Drug-Drug Interaction Studies of Levocetirizine with Atenolol (original) (raw)
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In-vitro Comparative Dissolution Study of Different Brands of Levocetirizine
International Journal of Innovation and Applied Studies, 2019
Branded drugs are more expensive than locally marketed drugs. The aim of this present study was to evaluate and compare dissolution pattern of locally branded drug products of Levocetirizine dihydrochloride of regional pharmaceutical companies available in Bangladesh with the reputed brand of Levocetirizine 2HCl (Purotrol®) marketed by Square pharmaceuticals Ltd. Four different brands of Levocetirizine 2HCl tablets and Purotrol® were collected from a reputed pharmacy store, then evaluated and compared subsequently. Five tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 30 minutes for all the brands. Differential factor, f1 and similarity factor, f2 were determined. Significant difference was observed for in-vitro drug release pattern of local brands with respect to Purotrol®. Here it was found that the values of f1 are 25.11, 26.08 and 15.52 for brand B, C, and D respectively so it is not acceptable. Only brand A...
Indian journal of pharmaceutical sciences, 2011
A simple, sensitive and reproducible method was developed and validated for the simultaneous estimation of diethylcarbamazine and levocetirizine in its tablet formulation by reverse phase high performance liquid chromatography using Waters1515 HPLC with UV detector at the λ(max) of 224 nm, using Princeton Sphere-100 C(18) (250×4.6 mm. 5 μ) column. The mobile phase used was 20mM potassium dihydrogen orthophosphate buffer (pH: 3.2):acetonitrile (50:50 v/v) with isocratic flow (flow rate 1 ml/min) and the pH was adjusted with orthophosphoric acid. Losartan potassium was used as an internal standard. The compounds diethylcarbamazine, levocetirizine and losartan potassium were eluted at 2.12, 4.27 and 5.96 min, respectively. The peaks were eluted with better resolution. The method was accurate with assay values of 96.32 and 93.04% w/w, precise (%RSD) with intra-day 1.72 and 1.89 and inter-day 1.85 and 1.92, recoveries 102.86 and 101.1% w/w, which are very sensitive with limit of detectio...
2012
The present work deals with development and validation for simultaneous determination of antihistaminic drugs in pharmaceutical formulations. A rapid, precise and specific high performance liquid chromatography (RP-HPLC) method was developed for Levocetirizine dihydrochloride and Phenylephrine. Chromatographic separations was achieved on Waters Younglin system C-18 (5μm, 250×4.6 mm) HPLC column within a short runtime of 10 min. HPLC system having isocratic mode, with mobile phase containing methanol : water (pH 3) (70:30% v/v) and flow rate maintained at 1.0 mL/min was used. Effluents were monitored at 230 nm. Retention time of Levocetirizine dihydrochloride and Phenylephrine were found to be 2.6 and 4.6 min respectively. Linearity was studied in the concentration range of 2 to 12 μg/mL and 12 to 72 μg/ mL for Levocetirizine dihydrochloride and Phenylephrine respectively, with a correlation coefficient of 0.998 and 0.999 respectively. The proposed method was validated according to t...
2015
Four simple and accurate spectrophotometric methods have been described for the simultaneous determination of levocetirizine dihydrochloride and montelukast sodium in tablet dosage form. The first method is a bivariate calibration algorithm involving the use of two selected wavelengths 220 nm and 230 nm for the determination of studied drugs. The second method is a dual wavelength which is based on determination of levocetirizine dihydrochloride at the absorbance difference between 208 nm and 214.4 nm in which montelukast sodium absorbance difference was zero for any concentration, also montelukast sodium can be determined at absorbance difference between 355 and 390 nm in which levocetirizine dihydrochloride has absorbance zero for any concentration also. The third method is a derivative spectrophotometry, in which the two drugs were quantified using second derivative responses at 244 nm for levocetirizine dihydrochloride and at 293.2 or 335.6 nm for montelukast sodium. The fourth ...
Scientia pharmaceutica, 2012
A fast-dissolving film containing levocetirizine, a non-sedative antihistamine drug, was developed using pullulan, xanthan gum, propylene glycol, and tween 80 as the base materials. The drug content of the prepared films was within an acceptable limit as prescribed by the USP. The film exhibited excellent stability for four months when stored at 40 °C and 75% humidity. In vitro dissolution studies suggested a rapid disintegration, in which most of levocetirizine (93.54 ± 3.9%) dissolved within 90 seconds after insertion into the medium. Subsequently, Sprague-Dawley rats were used to compare the pharmacokinetic properties of the film preparation administered to the oral cavity, to those with oral administration of the pure drug solution. The pharmacokinetic parameters were similar between the two groups in which AUC(0-t) (ng h/ml), AUC(0-∞) (ng h/ml) C(max) (ng/ml), T(max) (min), K(el) (h(-1)), and t(1/2) (h) of the reference were 452.033 ± 43.68, 465.78 ± 48.16, 237.16 ± 19.87, 30, ...
Drug interactions in gastrointestinal disorders therapy
Romanian Journal of Pharmaceutical Practice
Drug-drug interactions are a major cause of adverse reactions in polypharmacy, the incidence being directly proportional to the number of associated drugs. In this work, we highlighted the main drug-drug interactions that occurred in the treatment of gastrointestinal symptoms with proton pump inhibitors and histamine H2-receptor antagonists. The two groups of agents, used in gastroesophageal reflux and ulcer disease, can be released and without a prescription on the recommendation of the pharmacist, contributing to the risk of emergence of drug-drug interactions. Drug-drug interactions can occur due to the reduction of the gastric acidity, altering the biotransformation or excretion reducing of the drug co-administrated. pH increased may affect the absorption of some drugs decreasing (e.g. ketoconazole, itraconazole, atazanavir, vitamin B12, magnesium) or increasing the absorption of others (e.g. triazolam, midazolam). Furthermore, an attention to the interaction with narrow therape...