Evaluation of In-vitro Anti-inflammatory Activity of Aqueous Extract of Andrographis paniculata (original) (raw)
Related papers
Phytochemical and Pharmacological investigation of an indigenous medicinal plant Leucas aspera
Leucas aspera commonly known as 'Thumbai' has a wide variety of medical applications. The aqueous extract of Leucas aspera (leaf extract) was assessed for its various in vitro activities such as anti-inflammatory, anti-helminthic, anti-arthritic, anti-oxidant and anti-bacterial activity. The in vitro Anti-inflammatory activity was studied by human red blood cell (HRBC) membrane stabilization method by using various concentration of L. aspera. The results showed that the HRBC Membrane stabilization activity of the aqueous leaf extract of L. aspera at concentration of 100μg/ml showed 73.25% inhibition of denaturation in hypotonic solution while the standard Diclofenac 100μg/ml showed 79.25% inhibition of denaturation. The crude extracts of the leaves of Leucas aspera showed statistically significant anti-inflammatory activity in in vitro assay.The crude aqueous leaves extract of Leucas aspera also showed that significant anti-helmintic effect causing death of the worm at all the concentrations but the time of death was different in each case. Invitro anti-arthritic activity was carried out by bovine serum protein denaturation method and egg albumin denaturation method. The results suggested that the aqueous extract of L. aspera showed a very good anti-arthritic activity. Antioxidant and Antibacterial activity was also evaluated. The present study concluded that the plant can be formulated in broad spectrum antibiotics and also confirms the traditional uses in pathogenic disease.
The present study was to evaluate the anti-inflammatory activity and their inhibitions way were investigated by Ethyl acetate extract of Cyclea peltata. Initially the phytochemical analysis was performed to identify the bioactive compounds responsible for the inflammatory activity. These plant possessed alkaloid, flavonoid, terpenoid and polyphenols, glycosides. Among the phytochemicals identified flavonoid extract found to have higher anti-inflammatory activity against inflammatory enzymes like cycloxygenase and lipoxygenase. The strategies of in-vitro cycloxygenase and lipoxygenase inhibitory activity were used to evaluate the efficacy of these compounds as anti-inflammatory properties. The Ethyl acetate extracts of Cyclea peltata was studied, effective antibacterial activity by using the disc diffusion method. The Bacteria used for the determination of antibacterial activities were Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Pseudomonas aeruginosa.
Evaluation of Anti-Inflammatory Activity of Macroalgae Collected from Baja California Sur, Mexico
International Journal of Pharmacy and Pharmaceutical Sciences
Objective: This study aimed to establish the anti-inflammatory potential of macroalgae from Baja California Sur, Mexico. Methods: The anti-inflammatory activity of the extracts from 10 macroalgae species was evaluated in vitro and in vivo. Dichloromethane, ethanolic, and aqueous extracts were obtained from each species. The criteria used to determine anti-inflammatory activity included 1) the membrane protection of human red blood cells (HRBCs) against hemolysis induced by hypotonicity, 2) the inhibition of heat-induced protein denaturation (IDP), and 3) the inhibition of mouse ear edema and the myeloperoxidase (MPO) enzyme. Results: The dichloromethane extracts of Gracilaria vermiculophylla and Opuntiella californica were the most active, both in vitro and in vivo. These extracts resulted in values of HRBC membrane protection above 95%, which were similar to those obtained with diclofenac sodium. And reduce the inflammation with edema inhibition percentage up to 60 % while the cont...
Review of Phytochemicals and Pharmacology of Medicinal Plants to Lower Blood Fat Levels
IJPSM, 2021
This review aims to seek information about the phytochemical and pharmacological activities of plants used traditionally to reduce blood lipid levels. The way to find information is to conduct literature studies to find sources or literature in primary data or official books and national and international journals in the last ten years (2010-2020). In doing this review, the search for data using online media with keywords is Phytochemical, Pharmacology, Lowering Blood Fat Levels. Search for the primary references used in this review article's production through trusted websites, namely Google Scholar, Science Direct, NCBI, ResearchGate, and other published and reliable journals. The results show that six herbs are used traditionally to lower blood lipid levels. The six plants contain carbohydrates, tannins, alkaloids, steroids, triterpenoids, flavonoids, glycosides, phenolics, saponins, polyphenols, quercetin, terpenoids, sterol glycosides, flavonols, and formic acid. These six herbs have been shown to work as anti-hypercholesterolemic agents. Thus, it can be concluded that six plants in Indonesia can be developed into phytopharmaca as anti-hypercholesterolemic drugs.
Background: The plant species Aristolochia indica (AI), Melilotus indicus (MI), Tribulus terrestris (TT) and Cuscuta pedicellata (CP) are widely used in folk medicine in the villages around Chowk Azam, South Punjab, Pakistan. The aim of this study was to evaluate the antioxidant activity, phytochemical composition, and the antibacterial, antifungal, cytotoxic and anti-inflammatory potential of the four medicinal plants listed above. For CP stem, this study represents (to the best of our knowledge) the first time phytochemicals have been identified and the antioxidant and anti-inflammatory potential determined.
A Comprehensive Review on Phytopharmacological Activities of Drynaria quercifolia L
Drynaria quercifolia is belongs to the family of Polypodiaceae, is native to tropical areas of Africa, Asia, Australia and Oceania and cultivated mostly as a medicinal plant. It plays an important medical role in many countries, especially in Asia. The plant is used to treat various health problems and is known to have no side effects. Various phytochemicals like 3,4-dihydroxybenzoic acid, friedelin, epifriedelinol, β-amyrin, β-sitosterol and β-sitosterol 3-β-D-glucopyranoside has been isolated from the plant. The rhizome is reported to have anti-fertility, anti-inflammatory and antipyretic, antimicrobial, antioxidant, hepatoprotective, wound healing and antiulcer properties. This review has been designed to provide scientific information regarding phytochemical composition, medicinal uses and pharmacological potentials of Drynaria quercifolia L.
TERPENOIDS AS SOURCE OF ANTI-INFLAMMATORY COMPOUNDS
Terpenoids accounts for the major class of secondary metabolites produced by plants. It shows defense activity against environmental stress and help to heal injuries. Medicinal plants are rich in monoterpenoids, diterpenoids, sesquiterpenes, triterpenes, tetraterpenes, and ceramide. A number of therapeutic applications such as antibacterial, antimicrobial, antitumor, anti-inflammatory activity have been identified. Terpenoids are compounds similar to terpenes derived from 5-carbon monomer isoprene units. The review puts and detail insight on different class of compounds isolated from natural source from 2000 to 2016 showing anti-inflammatory potential of pharmacologically interesting agent and their mechanism of action.