The role of L-carnitine in neurodegenerative disorders (original) (raw)

Population ageing and modern lifestyle seem to be two important factors contributing to neurodegenerative diseases, while the underlying cellular pathophysiological mechanisms implicate the phenomenon of oxidative stress in most studies. Antioxidants such as carnitine, which neutralize directly or indirectly the action of free radicals, are suggested as pharmacological compounds which could limit these degenerative processes. In this review, we present the laboratory and clinical data on the protective effect of L-carnitine administration in neurodegenerative diseases, such as Alzheimer disease, Parkinson disease and multiple sclerosis. In addition, the potential role of carnitine in limiting degenerative events accompanying ageing, such as the decline in hearing or vision, or in limiting geriatric psychiatric diseases, is also examined.