Urachal adenocarcinoma - case report and literature review (original) (raw)
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Urachal Tumor: Mucinous Cystadenoma of Undetermined Malignant Potential
Urachal malignancy is a rare and represents less than one percent of bladder neoplasms. Urachal mucinous neoplasms are still rare and include both villous adenomas and invasive adenoma carcinomas and they have insidious course and variable clinical presentation. We present a case report of 58 year old male who presented with lower abdominal mass since 6-8 months with no lower urinary tract symptoms, significant history of loss of weight and appetite. On examination the infra-umbilical midline mobile mass of 10×10 cms was palpable. CT showed lobulated cystic mass with internal septations and calcifications superior to bladder with indentation and without any local or distant metastasis. Mass was excised in toto with partial/ segmental cystectomy. Histology revealed mucinous cystadenoma of undetermined malignant potential, rarest histological variety and difficult to diagnose on basis of mucin histochemistry and immunohistology. Two-year follow-up did not show any local tumor recurrence.
Urachal carcinoma presenting with chronic mucusuria: a case report
Cases Journal, 2008
Urachal adenocarcinoma is a rare tumor and represents 0.17-0.34% of all bladder tumors. It has an insidious course and variable clinical presentation. We present a case report of a 58 year old white male with an urachal cyst who suffered irritative voiding symptoms and long term mucusuria, since childhood. After surgical removal of the cyst with a partial cystectomy a mucus adenocarcinoma was diagnosed histologically.
Case Reports in Clinical Pathology, 2018
The urachus is an embryological remnant that extends from the bladder to the umbilicus. Urachal neoplasms represent less than 1% of malignant bladder tumors. The new 2016 edition of disease classifications from the WHO has updated the classification of epithelial neoplasms of urachal origin, distinguishing between glandular and non-glandular neoplasms and between cystic and non-cystic adenocarcinomas. In this article, we present two cases with similar clinical presentations but differing histology. We address their morphological, immunohistochemical, and molecular characterization; review the classification and diagnostic criteria of glandular urachal neoplasms included in the most recent literature with the aim of clarifying their differential diagnosis as well as their prognostic implication; and, ultimately, better understand these infrequent biological entities.
Urachal carcinoma: imaging findings
2012
Urachal carcinoma is a rare neoplasm, which accounts for only 0.5-2% of bladder malignancies, and arises from a remnant of the fetal genitourinary tract. A 46-year-old woman presented with a history of pelvic pain and frequent daytime urination. Ultrasound (US), computed tomography (CT), and magnetic resonance (MR) demonstrated a supravesical heterogeneous mass with calcifications. The patient underwent a partial cystectomy with en-bloc resection of the mass and histopathological examination revealed the diagnosis of urachal adenocarcinoma. Urachal carcinomas are usually associated with poor prognosis and early diagnosis is fundamental. CT and MR are useful to correctly diagnose and preoperatively staging.
Urachal carcinoma: Report of two cases and review of the literature
Molecular and clinical oncology, 2017
Urachal carcinoma is a rare tumor that most commonly occurs in ovaries and less often in the adnexal region and urinary system. We herein present two cases of urachal carcinoma: One case was a 32-year-old male patient who presented with painless hematuria with blood clots for 1 month, whereas the other case was a 50-year-old woman who presented with gross hematuria with mild dysuria, urgency and frequent urination for 1 year. Following surgical resection, the two patients were diagnosed with urachal adenocarcinoma (mixed type) and urachal mucinous adenocarcinoma, respectively, based on the histopathological examination. A review of previously published cases and relevant literature is also presented. The aim of the present study was to help understand this disease better, in order to reduce the rate of clinical and pathological misdiagnosis.
A Rare Case of a Urachal Mucinous Cystic Tumour of Low Malignant Potential
Cancer Studies and Molecular Medicine - Open Journal, 2018
A persistently patent urachal remnant can lead to neoplastic transformation. Urachal tumours occur most commonly as glandular neoplasms which are classified as benign, non-cystic or cystic. However, the literature on cystic urachal tumours is extremely limited. Here, we describe a case of a 59-year-old male who presented with a mucinous cystic tumour of low malignant potential of the urachus and review the current literature. In addition, we summarise the classification system on cystic urachal tumours which has been proposed by Amin et al and modified in the World Health Organisation (WHO) 2016 Classification of Tumours of the Urinary System and Male Genital Organs.
Fine Needle Aspiration Cytology Diagnosis of an Urachal Adenocarcinoma
Journal of clinical and diagnostic research : JCDR, 2016
Urachal Carcinoma (UC) is a rare malignancy of urinary bladder. It is usually found in adults in advanced stages because the tumour often grows outside the bladder without producing clinical symptoms. Most of the cases are mucinous, intestinal or signet ring cell adenocarcinoma and the diagnosis is usually made on biopsy. Radiographic images of this tumour may show characteristic features with a midline solid or cystic mass in the anterior wall of bladder associated with small calcification, which is considered as a pathognomonic sign for the diagnosis of UC. We report a case of UC in an adult, whose radiographic images suggested an urachal tumour and Fine Needle Aspiration (FNA) cytology revealed an adenocarcinoma. Laparoscopic partial cystectomy with umbilectomy and pelvic node dissection was done without further histopathological confirmation. Surgical intervention of UC on the basis of FNA diagnosis has not been reported in the literature.
Urachal Carcinoma, An Unusual Possibility of Hematuria; Case Report and Literature Review
Diagnostics
Urachal cancer is very rare, accounting for only 0.5–2% of bladder-associated malignancies and 0.01% of all cancers in adults. It has an insidious appearance, an aggressive behavior and a poor prognosis. The most common symptoms are hematuria and the presence of a palpable hypogastric mass. The scarcity of cases and the low number of studies carried out explains the lack of an evidence-based management strategy, but it seems that surgical treatment (open, laparoscopy or robot-assisted) represents the gold standard, while neoadjuvant and adjuvant chemotherapy or radiotherapy has a limited impact on overall survival. Since mucinous cystadenocarcinoma of urachal origin is a very uncommon pathological condition the differential diagnosis may be difficult and pathological investigations have to elucidate this disorder. It is worth mentioning the psychological impact on the patient in addition to the medical aspects. A rare condition is associated with heightened risk for mental health an...
A Case Report of Primary Mucinous Adenocarcinoma of Urinary Bladder with Review of Literature
American Journal of Clinical Medicine Research, 2014
The primary mucinous adenocarcinoma of the bladder is an extremely rare urologic entity, which is less than 2% of all urinary bladder tumours and often presents in advanced stage. A 68-year old gentleman was diagnosed with a primary mucinous adenocarcinoma of the bladder from biopsy of anterior abdominal wall ulcer. Immunohistochemistry was done to rule out metastasis from colon and prostate and it confirmed the nature of the tumour. As the patient presented in advanced (stage IV), palliative intent chemotherapy with gemcitabine and cisplatin was administered, however he succumbed to the illness after one cycle of chemotherapy. The primary adenocarcinoma of urinary bladder creates a diagnostic dilemma, as it is difficult to differentiate metastatic adenocarcinoma of the colon and prostate. The immunohistochemistry has a leading role, aiding in diagnosis.