Down regulation of Plasma Apolipoprotein A-IV in Suicidal Attempters: A Mass Spectrometry Based Approach (original) (raw)

Abstract

Introduction and Objective: Suicide is a major cause of mortality and a significant health problem globally. Discovery of a biological marker could help in diagnosing subjects at high risk of attempting suicide and understanding the molecular event associated with suicidal behaviour that might help in early intervention. Methods: In the present study differential expression of plasma proteins in suicidal attempters were analysed using two dimensional gel electrophoresis and protein identification was done using MALDI mass spectrometry. Results and Discussion: The differential expression analysis based on spot intensities in 2D gel showed Apolipoprotein-AIV, Retinol Binding Protein-4 and Complement C 4A protein in plasma were significantly down regulated in suicidal attempters compared to age and gender matched healthy controls. The clinical characterisation of suicidal attempters showed that all attempts were impulsive and in response to life stressors. Apo A-IV has multiple functio...

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