Frequency of dementia, depression, and other neuropsychiatric symptoms in 1,449 outpatients with Parkinson’s disease (original) (raw)

Neuropsychiatric symptoms in Parkinson's disease

Movement Disorders, 2009

Neuropsychiatric symptoms are common in Parkinson's disease, even at the earliest stages, and have important consequences for quality of life and daily functioning, are associated with increased carer burden and increased risk for nursing home admission. In addition to cognitive impairment, a wide range of neuropsychiatric symptoms have been reported. In this paper, the epidemiology, clinical course, diagnosis, and management of some of the most common neuropsychiatric symptoms in PD are discussed: depression, anxiety, apathy, fatigue and psychotic symptoms. Although much is known regarding the prevalence and course of these symptoms, the empirical evidence for how to manage these symptoms is limited at best. There is thus an urgent need for systematic studies for the pharmacological and non-pharmacological management of these symptoms.

A comprehensive overview of the neuropsychiatry of Parkinson's disease: A review

Bulletin of the Menninger Clinic, 2017

Parkinson's disease is a widespread neurological illness. However, its psychiatric links have also been discussed lately by many authors, which has brought more depth to the specialized field of neuropsychiatry. Neuropsychiatric complications are commonly seen in Parkinson's patients, including major depression, anxiety, psychosis and hallucination, and cognitive abnormality. Almost all of these complications have a distinct pathophysiology and treatment. In this article we review the most recent studies about the association of these symptoms with Parkinson's disease and highlight the epidemiology, diagnosis, pathophysiology, and treatment of the neuropsychiatric complications, with more emphasis on the pathophysiology of these complications.

Neuropsychiatry of Parkinson's Disease: A Current Overview

Parkinson's disease (PD) may be accompanied by various non-motor symptoms ranging from neuropsychiatric symptoms to autonomic and sensory dysfunctions and sleep disorders, including depression, anxiety, sleep disturbances, psychosis, and behavioural and cognitive changes. Currently, research on PD has ceased to focus exclusively on its motor symptoms, broadening the focus to aspects that are usually affected in the course of the disease and that are very limiting for the patient, such as they are the cognitive, behavioural and functional aspects. The neurobiological bases for the development of neuropsychiatric disorders in PD are increasingly known. For patients and families, these neuropsychiatric conflicts are often more problematic and distressing than the motor aspects of PD. This symptoms often precede typical motor symptoms with consequent importance for early diagnosis and treatment.

Neuropsychiatric Symptoms in an Inpatient Parkinson’s Disease Sample

Parkinson's Disease, 2014

Background. Neuropsychiatric symptoms are common in idiopathic Parkinson’s disease (PD), and hospitalization for delirium, depression, psychosis, and anxiety is sometimes required. A minimal amount of data exists on these patients.Methods. Charts of all patients admitted to a psychiatric hospital between 2006 and 2009 with a diagnosis of PD were reviewed. Forty-three met entry criteria and were reviewed. Initial and discharge diagnoses, comorbid psychiatric diagnoses, length of stay, and living arrangements before and after hospitalization are described.Results. Consistent with previous research, this study showed evidence of comorbid psychiatric disorders within PD.Conclusions. The long-term goal of this area of study would be to reduce neuropsychiatric symptoms and improve quality of life in order to reduce inpatient hospital stays.

Neuropsychiatric Aspects of Parkinson’s Disease

Psychosomatics, 2000

Parkinson's disease (PD), a disorder characterized by movement abnormalities, is frequently complicated by psychiatric syndromes. Psychiatric assessment of the PD patient requires familiarity with the motor and cognitive aspects of PD, the various effects of antiparkinsonian medications, and how these relate to mental status changes and psychiatric phenomena. This review describes the various motor and nonmotor features of PD and focuses on the differential diagnosis of affective disorders in PD and their treatment.

Managing the neuropsychiatric symptoms of Parkinson's disease

Neurology, 1998

Article abstract-Neuropsychiatric symptoms frequently complicate the treatment of Parkinson's disease (PD). Approximately 27% of PD patients are demented, and approximately 19% are cognitively impaired without being demented. These 46% of patients are prone to development of delirium when they take antiparkinsonian drugs. Approximately 40% of PD patients are depressed. The depression may be endogenous or exogenous, apathetic or agitated. Approximately 40% of PD patients are anxious or have panic attacks. The attacks may or may not be associated with depression. This article reviews the diagnosis of these symptoms and discusses their management.