Relationship Between Estimated Glomerular Filtration Rate With Plasma Lipid Levels In Non-Dialysis Diabetic Kidney Disease Patients (original) (raw)
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Collegium antropologicum, 2013
Studies have generally suggested a positive association between dyslipidemia and chronic kidney disease, but sparse data are available on the relation of lipids and glomerular filtration rate in patients with normal renal function. We investigated the associations of serum lipids, including total, LDL, HDL, VLDL cholesterol, and triglyceride levels with estimated glomerular filtration rate (eGFR) in type 1 diabetic patients. Study included 313 normoalbuminuric type 1 diabetic patients with normal or mild decrease (eGFR > 60 mL/min per 1.73 m2) renal function and before any interventions with statins, ACE inhibitors or angiotensin II receptor blockers. eGFR was significantly associated with total, LDL, and HDL cholesterol (r = -0.21, -0.18, and -0.17, respectively, for all p < 0.05). Stratifying serum lipids for degree of eGFR, levels of total, LDL, and HDL cholesterol were inversely related to eGFR, but trends were significant only for total (5.1 vs 5.0 and 4.6 mmol/L) and LDL...
A study of lipid profile in non-diabetic chronic kidney disease
International Journal of Advances in Medicine, 2016
Chronic Kidney Disease (CKD) is a worldwide health problem. Prevalence of CKD in the United States is increasing and affects about 19 million Americans. 1 The United States has seen a 30% increase in patients suffering from CKD in the last decade. 2 Over the last decade, it was established that CKD is associated with a very high mortality rate and accelerated Cardio-Vascular (CV) disease. 3 Recent studies suggest that the risk for death is increased in individuals with less severe impairment of kidney function that does not require dialysis when compared to those who have preserved kidney function. In patients who finally advance to ESRD ABSTRACT Background: The present study focused on finding an approximate prevalence of dyslipidemia in the target reference population and the association with staging and management strategy used. An effort was also made to know the alteration in different lipoprotein fractions in chronic kidney disease. The objective of the study was to study the lipid profile in non-diabetic patients with chronic kidney disease. Methods: The study was conducted in Ispat general hospital, Rourkela and data was collected from January 2014 to September 2015. Patients who were diagnosed with Chronic Kidney Disease admitted into the medical ward and dialysis unit of Ispat General Hospital, Rourkela, Odisha, who had willingly given their informed written consent for this study were the source of data. For diagnosis of CKD, history and clinical features with supportive biochemical and radiological evidence were taken as criteria. Patients with already known diabetes mellitus were excluded. Results: The prevalence of dyslipidemia in CKD was found to be about 65.%. And the prevalence was increasing with the increase in severity of the disease. There was a significant rise in the serum triglyceride concentration in the study population. This abnormality was followed by a fall in HDL cholesterol and rise in the total Serum cholesterol in patients suffering from CKD. On comparing patients with CKD on hemodialysis with that on conservative management there is a significant prevalence of dyslipidemia in the Hemodialysis group. There is a significantly higher level of triglycerides and Serum cholesterol and a significantly lower level of HDL cholesterol in the hemodialysis group. Conclusions: The high prevalence of lipid abnormalities in CKD may accelerate the progression of CVD and increase the mortality of patients. Hence it is worthwhile to test and detect patients at high risk early on and manage accordingly.
Characteristics of the Lipid Profile in Patients with Diabetes Mellitus and Chronic Kidney Disease
Romanian Journal of Diabetes Nutrition and Metabolic Diseases, 2017
Background and aimsDiabetes mellitus (DM) is one of the leading causes of end-stage chronic kidney disease (CKD). Patients with DM and CKD have a 10 or even 20 times higher cardiovascular risk (CVR) than the general population. Lipid metabolism disorders are more frequent in these patients, dyslipidemia being aggravated by the presence of hyperglycemia and insulin resistance. The main purpose of our study was to identify possible correlations between lipid profile parameters and altered renal function in patients with DM. We have also analyzed the correlations between lipid parameters, CKD, quality of glycemic control and CVR.Material and method:The study was performed on 2732 patients with DM which received medical treatment and care at the Center for Diabetes Timisoara, for a 6-month period from March to October 2016, 1508 women (55.2%) and 1224 men (44.8%), mean age 63.7 ± 9.1 (33-78) years and mean diabetes duration 12.4 ± 6.8 (6-33) years. The study group included 312 patients ...
IJPPS, 2020
Objective: Chronic Kidney Disease (CKD) is a silent epidemic of the 21 st century. Cardiovascular disease (CVD) is a major cause of morbidity and mortality among patients with CKD. This study aims to evaluate the type of dyslipidemia in CKD patients and correlates with the severity of renal dysfunction in CKD patients. Methods: The observational study was conducted in the Department of General Medicine, PRM MCH, Baripada between May 2018 and January 2019. 262 patients of CKD above 15 y of age, satisfying the inclusion and exclusion criteria were included in the study. Results: Out of 262 patients, 64.50% (169) were male and 35.50% (93) were females with M: F of 1.8:1. The age range was from 20 to 95. The average age of the patients in the study was 56.66+12.22 y. 45.04 % (118) of the patients were between 46 and 60 y of age. 68.70% of the patients had dyslipidemia. The comparison between lipid profiles of cases and controls showed a significant increase in total cholesterol, triglyceride, LDL and decrease in HDL. Conclusion: The prevalence of dyslipidemia in non-diabetic CKD is high. A high degree of abnormality is found in HDL with disease progression, which is statistically significant. Therefore, maintenance of desired lipid levels either through diet or early initiation of lipid-lowering drugs can be helpful in decreasing the risk of cardiovascular complications in CKD patients.
Evaluation of Lipid Profile in Patients with Non-Diabetic Chronic Kidney Disease Stage 3, 4 And 5
INTRODUCTION: Chronic kidney disease is a prevalent health problem worldwide, affecting millions of people. Dyslipidemia has been identified as an independent risk factor for the progression of renal disease. In chronic kidney disease, the most prevalent lipid abnormalities which have been noted are increased triglyceride levels and decreased HDL concentration. The LDL levels are usually normal or increased. MATERIAL& METHODS: The study was conducted at King George Hospital(KGH), Visakhapatnam from May 2018 to April 2019. It was an analytical, observational, cross-sectional study conducted in non-diabetic chronic kidney disease patients of age group 18 to 65 years admitted in medical and nephrology wards.A total of one hundred and twenty patients were enrolled in the study. A detailed medical history and clinical examination were performed in all patients. Demographic data like age sex were collectedAn early morning venous sample was collected and sent for Fasting blood sugar, Hb A1C, Blood urea, serum creatinine, Serum electrolytes, Lipid profile (total cholesterol, triglycerides, HDL, LDL and VLDL). RESULTS: Of 120 patients, 42 were on maintenance hemodialysis and 78 were on conservative management. The number of patients in stage 3 were 20 (16.6%), in stage 4 were 44 (36.6%) and 56 (46.6%) in stage 5. 33 patients have normal lipid profile, and 45 were abnormal in conservative management group and eight patients have normal lipid profile, and 34 have an abnormal lipid profile in hemodialysis group. CONCLUSIONS: Prevalence of dyslipidemia in non-diabetic CKD and this problem of dyslipidemia increases as the severity of CKD increasing.A high degree of abnormality found in triglyceride levels in the form of hypertriglyceridemia in non-diabetic CKD patients.
Study of Lipid Profile in Chronic Kidney Disease Patients
Journal of Medical Science and Clinical Research, 2019
Background: Chronic kidney disease (CKD) is associated with premature atherosclerosis and increased incidence of cardiovascular morbidity and mortality. Several factors contribute to atherogenesis and cardiovascular disease in patients with CKD. Notable among the CKD-induced risk factors are lipid disorders, oxidative stress, inflammation, physical inactivity, anemia, hypertension, vascular calcification, endothelial dysfunction, and depressed nitric oxide availability. Objective: To assess the pattern of lipid profile in chronic kidney disease patients along with comparison of lipid profile in chronic kidney disease patients with diabetes mellitus and without diabetes mellitus. Methods: A total of 50 patients of chronic kidney disease (CKD)of age group 20-70 year and 50 age and sex matched healthy controls were included in this study. Blood specimens were collected from both groups and measurement of the lipid profile, FBS, PPBS, S.creatinine and blood urea was done and compare results with the study group. Results: Total cholesterol and LDL was significantly raised in patients of CKD compared to controls. The triglycerides were elevated. However, the statistical analysis showed that it was not significant. There was statistically significant variation found in triglyceride, VLDL and HDL when compared with the comorbid conditions of hypertension. Conclusion: There is significant amount of dyslipidemia is found in patients of CKD. so treatment of dyslipidemia will reduce mortality in CKD patients.
IP innovative publication pvt. ltd, 2019
Introduction: Several factors contribute to atherogenesis and cardiovascular disease in patients with CKD. Notable among the CKD-induced risk factors are lipid disorders, oxidative stress, inflammation, physical inactivity, anemia, hypertension, vascular calcification, endothelial dysfunction, and depressed nitric oxide availability. Objective: The objective is to Measure lipid profile in a patients of chronic kidney disorder (CKD) and compare their level with healty control. Materials and Methods: Study includes total 100 particpants. Among them 50 patients of CKD of age group between 20 to 70 year and 50 healthy controls. Fasting blood samples were collected from both groups and measurement of the lipid profile, FBS, PPBS, serum creatinine and blood urea was done. Results: There is increased level of serum cholesterol and triglyceride was found in CKD patients as compared to control group but when we compared it with control group by calculating p value the difference of significance was found only in case of cholesterol level. Serum LDL was also significantly raised in patients of CKD compared to controls. Conclusion: There is significant amount of dyslipidemia is found in patients of CKD. So treatment of dyslipidemia will reduce mortality in CKD patients.
Status of Lipid Profile in Different Stages of Chronic Kidney Disease
2014
Objective: To estimate and compare dyslipidemia in patients with different stages of chronic kidney disease as compared to healthy controls and to determine whether dyslipidemia is independently associated with rapid renal impairment. Methods: This study was conducted in department of Biochemistry Basic Medical Institute (BMSI), Jinnah Postgraduate Medical Centre (JPMC) Karachi. A total of 150 participants were recruited for the study from the Nephrology department of JPMC. These were grouped as 30 stage II CKD patient, 30 stage III CKD patient, 30 stage IV CKD patient, 30 stage V CKD patient and 30 normal healthy individuals. Cholesterol, triglyceride, high density lipoprotein, low density lipoprotein, urea and creatinine were measured by commercially available kit method. Statistical analysis was done using SPSS version 11. Results: Serum Cholesterol, Triglyceride and LDL-C among all groups were significantly increased when compared with control p<0.05. Serum HDL-C among all st...
Diabetes & Obesity International Journal, 2017
Dyslipidemia is a common occurrence in type 2 diabetes mellitus (T2DM) patients and plays the major role in accelerated risk of cardiovascular disease (CVD) and possible causes chronic kidney disease (CKD), the progression of which leads to end-stage renal disease. A total of 266 T2DM patients were categorized into 2 groups according to their TG/HDL-C ratio of 2.5 and <2.5. The comparison of the clinical characteristics in these 2 groups demonstrated that Glucose, HbA1c, total Cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) levels, TG/HDL-C ratio were significantly higher, while high density lipoprotein cholesterol (HDL-C) and estimated glomerular filtration rate (eGFR) were significantly lower in the group with TG/HDL-C ratio 2.5 (p<0.05). Multiple logistic regressions demonstrated elevated TG/HDL-C ratio associated with CKD and increased HbA1c. The ORs and 95 % CIs were 4.94 (2.45, 9.96), 2.29 (1.13, 4.65) after adjusting for their covariates. Elevated TG/HDL-C ratio was associated with CKD and HbA1c and may increase the rate of disease progression and predict decline in kidney function and structural damage in these T2DM patients.
Serum lipid profiles in patients with chronic kidney disease in a Saudi population
Endocrinology&Metabolism International Journal, 2019
Background and objective: Chronic kidney disease (CKD) is an increasing public health issue. Serum lipids might be independent risk factors for CKD. We aim to examine the association of serum lipid profiles, lipid ratios with CKD in a Saudi population. Methods: We analyzed 3602 participants whom are between the ages 18 to 98 years. All patients were from the population of the diabetic centre and Primary health centre