An original pharmacoepidemiologic - pharmacodynamic method: application to antipsychotic-induced movement disorders (original) (raw)

Pharmacovigilance databases are usually used to detect new potential signals relevant for drug safety. They are seldom used for explanatory purposes, e.g. to understand the mechanisms of adverse drug reactions (ADRs). The aim of the present study was to combine pharmacovigilance and pharmacodynamic data to investigate the association between D2, 5HT2A, and M1 receptor occupancy and the risks of antipsychotic (AP)-induced movement disorders. First, we performed a case non-case analysis using spontaneous reports from the World Health Organization (WHO) Global Individual Case Safety Report (ICSR) database, VigiBase®. We thus measured the risk of movement disorder reporting compared to all other ADRs (expressed as a Reporting Odds Ratio) for antipsychotics (APs). Second, we performed a linear regression analysis to explore the association between the estimated risk of reporting for individual drugs and their receptor occupancy properties for D2, 5HT2A, and M1 receptors. FGAPs were found...