Anti-dopaminergic medication related myopathy causing respiratory muscle weakness without neuroleptic malignant syndrome (P3.461) (original) (raw)

2018

Abstract

Objective: We report a case of toxic myopathy with severe respiratory muscle weakness due to anti-dopaminergic medications. Background: Several studies report muscle toxicity related to anti-dopaminergic medications, with up to 10% of patients developing serum creatine kinase (CK) elevation. While CK elevation can be extreme in neuroleptic malignant syndrome, severe motor weakness has rarely been reported. Design/Methods: Case report Results: A 29-year-old man with history of obsessive compulsive disorder and Tourette’s syndrome presented to the hospital for worsening dyspnea. A year prior, after an increased risperidone dose from 0.5mg to 1mg daily, the patient developed severe proximal muscle weakness, including respiratory weakness, with an elevated CK of 5932 units/L. Electromyography revealed a myopathic process. Muscle biopsy showed many degenerating, vacuolated fibers with a histiocytic infiltrate and a few T-cells. After discontinuation of risperidone, the patient improved c...

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