Epidemiological features of Central Nervous System tumors at MAHAK Pediatric Cancer Treatment and Research Center (original) (raw)
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Pediatric Central nervous system tumors, single institutional experience
Mosul Journal of Nursing
Objectives: The characteristics of 144 Iraqi children with primary CNS tumors were reviewed to identify median age at presentation, the disease distribution in terms of gender, main presenting symptoms, most common grade and histological subtypes, with predominant subsites in which central nervous system malignancies arise from, according to WHO 2016 classification. Patients and methods: Medical records were used to collect data on primary CNS malignancies in children under the age of 18 years, in a single tertiary center in Kurdistan/Iraq, Zhianawa cancer center, the study time period was from March 2009 to December 2021 (12 years period study). We classified age into 5 subgroups: (Infancy) less than 1, 1-4 years old, 5-9 years old, 10-14 years old and above 15. Results: The study showed that, males were more frequently affected than females, median age at diagnosis was 8.7 years old, predominate age group was (5-9) %38, followed by (10-14) 24.3%. Medulloblastoma which is grade IV tumor was the most common histopathology subtype in 30% of the cases, followed by Astrocytoma and Brain stem glioma as the 2nd and 3rd histopathology. Infratentorial location was the most common involved location in central nervous system (57.6%), followed by supratentorial (40.3%), spinal cord (%2.08) only. Conclusion: Pediatric CNS tumors in this study have specific characteristics when compared to those seen elsewhere in the world. Grade IV and infratentorial location for example, are the most common in our children.
Comprehensive analysis of Iranian reports of pediatric central nervous system tumors
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2017
Iran lacks a national registry reporting the data of central nervous system (CNS) tumors in children. Consequently, treatment success and failure rates are unknown, and a centralized system for disease-management recommendations does not exist. To critically evaluate the current state of pediatric CNS tumor studies and reporting in Iran, we performed an extensive retrospective analysis of all known reports identified with multiple search engines. Of 409 initially retrieved articles, we evaluated 123 matching our inclusion criteria. We further narrowed these reports to 74 by excluding studies pertaining to adult patients only, non-CNS tumors, or brain metastases. We also excluded studies that were performed outside of Iran or that did not contain relevant data from our analysis. We divided the remaining studies into those describing exclusively pediatric patients (3484 patients) and those describing mixed populations of adults and children (18,641 patients). In total, our analysis in...
2021
Objective: To analyze the histological spectrum of pediatric brain tumors (PBT) in Pakistani population and to compare the results with international data. Study Design: Retrospective observational study. Place and Duration of Study: Armed Forces Institute of Pathology, Rawalpindi, from Jan 2015 and Dec 2019. Methodology: This data was analyzed using the latest World Health Organization (WHO) classification of Tumors of Central Nervous System 2016. The cases were divided in 5 categories according to age (0-2, 3-5, 6-8, 9-11 & 12-14 years). Results: A total of 43 cases were included in the study. Of these cases, 26 (60.46%) were male and 17 (39.5%) were female. Male to female ratio was 1.5-1. The 6-8 year age group had the highest number of tumors while 0-2 year age group had the least. Mean age of diagnosis was 7.6 years. Ependymoma wasthe most common morphological type with 12 cases (28%) followed by pilocytic astrocytoma, diffuse glioma with 10 cases each (23%) and medulloblastoma...
Middle East Journal of Cancer, 2018
Background: Treatment of childhood brain tumours requires coordinated efforts by multiple specialities-neurosurgery, neuroradiology, neuropathology, oncology, and radiotherapy. The outcome is worse in developing countries compared to developed countries because of deficiencies in proper registry, failure of timely diagnosis, lack of availability and coordination of multiple specialists required for comprehensive management and high abandonment rates. Method: The pediatric neuro-oncology program was initiated in collaboration with the neighbouring neurosurgery institution as a step towards improving care for pediatric brain tumor patients in our hospital. Epidemiology, treatment and followup of brain tumours in children aged 1-14 years attending the pediatric oncology department were studied. Patients received multimodality treatment with surgery, radiotherapy and chemotherapy by specialists in both centres. The study period was from January 2008 to December 2012. Results: There were 375 pediatric brain tumour patients during the study period. 166 patients (44.2%) had supratentorial tumors and 209 (55.73%) had infratentorial tumors. 42.6% of tumours were high-grade and 53.6% were low grade. The commonest histopathological tumour type was astrocytoma (48.8%) followed by medullobastoma (24.5%). 287 (76.5%) patients underwent surgery, 216 (57.6%) patients received radiotherapy, 97 (25.8%) patients received chemotherapy and 94 (25%) required follow-up only. Patient follow-up rates improved from 37.2% to 82.6% and treatment abandonment decreased from 35.8% to 14.8% over these years. Conclusions: Impact of the pediatric neuro-oncology program in our hospital has made it possible to provide comprehensive multidisciplinary treatment in a coordinated manner, describe the epidemiology of pediatric brain tumors, reduce treatment abandonment, and improve the follow-up of pediatric brain tumour patients.
Pediatric Tumors Of Central Nervous System CNS An Epidemiopatho logic Research Study
Background: Pediatric tumors of central nervous system (CNS) are 2 nd most common tumors after Leukemia in children. Presentation of pediatric CNS tumors is different from adult CNS tumors. There is a diverse distribution of these tumors in children when compared to tumors in adults. Till today there are a very few published databases regarding the epidemiological profile of Pediatric CNS tumors in our country. Aim: To sketch the epidemiological picture of pediatric CNS tumors (<15 years) Objectives: To determine the incidence, age, sex, location, histopathologicalvariants and subtypesof pediatric CNS tumors and map the data with other epidemiological studies. Materials and methods: A review of 148 medical records diagnosed as CNS tumors was carriedout in various government and private hospitals in central and southern regions of Andhra Pradesh. Amongst which 50 (33.7%) cases werepediatric CNS tumors. A broad discriminativeretrospective study was done for a period of 3 years (2008)(2009)(2010)(2011). Results: During the 3 years of the study period, 148 CNS tumors were noted in which 50 (33.7%) werepediatric CNS tumors. 48(96%) were intracranialand 2(4%) were intraspinaltumors. 36(72%) were male and 14(28%) were female. M:F ratio was 2.57:1. Thus, evident male predominance was observed. Majorityof cases were observedin age groupof 11-15 years and maximum number of cases was seen in individuals of 12 years old. The mean age at diagnosis was 9.02 and median agewas 9±4.07 years. 38(75%) were infratentorialand 12(25%) were supratentorialtumors. Astrocytomawas the most common tumor -16(32%) cases. Among Astrocytoma -Pilocytic Astrocytoma was the common tumor -8(50%) cases. Conclusion: Pediatric CNS tumors constitute a varied group with respect to incidence, distribution, anatomical location, histopathologicalvariants and subtypes. Thus, it is necessary to formulate separate lines of investigations and management aspects for different tumors in children for better care, treatment and prognostic evaluation.
2018
Objective: To evaluate distribution, initial clinical presentation and survival rate of children with central nervous system tumors treated in a capital city of Northeast, Brazil. Method: This is a prospective study, which includes patients aged under 19 years admitted between July/2011 and July/2013. Results: The approximate mean annual incidence of pediatric CNS tumors in Sergipe was 22.4 cases per 1,000,000 children and adolescents per year. The mean age was 7.68 years, 67.6% were female and 76.5% non-whites. In 79.4%, headache and vomiting were present at first clinical evaluation, in the majority associate with neurological deficits. The cerebellum was the most affected anatomic structure (32.4%). The infratentorial compartment was compromised in 50% of cases. Associated morbidities were more frequent in the supratentorial compartment (p = 0.015) and the most frequent histological types were pilocytic astrocytoma (23.5%), diffuse intrinsic pontine glioma (17.6%) and 11,8% medul...
Asian Australasian Neuro and Health Science Journal (AANHS-J)
Brain tumors are the most common disease group of solid tumors in childhood, and children with brain tumors have a relatively poor survival rate. Epidemiologic data from a hospital-based registry provide the necessary information to obtain a full picture of the frequency of this disease, which is a great challenge in pediatric oncology. One hundred thirty four tumors in children between 0 and 17 years of age diagnosed between 2013 to 2017 were classified according the sex, and topography. Incidence of brain tumor in boys were higher than girls. From the registry data, the prevalence for boys was higher (67%). In the whole series, 54% were supratentorial, 46% infratentorial. The most common histopathologic pattern seen in the registry were pilocytic astrocytoma which accounts for 42 cases (31%) followed by medulloblastoma and craniopharygioma with the percentage of 25% and 18% respectively. The least histopathologic pattern of pediatric tumor seen in our center are diffuse astrocytom...
IP innovative publication pvt. ltd, 2019
Paediatric brain tumours are the most common solid tumours in children and hence, leading cause of mortality and morbidity in children in our country. Though we have enough statistical data about its epidemiology in western population, there are only a few reports from developing countries like India. Aims: To study the epidemiological patterns of brain tumours in children in our institute. Materials and Methods: It is a medical record based observational study in which retrospective epidemiological approach is used. The records of 50 children <18 years registered in our department suffering from primary brain malignancy over a period of one year are selected. Data regarding age, sex, site of the tumour, clinical features, histology and immunohistochemistry are collected. The World Health Organization classification 2016 of neoplasms is adopted. Results: Male patients falling under the age group of 6-10 years is the most common age group in which these tumours are diagnosed. The most common primary paediatric brain tumours were astrocytic tumours (28%), followed by medulloblastoma (26%) and ependymoma (16%). The most common astrocytic tumour was pilocytic astrocytoma. Conclusion: Our study is an attempt to analyse the epidemiological pattern of paediatric CNS tumours in premiere tertiary care cancer institute of western India which showed the histological profile of paediatric brain tumours in India is like that reported in the Western literature.
Annals of Pathology and Laboratory Medicine, 2016
Background: The primary pediatric brain tumors (PBT) are the second most common cause of death due to malignancies in children. This study was done to analyze the histological spectrum of primary brain tumors in children and also to find out the epidemiology of the common pediatric brain tumors. Methods: Data regarding age, gender, topography, and histopathology of 239 pediatric patients (0–18 years) with brain tumors operated over a period of 15 years (January-2001 to December-2015) was collected and analyzed according to World Health Organization 2007 classification Result: PBTs were more common in males (54.8%) as compared to females (45.2%) with male to female ratio of 1.21:1. Frequency of tumors was higher in childhood age group (>5-<15 years) i.e. (55.6%) when compared to adolescent age group (15.9%). The most common anatomical site was cerebellum (40.5%), followed by hemispheres (21.4%). Supratentorial tumors (51.9%) were predominant than infratentorial tumors (45.2%) a...