The Frequency of Non-Epileptic Seizures in Epileptic Patients, the Relationship with Anxiety and Depression (original) (raw)
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Anxiety and Depression Frequency in Epileptic Patients
Bulletin of Clinical Psychopharmacology, 2013
Frequency of anxiety and depression in epileptic patients Objectives: Depression and anxiety are commonly seen among epileptic patients. These comorbidities have a negative effect on achievement of effective treatment and improvement in the quality of life of epileptic patients. We aimed to determine the frequency of anxiety and depression in epilepsy and in subgroups of epileptic patients and their correlation with disease duration and seizure frequency. Methods: Forty-one young male patients (13 temporal lobe epilepsy and 28 extra-temporal lobe epilepsy) and 48 young males as a healthy control group were included in the study. Each study participants completed the Beck Depression Inventory and the Beck Anxiety Inventory. Results: There were high frequencies of anxiety (26.8%) and depression (34.14%) in the epileptic patients compared with control group (p=0.003, p=0.001, respectively). Although there was no statistical significance, the temporal lobe epilepsy group had higher anxiety and depression frequencies than the extra-temporal lobe epilepsy group (p=0.280, p=0.089, respectively). There was no significant correlations between disease duration and either anxiety inventory scores or depression inventory scores. However in the temporal lobe epilepsy group, we found a correlation with a medium level of significance between seizure frequency and Beck Anxiety Inventory scores as well as Beck Depression Inventory scores (r= 0.521, p= 0.068; r= 0.615, p= 0.025). Conclusion: There were high frequencies of anxiety and depression in epileptic patients. A multidisciplinary approach and inter-disciplinary help cooperation is needed in the treatment of epilepsy. There is a need for controlled studies with larger sample sizes.
Peri-Ictal Changes in Depression and Anxiety in Persons With Epileptic and Non-epileptic Seizures
Frontiers in Psychiatry
ObjectiveWe tested the hypothesis that epileptic, but not non-epileptic, seizures would produce an improvement in comorbid depression and anxiety symptoms in the peri-ictal period, much like the antidepressant effects of electroconvulsive therapy.MethodsWe examined depression and anxiety symptoms in patients admitted to an inpatient unit for continuous video electroencephalography as part of routine clinical care. Patients completed three questionnaires that included the Beck Depression Inventory-II (BDI), Montgomery Asberg Depression Rating Scale (MADRS), and Beck Anxiety Inventory (BAI) after admission, in the 24 h following a seizure, then again 2 weeks after the last seizure.ResultsIn patients with epilepsy, depression and anxiety scores improved in the 24 hrs following a seizure (change in BDI = 24%; change in MADRS = 19%; change in BAI = 21%) but returned toward baseline after 2 weeks. In patients with non-epileptic seizures, depression and anxiety scores also improved in the ...
Depression and anxiety in epilepsy: the association with demographic and seizure-related variables
Annals of General Psychiatry, 2007
Background: Depression and anxiety are common psychiatric symptoms in patients with epilepsy, exerting a profound negative effect on health-related quality of life. Several issues, however, pertaining to their association with psychosocial, seizure-related and medication factors, remain controversial. Accordingly, the present study was designed to investigate the association of interictal mood disorders with various demographic and seizure-related variables in patients with newly-diagnosed and chronic epilepsy.
Depression and Anxiety in Patients with Epilepsy
Epilepsia, 2001
The aim of this investigation was to study the interaction between depression/anxiety and epilepsy. One hundred fifty individuals with partial epilepsy, 70 with idiopathic generalized epilepsy, and 100 controls were administered two self-rating mood questionnaires (Zung and Stai) for the evaluation of depression and anxiety, respectively. The group with epilepsy was much more severely impaired than the controls according to both mood questionnaires; the patients with partial epilepsy, especially those with temporal lobe epilepsy (TLE), were more depressed and anxious than the patients with generalized epilepsy. The group with left TLE appeared to have the highest levels of depression and anxiety. The final results of our study confirmed that some mood disorders are common throughout the epilepsy population, especially in patients with left TLE. No correlation was noted between the frequency of seizures and onset of epilepsy and the results of the mood questionnaires. Moreover, no differences were found in depression and anxiety between males and females among both left focus and right focus epilepsy patients.
Seizure, 2017
Depressive and anxiety disorders are frequent among people with epilepsies. There are, however, only few longitudinal studies, which examine the relationship between these comorbid psychiatric disorders and epilepsy-related variables. Thus, we investigated the interrelationships of depression and anxiety symptoms with seizure frequency across time. Before admittance to an epilepsy center (T1) and six months after discharge (T2), patients (n=198) with mainly difficult-to-treat epilepsies completed the Hospital Anxiety and Depression Scale (HADS). Correlation and path analyses were conducted. Depression and anxiety symptoms (HADS) as well as seizure frequency significantly decreased from baseline to follow-up. Both at T1 and T2, seizure frequency was slightly, but significantly correlated with depression and anxiety levels (rs=0.17-.32). Cross-lagged-analyses showed that baseline (T1) level of depression significantly predicted frequency of seizures at follow-up (T2). However, anxiety...
Psychiatria Danubina, 2011
Anxiety may occur as ictal, postictal or interictal symptom in patients with epilepsy. The main aim of this research was to explore the intensity and frequency of anxiety in patients with generalized, temporal and extratemporal epilepsy. This is a cross-sectional study of three groups of patients with epilepsy (30 patients per group) - recently diagnosed with generalized epilepsy, temporal epilepsy and extratemporal epilepsy, and a healthy control group (N=30). The Beck Anxiety Inventory (BAI) was used for quantitative assessment of anxiety. Patients with temporal and extratemporal epilepsies had a significantly higher mean total scores on the BAI than the patients with generalized forms of epilepsies (ANOVA: F=6.323, p<0.01). There were no statistically significant differences between the temporal and extratemporal epilepsy groups according to the levels of anxiety on BAI (t-test: t=1.68, p>0.05). For the first three symptoms - numbness, wobbling in the legs and the fear of t...
Anxiety in patients with epilepsy: Systematic review and suggestions for clinical management
Epilepsy & Behavior, 2005
Up to 50 or 60% of patients with chronic epilepsy have various mood disorders including depression and anxiety. Whereas the relationship between epilepsy and depression has received much attention, less is known about anxiety disorders. It is now recognized that anxiety can have a profound influence on the quality of life of patients with epilepsy. The relationship between anxiety disorders and epilepsy is complex. It is necessary to distinguish between different manifestations of anxiety disorder: ictal, postictal, and interictal anxiety. Preexisting vulnerability factors, neurobiological factors, iatrogenic influences (antiepileptic drugs, epilepsy surgery), and psychosocial factors are all likely to play a role, but with considerable individual differences. Despite the high prevalence of anxiety disorders in patients with epilepsy, there are no systematic treatment studies or evidence-based guidelines for best treatment practice. Nevertheless, a practical approach based on the temporal relationship between anxiety and epileptic seizures allows clinicians to consider appropriate treatment strategies to reduce the psychiatric comorbidity in patients with epilepsy.
2018
Objective: To Study the Clinical, Psychological and Neurological Profile and Assessing the Outcome Predictors of Patients with Psychogenic Non Epileptic Seizures in North Indian adult population. Design of study: A prospective observational study, conducted at tertiary teaching institute at Jaipur. Materials and Methods: Seventy-four patients with PNES were enrolled. The diagnosis was based on mobile recordings of episodes, and video-electroencephalography (video-EEG) monitoring. A detailed clinical evaluation was done including evaluation for coexistent anxiety, depression or other psychiatric disorder. Patients were followed-up to 2 months. Statistical Analysis: Appropriate statistical tests were used. Results: The mean age at onset was 22 years; with female to male ratio were 17.5:1.Coexisting epilepsy was present in 6 (8.10%).40 patients(54.05%) had received one or multiple antiepileptic drugs. Out of 74 patients of PNES 48(64.86%) had predominant motor phenomenon, whereas 26 pa...