Prospective evaluation in 123 patients of strain ratio as provided by quantitative elastosonography and multiparametric ultrasound evaluation (ultrasound score) for the characterisation of thyroid nodules (original) (raw)
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Thyroid Nodules Evaluation by Strain Ultrasound Elastography and Histocytological Correlation
SRMS Journal of Medical Science, 2016
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International Journal of Research in Medical Sciences
Background: Elastography is a method recently being used in the evaluation of thyroid nodules by comparing tissue elasticity. Strain and shear wave elastography are two types of elastography still being used in clinical practice. Two kinds of elasticity can be assessed by strain elastography. First, colors around and within the nodules are evaluated and visually scored according to the 4-5 scale scoring systems. The aim of this study was to determine the diagnostic accuracy of strain ultrasound elastography in differentiation between benign and malignant thyroid nodules, taking histopathology as gold standardMethods: Total of 101 patients with palpable thyroid nodule of any size of age 30-70 years of either gender were included. Patients with previous thyroid surgery and already proven histopathology were excluded. Strain ultrasound elastography was performed in every patient by using a highresolution unit with a linear array probe centred at 7.5 MHz. Strain ultrasound elastography ...
Role of Elastography in Ultrasound Evaluation of Thyroid Nodules
2017
Background: Ultrasound is the modality of choice for evaluation of thyroid nodules. Elastography plays a complimentary role in characterizing the thyroid nodules. Objectives: This study is undertaken to evaluate the role of Elastography in evaluation and characterization of the thyroid nodules. Materials and methods: Fifty cases of thyroid nodules who underwent ultrasound evaluation during March 2016 to march 2017 were included in the study. Elastography was performed during the same sitting. Ultrasound guided FNAC was performed for cytological correlation. Results: Out of the 50 patients 80% were females and 20% were males. Forty two cases were benign on FNAC and 35 of these were seen in females. Eight cases were malignant nodules. Out of the eight cases which were diagnosed as malignant, marked hypo-echogenicity, micro-calcification, intrinsic vascularity and elastography features were found to be useful in differentiating benign from malignant lesions. The sensitivity and specifi...
Pakistan Journal of Medical and Health Sciences, 2022
Background: Elastography is a method recently being used in the evaluation of thyroid nodules by comparing tissue elasticity. The aim of this study was to determine the diagnostic accuracy of elastography in differentiation between benign and malignant thyroid nodules, taking histopathology as gold standard. Methods: Total of 50 patients with palpable thyroid nodule of any size of age 20-60 years of either gender were included. elastography was performed in every patient by using a high resolution unit with a linear array probe centered at 7.5 MHz, elastography was performed in every patient by a consultant radiologist benign or malignant thyroid nodules was noted. Elastography findings were compared with histopathology report Results: All the patients were subjected to strain ultrasound elastography. USG supported the diagnosis of malignant thyroid nodules in all 50 patients. Histopathology confirmed malignant thyroid nodules in 46 (true positive) cases where as 4 (false positive) had no malignant lesion on histopathology. In USG negative patients, 47 were true negative while 2 were false negative. Overall sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of strain ultrasound elastography in differentiation between benign and malignant thyroid nodules, taking histopathology as gold standard is 90.0%, 90.30%, 92.31%, 94.77% and 93.18% respectively Conclusion: According to this study, strain ultrasound elastography is the non-invasive modality of choice with high diagnostic accuracy in diagnosing malignant thyroid nodules.
Role of Ultrasound Elastography in Prediction of Malignancy in Thyroid Nodules
Endocrine Research, 2012
Background. Ultrasonography is considered useful to distinguish between solid and cystic thyroid nodules and to stratify a nodule's risk of cancer as low, medium, or high. Ultrasound (US) elastography has been applied to study the hardness/elasticity of nodules to differentiate malignant from benign lesions. Elastography possibly can solve the dilemma in reaching an accurate diagnosis for the cytologically known as indeterminate nodules. Aim. To evaluate the sensitivity and specificity of US elastography in the diagnosis of thyroid cancer. Patients and methods. This prospective study included 40 patients. The total number of nodules was 46, they were all euthyroid. Laboratory investigations were done including FT 3 , FT 4 , and TSH to exclude hot nodules. Neck US, US elastography, and fine-needle aspiration were done to all patients, and US elastography scoring system from 1 to 4 was used. Results. Four out of the 46 studied nodules were malignant. The ROC curve for elastography score (E-score) showed high sensitivity, specificity for the diagnosis of malignant thyroid nodules with a cut-off value of E-score 4 and high significance (p < 0.001), the area under curve was 0.92. The sensitivity was 75.0% and specificity was 100%. For E-score more than 2, the sensitivity was 100% and specificity was 85.37%. Conclusion. US elastography can be used to increase both the sensitivity and the specificity of US for the detection of malignant thyroid nodules, and so it seems to have great potential as a new tool for the diagnosis of thyroid cancer.
The value of ultrasound elastography in differentiation of malignancy in thyroid nodules
Clinical Imaging, 2014
We aimed to determine the value of ultrasound elastography (US-E) using carotid artery pulsation in differentiation of malignant and benign thyroid nodules. One hundred ten nodules were evaluated by US-E, and stiffness scores were compared to biopsy results. When cutoff for malignancy was determined as score 4, sensitivity, specificity, positive predictive value, and negative predictive value were 100%, 95%, 40%, and 100%, respectively. We suggest fine needle aspiration biopsy to be performed in all score 4 nodules, while biopsy may be unnecessary in score 1 nodules. Benign biopsy result in a score 4 nodule should suggest radiologicalpathological disagreement, and repeat biopsy should be recommended.
The efficiency of US elastography in the differential diagnosis of thyroid nodules
Journal of the Belgian Society of Radiology, 2015
To evaluate the efficiency of ultrasound elastography (Use) in the differential diagnosis of thyroid nodules. Methods: one hundred thyroid nodules in 100 patients (79 females, 21 males, age range 18-78; mean age = 45.6 years) were evaluated with real-time freehand Use, using hitachi eUB 7500 equipment and elasticity scores were obtained. The elasticity was scored as follows: score 1, elasticity in the entire nodule; score 2, mainly elastic nodule with the presence of inelastic areas not constant during real time examination; score 3, constant inelastic areas prevalently arranged at the periphery of the nodule; score 4, constant inelastic areas prevalently arranged at the center of the nodule; score 5, no elasticity in the nodule. also mean strain ratio values were calculated for all nodules. Results: eighty-four (86%) of cases were benign and sixteen (16%) were malignant. elasticity score 3 and higher and strain ratio higher than 2.485 had statistically significant relation with malignancy (p < 0.05). Conclusions: Use including strain ratio calculations besides subjective evaluation of elasticity scores is an efficient imaging method which may contribute to the differential diagnosis of thyroid nodules.
Elastography as predictor for thyroid nodule malignancy
World Family Medicine Journal /Middle East Journal of Family Medicine
Background: Ultrasound elastography is a promising noninvasive technique that is still in its infancy. It uses tissue elasticity measurements to distinguish between benign (soft tissues) and malignant (hard tissues) nodules. Objectives: to see if elastography has diagnostic significance and if it may be used as a predictor of thyroid nodule malignancy Methods: An analytical cross-sectional study was done and data collected using Philips Epiq 7 linear transducer 8-12MHZ, strain type of elastography. A sample of 27 patients from Al-Hada Armed Forces Hospital, Taif, Saudi Arabia were included. Data about patients’ demographics, AP, TR, Echogenicity, Margin, Composition, Echogenic foci, FNA result, Elastography findings and TIRADs classification were collected. Results: According to FINA findings, the majority of patients (96.3 percent) had a benign tumour, and 81.5 percent had soft elastography. T2 was the most common TIRADs classification (55.6 percent). The percentage of patients wit...
IIUM Medical Journal Malaysia
INTRODUCTION: Ultrasound has been widely used to assess thyroid nodules. Although ultrasound elastography has been developed to improve detection of thyroid malignancy, it has received mixed responses. This study aimed to determine the efficacy of ultrasound elastography in detecting malignant thyroid nodules. MATERIALS AND METHODS: Patients with thyroid nodules were assessed using conventional ultrasound and elastography followed by fine-needle aspiration and or hemithyroidectomy. The ultrasound findings were compared with the cytology or histopathology for statistical analysis. RESULTS: Out of 156 nodules from 92 patients included in the study, 12 (7.7%) were malignant and 144 (88.8%) were benign. The elastography was found to be an independent predictor of malignancy (OR 10.35, 95% CI [1.31, 81.6], p = 0.03). Other independent predictors were taller shape and central Doppler pattern obtained using conventional ultrasound. A combination of the three independent predictors was show...
Elastography in the Differential Diagnosis of Thyroid Nodules
Ultrasonic Imaging, 2014
Despite the publication of a recent meta-analysis of elastography in thyroid nodules, further work is necessary on this issue in different populations. In this study, we aimed to evaluate the clinical value of elastography on nodular goiters in mild iodine-deficient regions without excluding patients according to nodule characteristics. This prospective study was conducted between April 2010 and December 2011 in Yıldırım Beyazıt Dıskapı Research Hospital Endocrinology outpatient clinic. Five hundred twenty-eight nodular goiter patients who underwent thyroid fine-needle aspiration biopsy were included in our study. Elastography scores and indexes were measured with real-time ultrasound elastography (Hitachi® EUB 7000 HV machine with 13 MHz linear transducer). There were 471 females and 57 males and their ages ranged from 45 years to 78 years. A total of 601 nodules were evaluated in these patients. The area under the curve (AUC) for the elasto score was 0.91 ( p < 0.0001) and AUC ...