To compare the safety, efficacy and tolerance of intravaginal PGE 1 tab with intravaginal PGE 2 gel in induction of labour (original) (raw)
Related papers
2011
Objectives: To compare the safety and efficacy of low dose misoprostol and dinoprostone for cervical ripening and labor induction Methods: It was an open label randomized controlled trial conducted at department of Obstetrics & Gynecology, Dr TMA Pai Rotary Hospital, Karkala. The main outcome measure was induction-to-vaginal delivery interval. Secondary outcome measures were the labor characteristics, maternal complications and neonatal outcomes. Results: Out of 320 eligible women included for final analysis, 159 received misoprostol and 161 dinoprostone. There was no significant difference between the two groups in induction-to-vaginal delivery interval, mode of delivery, number of women delivering within 24 hours and neonatal outcomes. The efficacies of the two prostaglandins were similar. Conclusion: Low dose misoprostol is as efficient as dinoprostone in achieving active labor and delivering with in 24 hours. The maternal and neonatal outcomes associated with each group were similar. It is a cheaper alternative for labor induction.
— Cervical ripening is an essential factor for initiation of normal labour for vaginal delivery. Prior to onset of spontaneous labour the cervix undergoes a gradual process of ripening. But in certain cases it does not occur spontaneously at term and sometimes induction of labour is required. Then cervical ripening means high bishop score in essential for successful induction of labour. This comparative study was conducted at Bikaner to compare induction of labour by vaginal prostaglandin E1 tablet (tablet Misoprostol 25 µg 4 hourly) and Intra cervical Dinoprostone gel 0.5 mg. For this purpose 100 clients were given vaginal prostaglandin E1 tablet (tablet Misoprostol 25 µg 4 hourly) and 100 clients were given Intra cervical Dinoprostone gel 0.5 mg. It was observed in this study that Dinoprostone gel is more efficacious for cervical ripening and labour induction in cases of nulliparous & primiparous at term with unfavourable cervix with intact membranes, as compared to misoprostol in terms of shorter total duration of labour, shorter mean induction delivery interval, more spontaneous vaginal deliveries, and reduced incidence of LSCS as well as instrumental deliveries.
Background-This was a comparative study conducted to compare safety and efficacy of 25mcg intravaginal misoprostol with intracervical dinoprostone gel for induction of labour. Methods-100 patients with an indication of labour induction were included in this prospective cross sectional study conducted at Nalanda Medical College and Hospital from January 2018 to December 2018. 50 of them received 25mcg intravaginal misoprostol every 4 hourly for a maximum of 6 doses and 50 of them received 0.5mg intracervical dinoprostone gel for a maximum of 3 doses. Results-The mean induction-delivery interval of the misoprostol was shorter 11.8±2.03 hours as compared to the dinoprostone group 15.54±2.63 hours (pvalue=<0.0001), 44% subjects required oxytocin augmentation in the misoprostol group and 70% in the dinoprostone, indicating that misoprostol group required less oxytocin augmentation(p=0.0086). 84% delivered vaginally in the misoprostol group and 80% in the dinoprostone group(p=0.602). No significant difference was found in terms of intrapartum complications and fetal outcome. Conclusion-25mcg intravaginal misoprostol is safe and effective induction agent and has significant shorter induction-delivery interval, when compared to intracervical dinoprostone gel. It is stable at room temperature and is cost effective.
International Journal of Reproduction, Contraception, Obstetrics and Gynecology
Background: The aim of this study was to compare the low dose of vaginal misoprostol and dinoprostone gel for the induction of labour at term of pregnancy.Methods: The study was conducted on 90 women, randomized into two groups, each group having 45 women. First group received misoprostol per vaginally and second group received the dinoprostone gel. The duration of induction to delivery interval, mode of delivery and complications related to labour or foetus were recorded.Results: The mean induction to delivery interval in the misoprostol group was 11.68 ± 4.49 hours and in the dioprostone gel group was 14.85 ± 7.08 hours. Applying the modified t-test, this difference is statistically significant (P value 0.004). Thus misoprostol leads to early labour and early delivery as compared to dinoprostone gel.Conclusions: As shown in this study, vaginal misoprostol is highly effective induction agent with no adverse effect on the outcome of labour as compared to dinoprostone gel.
A Comparison of Misoprostol and Dinoprostone Gel for Induction and Cervical Ripening
National Journal of Medical Research, 2022
Introduction: Labour induction at term is a universal conventional obstetric interference with an objective to stimulate uterine contractions artificially to attain a spontaneous vaginal delivery. The current study was aimed to compare the efficacy and safety profile of low dose vaginal Misoprostol with Dinoprostone gel for induction of labour in term pregnancies with unfavorable cervix and intact membranes. Methodology: This Randomized Controlled Trial was conducted among pregnant women with term pregnancy with obstetrical or medical indication for induction of labour after institutional ethical committee approval. A detailed history, complete physical examination and investigations were done for all patients. Result: Misoprostol and Dinoprostone gel are equally effective inducing agents. Both are equally effective in Primigravida and Multigravida. Failure of induction rate for Misoprostol and Dinoprostone was statistically not significant. The need of Oxytocin augmentation, maternal complication rate, NICU admission rate, caesarean section rate and occurrence of meconium-stained liquor are statistically not significant in both the study groups. Our study was unable to demonstrate superiority of any single drug compared to other. Only the difference is cost, induction with Conclusion: considering the easy to preserve and administer, we recommend use of Misoprostol as a safe, effective, cheaper, and more convenient drug for induction of labour.
Nepal Journal of Obstetrics and Gynaecology, 2014
Aim: To compare the safety and efficacy of two commercially available prostaglandin analogues, misoprostol and dinoprostone as cervical ripening agents. Methods: Patients with a term, vertex, singleton pregnancy and a Bishop score of 4 or less were randomly assigned to receive misoprostol pessary (n = 35, 50 μg intravaginally, maximum dose of up to six pessary) or dinoprostone gel (n = 31, 0.5 mg intracervically; administered twice 6hrs apart). Patients were monitored throughout the period. If there was no progress in cervical dilatation or effective uterine contraction even after maximum dose of dinoprostone or misoprostol, patients were taken for cesarean section. Patients who were able to achieve Bishop’s score more than 7 but the delivery was not progressing, were augmented with intravenous oxytocin infusion. Result: Both drugs were found to be equally effective in improving Bishop’s score. There was significant reduction in the need for oxytocin augmentation in misoprostol (37....
International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017
Background: This randomized prospective study was conducted in the department of obstetrics and Gynaecology Batra Hospital and Medical Research centre from 1st March to 30th April 2008 to compare the safety and efficacy of intravaginal misoprostol and intracervical dinoprostone gel (cervigel) for cervical ripening and induction of labour.Methods: 80 women were recruited in the study. 40 women were administered misoprostol tablet 25ug vaginally while the other 40 were given intracervical cervigel.Results: A total of 85.1% (68 patients) delivered vaginally (33 in the misoprostol group and 35 in the cervigel group) i.e. spontaneous vaginal and assisted vaginal deliveries. The mean interval from start of induction to vaginal delivery was 707.63+146.511 minutes in the misoprostol group and 833.13 +144.36 minutes in the cervigel group with p=0.001 which was significant statistically. Though both the groups showed a favourable change in Bishop’s score after induction but this was not stati...
International Journal of Research in Medical Sciences
Background: This hospital-based, prospective, comparative interventional study aimed to compare the effectiveness of sublingual misoprostol and intracervical dinoprostone gel for induction of labor in primigravida women. Methods: A total of 100 patients were alternately assigned to induction with either Misoprostol 25mcg 6 hourly or dinoprostone Gel 0.5mg 6 hourly. Results: The induction delivery interval was significantly longer in the dinoprostone group compared to the misoprostol group. The incidence of fetal distress was slightly higher in the Dinoprostone group, but the difference was not statistically significant. There were no significant differences between the two groups in the incidence of respiratory distress, birth asphyxia, and APGAR 1 MIN <6. Conclusions: This study suggests that sublingual misoprostol (a type of prostaglandin E1, or PGE1) is more effective than intracervical dinoprostone gel (a type of prostaglandin E2, or PGE2) for cervical ripening and induction ...
2020
Introduction: Induction of labor (IOL) is an increasingly common obstetric procedure. Methods for labor induction include both mechanical and pharmacological options.The only definitive treatment is delivery and it can be achieved by various methods ranging from induction of labour (with inducing agents) to operative vaginal delivery and abdominal surgery. This study was undertaken to compare the efficacy and safety of induction of labour with two inducing agents – intracervical dinoprostone gel and vaginal misoprostol tablet, in women with hypertensive disorders of pregnancy. Material and methods: A comparative study between intracervical dinoprostone gel and vaginal misoprostol for induction of labour in women with hypertensive disorders of pregnancy was performed in the Department of Obstetrics and Gynecology at RMSPH, VIMS, Kolkata. Study includes 100 number of cases for the above study. It was a prospective clinical study. The cases were randomly allocated in two groups; one gr...