Is There an Association Between the Familial Form of Generalized Joint Hypermobility and Developmental Dysplasia of the Hip in Children (original) (raw)

Background and objectives This study aimed to examine the association between the familial Generalized Joint Hypermobility (GJH) and Developmental Dysplasia of the Hip (DDH) in children. Methods All the infants and children included in this case (with DDH) – control study, were examined for features of GJH by the revised Beighton’s Test Scale (BTS) provided that they had no teratogenic or pathological causes of DDH or GJH. Results Two hundred and eight participants were included in this study, 101 (48.6%) cases, 107 (51.4%) controls; age mean 16.57 (Standard Deviation ‘SD’ 18.1) months; 61.1% (127) females and 38.9% (81) males. The Odds Ratio (OR) was 2.1 (95% Confidence Interval 1.197 – 3.679). The cases had a higher value of BTS’s score (mean = 4.7, SD = 3.015) compared to the controls (mean = 3.42, SD = 3.448). The difference was statistically significant but the Correlation Coefficient (r) between the study groups and BTS’s scores was weak (r = 0.194, P = 0.005). The correlation gained slight improvement by justification of the age to obtain homogeneity between the groups (r = 0.276, P < 0.001), but deteriorate and lost its significance when the sex was controlled as a confounder (r = 0.121, P = 0.082). There was a gradual increase of the mean BTS’s score from grade one to grade four of DDH but without a statistically significant value (r = 0,132, P = 0.128). Conclusion The familial GJH has a weak - positive - correlation with DDH but can’t be considered as a possible risk factor for it.

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