Factors Influencing Immunity Toward SARS-CoV-2 Infection (original) (raw)

SSRN Electronic Journal

Abstract

The coronavirus disease (COVID-19) is a highly pathogenic viral infection caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). World Health Organization (WHO) announced the COVID-19 outbreak as a pandemic on 11 March 2020. The B cells in our immune system play a major role in protecting against viruses, bacterium, or other pathogens by producing different classes of antibodies. This study aimed to evaluate the correlation between antibodies production (IgG and IgM) and several factors; age, sex, co-morbidity diseases, patient’s blood group, and Chest computed tomography (CT) findings. IgG and IgM antibody levels were determined for 500 COVID-19 Russian patients. There was a significant inverse correlation (χ2 = 92.53, df = 2, P < 0.001) between IgG antibody production and disease severity determined by CT scan. However, other clinical factors, such as blood group, and co-morbidity diseases, were not significantly associated with antibody production among COVID-19 patients. from the results in this study show that lung damage finding in CT decreases the immune system’s capacity and worsens symptoms and severity of COVID-19. Funding Statement: This paper has been supported by the RUDN University Strategic Academic Leadership Program. Declaration of Interests: The authors declare no conflict of interest. Ethics Approval Statement: The Ethical Committee approved the study of Clinical studies at the Peoples' Friendship University of Russia. (IRB no. 2019-0300/1198).

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