot study (original) (raw)
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Effects of Ramadan Fasting on Muslim Patients with Liver Cirrhosis: A Comparative Study
2018
Background : Patients with liver cirrhosis seem to be at increased risk of complications during fasting. This study aimed to assess the effect of Ramadan fasting on liver functions and portal hemodynamics among patients with liver cirrhosis in comparison with healthy subjects. Materials and Methods: Participants were divided into three groups. Group I: patients with liver cirrhosis who fasted during Ramadan (n = 34), group II: patients with cirrhosis who did not fast (n = 8), and group III: healthy volunteers who fasted (n = 30). This study was done from May 2017 to July 2017 and the month of Ramadan began on May 27 th to June 26 th, 2017. Portal hemodynamics were evaluated by portal vein diameter, congestion index (CI), and portal flow velocity. Laboratory investigations were determined before, during, and after Ramadan as an indicator of the changes in the liver functions. Results: There were no dropouts during the study. Among the three groups, portal vein parameters showed stati...
Erciyes Medical Journal, 2021
The aim of this study was to investigate the effects of Ramadan model intermittent fasting (IF) on acute pancreatitis, acute cholecystitis, and acute cholangitis, which is closely related to nutrition. Materials and Methods: This retrospective research study was conducted from 2014 to 2018. Patients over 18 years old with acute pancreatitis, acute cholecystitis, and acute cholangitis were included in the study. Patients with lipid metabolism disorders such as hyperlipidemia, pregnant women, malignancies, viral infections, hepatic insufficiency, and cirrhosis were excluded from the study. A total of 3940 patients were included in the study. Hospital applications in Ramadan were compared with the rest of the year. Results: One thousand eight hundred and sixteen male and 2124 female patients were included in the study. 1797 patients (45.6%) with pancreatitis, 1032 patients (26.2%) with cholangitis and 1015 patients (25.8%) with cholecystitis. Pancreatitis (46.4%), cholangitis (29.8%), and cholecystitis (19.3%) were the most frequently diagnosis in Ramadan. The monthly admission rates were calculated in a 5-year period. It was found that the admission rates were 26.6% more in Ramadan than other months. Ramadan fasting significantly increased acute pancreatitis and acute cholangitis. However, cholecystitis decreased. Both sexes were similarly affected from the Ramadan period. Conclusion: Ramadan model of IF induces an increase in the incidence of acute pancreatitis and acute cholangitis and a decrease in acute cholecystitis. Ramadan model may not be a suitable model for a healthy diet.
A Multicenter Pilot Study of the Effects of Ramadan Fasting
Background /Aim: Muslim patients with liver cirrhosis ask their doctors about Ramadan fasting. Indirect hyper bilirubinemia has been found to increase during fasting in Gilbert's syndrome. There are no available data on the effect of Ramadan fasting on patients with liver cirrhosis. The aim of this study was to evaluate the effects of Ramadan fasting on patients with liver cirrhosis.
Effect of Ramadan fasting on acute upper gastrointestinal bleeding
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013
Prolonged fasting may precipitate or exacerbate gastrointestinal complaints. The aim of this study was to evaluate the relation between Ramadan fasting and acute upper gastrointestinal bleeding (AUGIB), and to assess characteristics of those occurred in the holly month. Retrospective analysis was conducted for all patients, who underwent endoscopy for AUGIB in Ramadan (R) and the month before Ramadan (BR). Epidemiological, clinical and etiological characteristics and outcome of patients having AUGIB were compared between the two periods from 2001 to 2010. Two hundred and ninety-one patients had endoscopy for AUGIB during the two periods study. There was an increasing trend in the overall number of patients in Ramadan period (n = 132, 45.4% versus n = 159, 54.6%), especially with duodenal ulcer (n = 48, 37.2% versus n = 81, 62.8%). The most frequent etiology was peptic ulcer but it was more observed in group R than in group BR (46.2% versus 57.9%, P = 0.04), especially duodenal ulcer...
Diabetes Research and Clinical Practice, 2021
Introduction Growing evidence is suggestive that intermittent fasting likely to improve liver function; however, still the evidences are controversial to draw a definitive conclusion. Therefore, we conducted a systematic review and meta-analysis to estimate the effect size for changes in liver function tests (LFT) in healthy people practicing Ramadan diurnal intermittent fasting (RDIF), and to examine the impact of different covariates using subgroup analysis and meta-regression. Methods: Scientific databases were searched from date of inception in 1950 to the end of July 2020. The liver function tests searched and analyzed were aspartate transaminase (AST), alanine transaminase (ALT), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), bilirubin (BLU), L-lactate dehydrogenase (LDH) and prothrombin time (PT). Results: Twenty studies (601 adult participants in total, aged 18-57 years) conducted in 10 countries between 1987 to 2020 were identified. RDIF-induced effect sizes for the LFT expressed as standardized mean difference (SMD) [95% confidence interval] were: AST (no. of studies K=16, number of subjects N=502, SMD= - 0.257 [-0.381, -0.133], I2=42%); ALT (K = 16, N=502, SMD = - 0.105 [-0.282, 0.07], I2=71%); GGT (K = 2, N=46, SMD = - 0.533 [-0.842, -0.224], I2=0%); ALP (K =10, N=312, SMD= - 0.318 [-0.432, -0.204], I2=0.0%); BLU (K =10, N=325, SMD= - 0.264 [-0.520, -0.007], I2 =70.1%); LDH (K=5, N=145, SMD= - 0.041 [-0.380, 0.298], I2=72%); PT (K=2, N=74, SMD= - 0.027 [-0.732, 0.678], I2=87%). Conclusion: RDIF induces significant but small (AST, ALP, BLU) to medium (GGT) positive changes on LFT, and may confer a transient, short-term protection against fatty liver disease in healthy subjects.
Ramadan fasting: Evidence or expert opinion? Results of preliminary studies
2013
Each year, over a billion Muslims fast worldwide during the month of Ramadan. Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many of them fast conceivably and their clinical condition is prone to deteriorate. This is due to the persistent gap between current expert knowledge and conclusive, strong evidence regarding the pathophysiologic and metabolic alterations by fasting, and the consensus that healthcare professionals should reach, in order to manage various patient groups during this month. In this review, we summarize the results of our initial studies regarding the effects of Ramadan fasting on some clinical conditions including alterations of body composition. We also go through the important clinical results of patients who have had previous history of cardiovascular disease, type 2 diabetes, asthma and renal colic. Our studies have presented some evidence in favor of Ramadan fasting and encourage those with mentioned diseases to consult their physicians and follow medical and scientific recommendations. We attempt to present some relevant evidence clarify future scopes in this area of study, and provide suggestions for future investigations.
The Health Impacts of Fasting During Ramadan
JOURNAL OF NUTRITION FASTING AND HEALTH, 2019
Ramadan is the Holy month of fasting that is obligatory for all normal Muslims who reached at their puberty. Two meals are taken during Ramadan, one is taken before down to prepare themselves for fast is called “Sahur”, and second meal is taken at sunset is called “Iftar”. Fasting is not only a ritual and religious obligation while it has several medicinal significances specially against diet dependent diseases. Fasting significantly helped in the reduction of peptic and duodenal ulcers with the combination of H2-blocker drug, help in the improvement of lipid profile specially in TC and HDL and LDL levels that cause heart failure. During fasting the systolic and diastolic blood pressure improve at greater rate as compare to drugs like Indapamide and Perindopril, a strong evidence revealed that ischemic stroke and cancer can also be improved by intermitted fasting through multiple pathways and factors like BDNF, bFGF, GRP78, Hsp70, tyrosine kinase receptor B (TrkB), fibroblast growt...
Mini-symposium: Ramadan fasting and the medical patient: An overview for clinicians
Ibnosina Journal of Medicine and Biomedical Sciences, 2010
The daytime fasting of Ramadan is observed annually by millions of adult Muslims all over the world. Some may have mild, moderate or severe medical conditions. They may seek advice on feasibility and safety of fasting and/or their management. Physicians ought to have a working knowledge about the religious rules of Ramadan fast and their medical implications. In this article we present a concise summary of the proceedings of a series of symposia. Their objectives were to review the effects of Ramadan fasting on the health of Muslim patients with various chronic medical conditions and to propose practical management strategies. An initial introductory Islamic perspective on fasting to set the scene for the following presentations. The religious rulings excluding patients with acute and chronic medical conditions from fasting were highlighted. The roles of the medical professional in guiding patients on best ways to make informed decisions to fast and feast safely were stressed. Avail...