Targeting amyloid precursor protein shuttling and processing - long before amyloid beta formation (original) (raw)

This perspective discusses a shift in Alzheimer's disease (AD) research from targeting amyloid beta (Aβ) plaques to earlier stages of Aβ production, focusing on amyloid precursor protein (APP) shuttling and processing. Emphasis is placed on understanding the mechanisms of APP processing through different secretases and identifying potential therapeutic targets that can inhibit the amyloidogenic pathway. The conclusion highlights the promise of novel therapeutics targeting APP processing while noting the existing gaps in understanding the overall role of APP and Aβ in neurobiology.