An Extensive Insight On Physico-Chemical Characterization Of Hot-Melt Coating Excipients (original) (raw)

2013

Abstract

Hot-melt coatings (HMC) are widely used to provide drug protection, to increase aesthetic value of products, to reduce acidity if vitamins, to provide lubrication and modified drug release. In hot-melt coating the substrates are coated with molten form of coating materials. Substrates used for coating are beads, capsules, granules, pellets, pills, spherules and tablets. Hot-melt coating devoid of solvent use, solvent disposal, solvent evaporation and solvent treatment is not required; as a result powders with very high specific surface areas can be coated rapidly. HMC technique not only protects the operators from solvent but also protect the environment. Hot-melt coating materials are mostly hydrophilic as well as hydrophobic in nature. Majority of hot-melt coating materials are obtained from natural, semi-synthetic and synthetic sources. Generally, lipids are the smart option to polymer coatings as they need melting before application directly on the substrate and make the techniq...

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