Formulation, development and evaluation of sennoside enriched Senna extract tablets of different concentrations (original) (raw)
Related papers
Pharmacognostical and biological studies on Senna & its products: an overview
International journal of pharma and bio sciences, 2010
Senna has been traditionally used as laxative by ci vilizations across the world. Leaflets are the prim ary parts used for medicinal purposes. Senna pods are a lso used for making sweetened decoctions for use as laxative. Senna leaflets contain sennosides as main phytoconstituents. The present article is aimed to provide a broad overview of quality control standar ds, pharmacology, clinical usage, patented & market ed formulations and global trade scenario for Senna an d its products.
Evaluation of various marketed formulations of senna by RP-HPLC and HPTLC
Journal of Pharmacognosy and Phytochemistry, 2019
In the present study, an optimized RP-HPLC and HPTLC validated methods was established for quantification of Sennosides, the major constituents of present in selected five marketed Senna herbal formulation with a simple and accuracy. It also carried out dissolution study on Senna herbal tablets and capsules. Sennosides A and B were determined using the external standard calibration method. The solvent impact on the selectivity factor and partition coefficient parameters evaluated and LOD, LOQ were calculated. The reliability of the HPLC and HPTLC methods for analysis of Sennosides A and B was validated through its linearity, reproducibility, repeatability, and recovery. Fina1ly marked herbal formulation standardized by assay of Sennosides A and B through above HPLC and HPTLC validated method. By above method, determination of Sennosides in Senna herbal formulation carried out and the results suggested that all the five selected herbal formulation posses Sennosides with the limits.
2011
Senna leaves are one of the oldest medicinal herbs and they are used as laxative. Herbal teas which contain senna leaves are most commonly used to promote weight loss. The quality control of slimming teas which contain Senna leaves and also pharmaceutical preparations including Senna extract enriched by sennoside B was achieved by HPLC fingerprinting method. While the presence of sennoside A and B in laxative drugs was proved, it was seen to be devoid of sennosides in slimming teas. Kaempferol 3-O-�-D-gentiobioside (1), aloe-emodine 8-O-�-D-glucopyranoside (2), rhein 8-O-�- D-glucopyranoside (3), torachrysone 8-O-�-D-glucopyranoside ( 4), isorhamnetine 3-O-�-D-gentiobioside (5) were also isolated from Senna leaves.
A Review on Senna and Its Uses
IJCRT - International Journal of Creative Research Thoughts (IJCRT), 2021
Senna is also contain sennosoids which are useful in stimulant laxative and also in constipation. Senna having many types such as, Senna alexandrina, Indian Senna. In this review paper we are known about it is chemical constituents, pharmacological uses, chemical test and it's therapeutic response on constipation etc. The main constituents of Senna are sennosoids and Senna family is legume and subfamily caesalpinioideae. Senna include herbs, shurbs and trees.
IJCRT - International Journal of Creative Research Thoughts (IJCRT), 2021
The senna is a medicinal plants which is a a larger genus of flowering plant in the legume family (Fabaceae). The senna plant is also known as Indian senna, Sennal alexandrina, Diablo Diallobus, Adipera Rat. And EarleacassiaBritton etc. It produces very pretty flower the flower of senna is yellow colour. The senna is contain various types of chemical these chemical constituents are play the vital role in medicinal field. The senna is produces purgative, Catherine, laxative property. It is also used in chronic constipation, irritable bowel syndrome, rectal surgery, hemorrhoids, weight loss and reduction of water absorption.
Formulation, evaluation and stability study of sennoside A & B capsule
The objective of research work was to evaluate and perform stability study of prepared and developed Sennoside A and B capsule. The Sennoside A and B capsule was successfully develop by adding optimum necessary active ingredient and all the prepared formulations were evaluated by different methods such as HPLC and dissolution study Moreover, stability study was performed as per ICH guidelines. All five formulations were identified by chromatogram of HPLC as well as performing dissolution and disintegration study. In addition to, organoleptic qualitative and quantitative evaluation of calcium sennoside was carried by consideration of its pH, loss on drying, tapped density, ash value and its assay. The results obtained in this research work clearly indicated that out of all five formulation, formulation IV significantly increased the frequency and wet weight of stools to 31.5 ± 4.25 and 8.29 ± 1.21 g, and showed tendency to increase the frequency and wet weight of stools. The frequency and the wet weight of stools following gum arabic for 14 days were 16.3±3.98 and 4.79±1.14 g respectively. Key words: Sennoside capsule, Formulation, ICH, Stability study _____________________________________________________________________
Bulletin of Environment, Pharmacology and Life Sciences, 2014
Constipation is a disease caused by various factors and results in the remaining of stools in colons, excessive water absorption by stools, hardening of stools and in case not treated degeneration of neural network inside colons and mega colons and is a common disease in small animals. The purposes of this study after the constipation was induced, it was treated by Senna in one group, Lactulose in another group and placebo in the third one. After a specified period of time, the information was analyzed and the treatment effects of Senna and Lactulose were compared. This Study is a clinical and semi blind trial and was performed on 30 rabbits with the same sex, breed, age and weight. These statistical studies states that lactulose with dose 0.2 ml in respect of per kg body weight was more effective than lactulose with dose 0.1 ml in respect of per kg body weight and placebo, and also state that Senna was more effective than lactulose (p<0.01). Whereas there were not significant statically differences between more or less dose of Senna in respect of treatment duration. These statistical analyses on vital factors showed that dose 18-22 mg of Senna could make significant changes in respiratory rate and blood factors such as PCV, RBC rate, WBC density, full and subtracted count of WBC, Neutrophil and Lymphocytes, in this group as compared with other group.