Impact of the epithelial dysplasia grading and Ki67 proliferation index in the adjacent non-malignant mucosa on recurrence and survival in head and neck squamous cell carcinoma (original) (raw)
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British journal of cancer, 1996
The prognostic weight of histological and biological factors was compared with that of known clinical prognostic factors in a population of 108 consecutive previously untreated patients with head and neck squamous cell carcinoma. Parameters studied were: tumour vascularisation, mitotic index, histological differentiation, nuclear grade, keratinisation, desmoplasia, growth pattern, inflammation, tumour emboli in peripheral vessels, keratins 6, 13, 19 immunohistochemical expression, cytofluorometric ploidy and S-phase. In multivariate analysis (Cox), only age and nodal status had a significant impact on the overall survival, whereas T stage was the only significant factor associated with locoregional failure. The cumulative incidence of metastases was correlated not only with age, T and N stage, but also with histological differentiation. All the other histological and biological factors studied failed to provide further prognostic information. These findings may help to select patien...
BMJ Open
ObjectivesTreatment failure and poor 5-year survival in mucosal head and neck squamous cell carcinoma (HNSCC) has remained unchanged for decades mainly due to advanced stage of presentation and high rates of recurrence. Incomplete surgical removal of the tumour, attributed to lack of reliable methods to delineate the surgical margins, is a major cause of disease recurrence. The predictability of recurrence using immunohistochemistry (IHC) to delineate surgical margins (PRISM) in mucosal HNSCC study aims to redefine margin status by identifying the true extent of the tumour at the molecular level by performing IHC with molecular markers, eukaryotic initiation factor, eIF4Eand tumour suppressor gene, p53, on the surgical margins and test the use of Lugol’s iodine and fluorescence visualisation prior to the wide local excision. This article describes the study protocol at its pre - results stage.Methods and analysisPRISM-HNSCC is a bilateral observational research being conducted in Da...
Correlation between T and N Stages of Head and Neck Squamous Cell Carcinoma
Journal of College of Medical Sciences-Nepal, 2015
Background and Objective: Squamous cell carcinoma of the head and neck region is a common pathological entity. Advanced primary lesion (T) and neck node metastasis (N) both are bad prognostic features for the carcinoma. Purpose of this prospective cross sectional study is to see if T stage of primary Head and Neck squamous cell carcinoma correlates with N stage of Neck node metastasis.Materials and Methods: Patients of all ages and both sex with biopsy proven squamous cell carcinoma of Head and Neck region were included in the study. After detailed history taking and clinical examination to identify the clinical T and N status of the disease, biopsy was taken from the primary site under local or general anesthesia. Fine Needle Aspiration Cytology (FNAC) of the palpable neck node (s) was performed. Correlation of T stage of the primary tumor was seen with that of N stage of the neck by applying the statistical tests.Results: There was significant correlation of the T status of the pr...
Journal of Clinical Medicine, 2021
Background: squamous cell carcinoma (SCC) is the second most common type of malignancy worldwide. Skin and mucosa of the head and neck areas are the most frequently affected. An aggressive behavior in SCC is not easily detected, and despite all efforts, mortality in these types of cancer did not show major improvements during recent decades. In this study, we aim to determine the role of histological features available through standard pathology assessment in SCC and their relation with tumor behavior and patients’ survival. Method: in a group of one hundred patients diagnosed with SCC involving the head and neck areas, we assessed the presence of four histological features (tumor/stroma ratio, immune infiltration at the front of invasion, tumor-budding activity, and tumor necrosis), their correlations with tumor type (mucosal or cutaneous), tumor clinicopathological characteristics, and their prognostic potential. Results: the comparison between histological features in cutaneous v...
Head and neck squamous cell carcinoma : Mansoura 10 years experience
2005
Head and neck (H&N) cancers are the sixth most prevalent cancers in the world with squamous cell carcinoma (SCC) constituting around 90% of it. One hundred and eighty eight patients with H&N SCC were treated at Mansoura University Hospital in the period from January 1990 to December 1999 inclusive. For those 188 cases we analyzed their clinicoepidemiologic data, survival, prognostic factors, patterns of failure and toxicity of therapy. Unfortunately 75.5% of the cases presented in advanced stages. The median eventfree survival duration was 14 months, while the median overall survival duration was 22 months. The 5-year eventfree survival and overall survival were 45% and 53%, respectively. On multivariate analysis for event-free survival, only performance status and grade were significant (p ≤0.05). On the other hand multivariate analysis for overall survival found only performance status and stage to be significant (p ≤0.05). Local failure exceeded in incidence both nodal and distan...
Prognostic factors in head and neck cancer: Histologic grading, dna ploidy, and nodal status
Head & Neck, 1991
Histopathologic malignancy score and DNA ploidy were investigated as prognostic factors for 72 cases of squamous cell carcinoma of the head and neck (HNSCC). The malignancy grading was based upon four different morphologic characteristics for the tumor cell population and four characteristics for the tumorhost relationship. DNA ploidy was determined through flow cytometry on fresh-frozen tumor samples. The median malignancy score was 20, with 71% of the tumors scoring < 20 being diploid and 68% of the tumors scoring ? 20 being nondiploid (p = 0.003). Univariate analysis revealed that tumors scoring < 20 and diploid tumors had a significantly higher proportion of complete response and better survival as compared to tumors scoring ? 20 and nondiploid tumors, respectively. There was a tendency toward better survival among patients without regional metastasis (NO) as compared with patients with regional spread (N+), whereas the other single factors, patient age, clinical From Departments of Oto-rhino-laryngology (Drs. ZBtterstrOm and Wennerberg), Oncology (Dr. Ewers), and Pathology (Dr. WillBn) and Southern Swedish Regional Tumor Registry (Ms. Attewell), University Hospital of Lund, Lund. Sweden.
A New Approach to Survival Analysis of Head and Neck Squamous Cell Carcinoma
Archives of Iranian medicine, 2017
Squamous cell carcinoma is the most common histological subtype of head and neck cancers. In a retrospective longitudinal study, we assessed the risk of local or metastatic recurrence and death in 140 patients with head and neck squamous cell carcinoma (HNSCC). Multivariate and shared frailty models were used for survival analysis with sex, primary tumor site, grade and stage of the tumor, and treatment modalities as contributing factors. The most frequent site for HNSCC was the oral cavity (30%), followed by the tongue (26.4%). For most primary sites, men were at nearly 2-fold higher risk of local recurrence than women, but there was no difference by sex in the risk of metastatic recurrence. Undifferentiated HNSCC was associated with a higher risk of local recurrence (nearly 4-fold) and metastasis (6-15-fold based on the primary site) than well-differentiated tumors. In early months after surgical resection alone, the risk of local recurrence was higher compared to other treatment ...
Prognostic factors of unknown primary head and neck squamous cell carcinoma
Otolaryngology - Head and Neck Surgery, 2008
To evaluate the prognostic factors of unknown primary head and neck squamous cell carcinoma (HNSCC). Retrospective study. Patients with unknown primary HNSCC from 1980 to 2000 were included. Forty-eight patients, predominantly male and with a mean age of 63.3+/-11.6 years, were recruited. The median survival time (MST) was 44 months. The overall survival rate was 60.4 percent at three years and 39.6 percent at five years. Forty-two patients receiving intervention regimens had a MST of 45 months, while six patients receiving palliative therapy had a MST of 8.5 months (log rank test, P=0.016). With multivariate Cox regression analysis, age (per year), higher nodal stage (N3 vs N1 or N2), and treatment (operation vs nonoperation) had a hazard ratio of 1.081 (P&amp;amp;amp;amp;amp;amp;amp;lt;0.0001), 5.852 (P=0.010), and 0.4 (P=0.042), respectively. Older age, higher nodal stage, and palliative treatment indicated poor prognosis. Survival time might be prolonged if surgical treatment is tolerable.
Head and neck squamous cell cancer: Biology (1
Indian Journal of Otolaryngology and Head & Neck Surgery, 2007
This review is the first section of tumor biology pertaining to head and neck squamous cell carcinoma (SCCHN). It is intended to introduce the basic concepts of cancer biology to enhance the translational research. The basic tumour biology relates to the aberrations in the normal cell cycle. cell growth and cell death. The genetic aspects of cancer focus upon the roles of oncogenes, tumor suppressor genes and stability genes. The epigenetic mechanisms of the cancer relates to DNA methylation and histone acetylation. This review, discusses the basics of these concepts.
Oral Oncology, 2018
Introduction: Disruption of E-cadherin function and increased expression of vimentin and the transcriptional oncogene, SOX2, are thought to characterize epithelial to mesenchymal transition (EMT) in HNSCC that contributes to invasive and metastatic behavior. To determine if such changes relate to prognosis or host immune response, expression of these markers and correlations with clinical characteristics, histologic worst pattern of invasion (WPOI) and tumor infiltrating lymphocytes (TIL) and survival were assessed. Methods: Immunohistologic expression of markers was determined in tissue microarrays from 274 previously untreated HNSCC patients. Expression was correlated with levels of TILs in microcores and WPOI in biopsy specimens. Correlations were assessed by Kruskal-Wallis testing and Spearman correlation coefficients where appropriate. Overall and relapse-free survival were analyzed with Cox proportional hazards models. Median follow up was 60.0 months.