Skeletal muscle relaxant activity of methanolic extract of Parthenium hysterophorus L. leaves in swiss albino mice (original) (raw)

The objective of the present study was to evaluate the skeletal muscle relaxant activity of methanolic extract of the leaves of Parthenium hysterophorus L (MEPH) using Rota-Rod method and traction test . ME PH was administered orally at dose of 3mg/kg and 6 mg/kg p.o to Swiss A lbino mice. The methanolic extract significantly re duces the fall off time (motor coordination), and highly significa nt (**P<0.01) at 30 min of duration. It also shows significant muscle relaxant effect in traction test. Thus, the result suggested that the MEPH possess skeletal mu scle relaxantactivity may be due to presence of differen t chemical compounds present in the extract. Key-Words: Parthenium hysterophorus , methanolic extract, Skeletal muscle relaxant acti vity Introduction Parthenium hysterophorus L., belongs to the dicot family of flowering plants (Asteraceae) to which otherwise ornamentals like dahlia and chrysanthemum and oilseed crop plants like sunflower and safflowe r belong. It was acc...