IMMUNOLOGY: One AID to Unite Them All (original) (raw)

Science, 2002

Abstract

By creating an extremely diverse antibody repertoire, B cells protect the body against numerous infectious pathogens. Generation of this antibody repertoire depends on immunoglobulin gene modification events driven by four different molecular processes: V(D)J recombination, somatic hypermutation, class switch recombination, and gene conversion. The enzyme AID (activation-induced cytidine deaminase) is known to be involved in somatic hypermutation and class switch recombination. In their Perspective, [Fugmann and Schatz][1] explain that AID is also essential for gene conversion ([ Arakawa et al .][2]) and discuss how AID could operate in these three quite different processes. [1]: http://www.sciencemag.org/cgi/content/full/295/5558/1244 [2]: http://www.sciencemag.org/cgi/content/short/295/5558/1301

David Schatz hasn't uploaded this paper.

Let David know you want this paper to be uploaded.

Ask for this paper to be uploaded.