Trend of head circumference as a predictor of microcephaly among term infants born at a regional center in Malaysia between 2011-2015 (original) (raw)
Related papers
Ultrasound in Obstetrics & Gynecology, 2016
Objective To evaluate the prediction of microcephaly at birth (micB) using established and two new reference ranges for fetal head circumference (HC) and to assess whether integrating additional parameters can improve prediction. Methods Microcephaly in utero was defined as a fetal HC 3SD below the mean for gestational age according to Jeanty et al.'s reference range. The records of cases with fetal microcephaly (Fmic) were evaluated for medical history, imaging findings, biometry and postnatal examination/autopsy findings. Microcephaly was confirmed at birth (micB) by an occipitofrontal circumference (OFC) or a brain weight at autopsy 2SD below the mean for gestational age. The new INTERGROWTH-21 st Project and a recent Israeli reference for fetal growth were applied for evaluation of the Fmic positive predictive value (PPV) for diagnosis of micB cases. Optimal HC cutoffs were determined for each of the new references with the aim of detecting all micB cases whilst minimizing the number of false positives found to have a normal HC at birth. We also assessed the difference between the Z-scores of the prenatal HC and the corresponding OFC at birth, the frequency of small-for-gestational age (SGA), decreased HC/abdominal circumference (AC) and HC/femur length (FL) ratios, the prevalence of associated malformations and family history.
Prevalence and Associated Factors of Neonatal Microcephaly in Thailand, 2014-2018
2019
Microcephaly became of high concern after Zika outbreaks occurred worldwide. An estimation of its prevalence is crucial for public health preparedness and response. The objectives of this study were to estimate the prevalence of neonatal microcephaly in Thailand during 2014-2018, describe its epidemiological characteristics, and identify associated factors. This study was a cross-sectional study using data from the Health Data Center, Ministry of Public Health, Thailand. Neonatal microcephaly, as defined in this study, is a condition where a newborn has a head circumference (HC) less than the 3 rd percentile of the International Fetal and Newborn Growth Consortium for the 21 st Century standard head circumference charts for term newborn, and Fenton's growth charts for preterm newborn by gestational age and gender. Univariate and multivariate analysis were performed to identify associated factors. During 2014-2018, 121,448 newborns were identified and the prevalence of neonatal m...
Factors associated with small head circumference at birth among infants born before the 28th week
American Journal of Obstetrics and Gynecology, 2010
for the ELGAN Study Investigators OBJECTIVE: We sought to identify risk factors for congenital microcephaly in extremely low gestational age newborns. STUDY DESIGN: Demographic, clinical, and placental characteristics of 1445 infants born before the 28th week were gathered and evaluated for their relationship with congenital microcephaly.
Gender-Specific Reference Charts of Fetal Head Circumference in a Singaporean Population
Annals of the Academy of Medicine, Singapore, 2017
INTRODUCTION With the global outbreak of Zika virus and its association with microcephaly, an up-to-date fetal head circumference (HC) nomogram is crucial to offer a reference standard in order to make an accurate diagnosis. This study was conducted to revise the local fetal HC nomogram. MATERIALS AND METHODS In this retrospective study, ultrasound data was used for construction of the fetal HC nomogram from a total of 6155 pregnancies in the ethnic Chinese population with low risk profile at KK Women's and Children's Hospital over a 10-year period. Regression model was fitted to calculate the mean and standard deviation of HC at each gestational age (GA). Comparison of HC between ethnic groups (no significant differences) and genders were made. The revised chart was compared with another commonly used reference chart (Hadlock). In an independent test population, different reference charts were used to estimate number of cases with microcephaly. RESULTS A statistically signi...
Scientific Reports
Neonatal head circumference (HC) not only represents the brain size of Homo sapiens, but is also an important health risk indicator. Addressing a lack of comparative studies on head size and its variability in term and preterm neonates from different populations, we aimed to examine neonatal HC by gestation according to a regional reference and a global standard. Retrospective analysis of data on neonatal HC obtained from the Lithuanian Medical Birth Register from 2001 to 2015 (423 999 newborns of 24–42 gestational weeks). The varying distribution by gestation and sex was estimated using GAMLSS, and the results were compared with the INTERGROWTH-21st standard. Mean HC increased with gestation in both sexes, while its fractional variability fell. The 3rd percentile matched that for INTERGROWTH-21st at all gestations, while the 50th and 97th percentiles were similar up to 27 weeks, but a full channel width higher than INTERGROWTH-21st at term. INTERGROWTH-21st facilitates the evaluati...
Journal of Neuroimaging
BACKGROUND AND PURPOSE: Measuring head circumference (HC) in infants is an easy screening procedure with which to detect abnormalities in brain growth. It has been demonstrated that HC can predict total brain volume (TBV) in very-lowbirth-weight (VLBW) infants. However, the correlation between HC and TBV was weaker than that observed in healthy term-born toddlers, suggesting that there are factors that influence the relationship between HC and TBV. The aim of this study was to identify the clinical risk factors that caused a deviation from the regression line obtained between HC and TBV. METHODS: The study population was based on 37 VLBW infants, who underwent a clinical magnetic resonance imaging (MRI) examination at a term-equivalent age, during 2013-2015, at Toyama University Hospital. The HC and the TBV were both adjusted for sex, multiple births, and postmenstrual age. The relationship between TBV/HC and clinical characteristics was evaluated. RESULTS: There was a positive correlation between HC and TBV (r = .58, P = .000168). Two clinical factors, the lower birth body weight (BBW) (r = .38, P = .02) and dolichocephaly (r = 0.46, P = .006), were identified as factors that negatively affected the TBV/HC ratio. After excluding infants with low BBW or with dolichocephaly, the correlation between HC and TBV was higher (r = .63). CONCLUSIONS: Although HC has predictive value for TBV in VLBW infants, care should be taken in infants with low BBW (BBW less than 600 g) or dolichocephaly (MRI-based cranial index less than .68), which were related to overestimation of TBV.