Effect of melatonin versus vitamin D as antioxidant and Hepatoprotective agents in STZ-induced diabetic rats (original) (raw)

2017, Journal of diabetes and metabolic disorders

Diabetes mellitus (DM) is a serious chronic disease, with multiple complications including hepatopathy associated with imbalance of the oxidative status. The purpose of this study is to observe possible protective effects of vitamin-D and melatonin on glucose profile, antioxidant-oxidant status, lipid peroxidation, and histopathological protection of the liver in streptozotocin-induced diabetic rats. Eighty three male albino rats were divided into nine groups as follows:( = 10) Normal control rats;( = 8) were normal rats treated with melatonin only;( = 10) were normal rats treated with vitamin D only;( = 9) were diabetic rats, which received no medications;( = 8) were diabetic rat treated with insulin only;( = 10) were diabetic rats treated with melatonin only;( = 9) were diabetic rats treated with melatonin and insulin;( = 9) were diabetic rats treated with vitamin D only;( = 10) were diabetic rats treated with vitamin D and insulin. Two months post treatment, blood was collected t...

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