Comparative effects of graded doses of diaminanzine ace-turate and fixed doses of levamisole in the treatment of albino mice experimentally infected with Trypanosoma brucei brucei (original) (raw)

Journal of Experimental and Applied Animal Sciences

Trypanosomosis is a widespread and important disease of animals and humans in tsetse-infested areas of Africa, Nigeria inclusive. To investigate the comparative effects of graded doses of Diaminazine aceturate (DA) and fixed doses of Levamisole in the treatment of albino mice experimentally infected with field isolates of Trypanosoma brucei brucei. Thirty adult mice were used and were randomly divided into 6 groups of 5 mice each. After infection has been established, 3 groups (A, B and C) were treated with graded doses of DA at 7, 14 and 21mg/kg body weight respectively and a fixed dose of Levamisole at 7.5mg/kg body weight, whereas group D was treated with Levamisole only at the same dose. Group E served as positive (infected untreated) control while group F served a negative (uninfected untreated) control. The following parameters were used to access the efficacy of the drugs: weekly rectal temperature, weight changes, packed cell volume, haemoglobin concentration, clinical sign...

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