Plasma redox status and premature onset of senile cataract (original) (raw)

Romanian journal of internal medicine = Revue roumaine de médecine interne, 2007

Abstract

Dysfunction of the lens due to opacification is called cataract. Senile cataract is associated with old age. It is estimated that the need for cataract extractions would be diminished by half if onset of cataract would be delayed by only ten years. It thus appears crucial to have a better characterization of the etiology of cataract to detect modifiable factors. It seems that oxidative stress may play an important role in cataractogenesis. Also, it was demonstrated that some plasma constituents correlate with human cataract location. We supposed that in senile cataract the oxidative insult may be systemic and not only at the lens level. The aim of our study was to evaluate the blood redox status in cataractous patients aged between 50-65. The blood samples were collected from 15 patients with pure nuclear cataract and/or posterior subcapsular cataract, without metabolic or somatic diseases and from 15 age and sex matched controls. Carbonyl content of plasma proteins was evaluated wi...

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